Corynebacterium urealyticum

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Corynebacterium urealyticum is a Gram-positive, non-spore-forming, aerobic, non-motile, rod-shaped bacterium. It has been detected in at least 2 gut microbiome compilation studies or metastudies. The DNA G+C content is 61-62%. Corynebacterium urealyticum is probably a rare gut coloniser. (Pitcher1992; Bernard2012Bergey)



  • This organism has been recovered from urine and clinical sources. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: human and animal pathogen). It is an opportunistic pathogen. A possible gut commensal.
    • QUIRKS
  • Lipophilic.
    • GENERAL CHARACTERISTICS (Pitcher1992); (Bernard2012Bergey);
    Character Response
  • Substrates hydrolysed or digested:
  • urea;
  • ±
  • Strain-dependent hydrolysis or digestion:
  • hippurate;
  • 🌡
  • Temperature tolerance:
  • grows at 25℃; grows at 42℃;
  • Active enzymes:
  • catalase; urease;
    • SPECIAL FEATURES (Pitcher1992);
    Character Response
  • ✗
  • Metabolites not produced:
  • propionate;
  • ±
  • VP test:
  • strain dependent
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Tyrrell2012); (Goldstein2008); (Goldstein2006a); (Goldstein2006b);
    Class Active Resistant
  • Penicillins:
  • ampicillin;
  • amoxicillin-clavulanic acid; ampicillin-sulbactam; penicillin; piperacillin-tazobactam;
  • Cephalosporins:
  • cefotetan; ceftazidime;
  • Quinolines:
  • levofloxacin;
  • Vancomycins:
  • vancomycin; dalbavancin;
  • Miscellaneous antibiotics:
  • daptomycin; linezolid;
  • clindamycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Corynebacteriales Family:  Corynebacteriaceae Genus:  Corynebacterium Gram stain:  + O2 Relation.:  aerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  urine and clinical sources
    DNA G+C(%):  61-62
    Lower T(℃):  25(+)
    High T(℃):  42(+)
    		Aesculin:  neg Urea:  + Gelatin:  neg DNA:  neg Hippurate:  d Tween:  80(+)
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    L-Arabinose:  neg Glucose:  neg Ribose:  neg Xylose:  neg Lactose:  neg Maltose:  neg Sucrose:  neg Trehalose:  neg Glycogen:  neg Inulin:  neg Starch:  neg Mannitol:  neg Sorbitol:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  + Urease:  + DNAse:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  R(MIC50): >8, MIC90: >8, RNG: (0.06–>8)
    ampicillin:  S(MIC50): 1, MIC90: >32, RNG: (0.03–32)
    amp-sulb:  R(MIC50): >64, MIC90: >64, RNG: (1–>64)
    penicillin:  R(MIC50): >8, MIC90: >8, RNG: (0.06–>8)
    piper-taz:  R(MIC50): >32, MIC90: >32, RNG: (0.125–>32)
    doripenem:  Var(MIC50): 1, MIC90: 8, RNG: (0.25–>32)
    ertapenem:  Var(MIC50): 1, MIC90: 32, RNG: (0.5–>32)
    imipenem:  Var(MIC50): 0.25, MIC90: >8, RNG: (0.06–>8)
    meropenem:  Var(MIC50): 0.25, MIC90: >8, RNG: (0.06–>8)
    cefepime:  Var(MIC50): 1, MIC90: >32, RNG: (0.06–>32)
    cefotaxime:  Var(MIC50): 1, MIC90: >32, RNG: (0.03->32)
    cefotetan:  R(MIC50): >32, MIC90: >32, RNG: (2–>32)
    cefoxitin:  Var(MIC50): 8, MIC90: 64, RNG: (0.125–>128)
    ceftazidime:  R(MIC50): 32, MIC90: >64, RNG: (0.5–>64)
    azithromycin:  Var(MIC50): ≤0.015->128), MIC90: Var(≤0.015->128
    clarithromycin:  Var(MIC50): ≤0.015->64), MIC90: Var(≤0.015->64
    roxithromycin:  Var(MIC50): ≤0.015-128), MIC90: Var(≤0.015-128
    linezolid:  S(MIC50): 0.5, MIC90: 1, RNG: (0.125–1)
    levofloxacin:  R(MIC50): 8, MIC90: >8, RNG: (0.125–>8)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  Var(MIC50): 0.25-32), MIC90: Var(0.25-32
    dalbavancin:  S(MIC50): 0.25, MIC90: 1, RNG: (0.03–1)
    vancomycin:  S(MIC50): 0.25, MIC90: 0.5, RNG: (0.25–0.5)
    clindamycin:  R(MIC50): >8, MIC90: >8, RNG: (2–>8)
    daptomycin:  S(MIC50): 0.125, MIC90: 0.5, RNG: (0.06–0.5)

    References

    SPECIFIC REFERENCES FOR CORYNEBACTERIUM UREALYTICUM
  • Nouioui2018 - Genome-Based Taxonomic Classification of the Phylum Actinobacteria.
  • Pitcher1992 - Classification of coryneform bacteria associated with human urinary tract infection (group D2) as Corynebacterium urealyticum sp. nov.
  • Bernard2012Bergey - Bergey's manual of systematic bacteriology. Vol. 5, The Actinobacteria. Part A & B. Corynebacteriaceae, Genus I. Corynebacterium
  • Tyrrell2012 - In vitro activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic, against 377 strains of anaerobic bacteria and 34 strains of Corynebacterium species.
  • Goldstein2008 - In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds.
  • Goldstein2006a - In vitro activity of ceftobiprole against aerobic and anaerobic strains isolated from diabetic foot infections.
  • Goldstein2006b - In vitro activities of dalbavancin and 12 other agents against 329 aerobic and anaerobic gram-positive isolates recovered from diabetic foot infections.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CORYNEBACTERIUM UREALYTICUM
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
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    • Added: January 14, 2022