Cutibacterium acnes subsp. defendens

(aka Propionibacterium acnes subsp. defendens)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Cutibacterium acnes subsp. defendens, (aka Propionibacterium acnes subsp. defendens), is a Gram-positive, non-spore-forming, anaerobic, non-motile, pleiomorph rod-shaped bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 60%. Cutibacterium acnes subsp. defendens is probably a rare gut coloniser. (Scholz2016; McDowell2016)



  • This organism has been recovered from healthy skin, oral cavity and genitourinary tract. Can cause opportunistic infections, particularly in immunocompromised people. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Scholz2016); (McDowell2016);
    Character Response
  • Substrates hydrolysed or digested:
  • gelatin;
  • 🌡
  • Temperature tolerance:
  • Grows optimally at 30-37℃.
  • H+
  • Acid from carbohydrates usually produced:
  • ribose; glycerol;
  • ⥅
  • Substrates assimilated or utilised:
  • pyruvate;
  • Active enzymes:
  • catalase;
  • ±
  • Strain-dependent active enzymes:
  • lipase; pyrrolidine arylamidase;
    • SPECIAL FEATURES (McDowell2016);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; propionate; indole (most strains);
  • ✗
  • Haemolysis:
  • absent
  • ✓
  • Nitrate:
  • reduced

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Propionibacteriales Family:  Propionibacteriaceae Genus:  Cutibacterium Alt. name:  Propionibacterium acnes subsp. defendens Gram stain:  + O2 Relation.:  anaerobic Spore:  No spore Motility:  Sessile Morphology:  Pleiomorph rod
    Health:  Unknown
    Source:  healthy skin, oral cavity and genitourinary tract
    DNA G+C(%):  60
    Opt. T:  30-37℃
    		Aesculin:  neg Gelatin:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    L-Arabinose:  neg Ribose:  d(+) Maltose:  neg Sucrose:  neg Glycerol:  d(+) Sorbitol:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Pyruvate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  + PyrrolidAA:  d(neg) Lipase:  d(neg)
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Propionate:  + Indole:  d(+)

    References

    SPECIFIC REFERENCES FOR CUTIBACTERIUM ACNES SUBSP. DEFENDENS
  • Scholz2016 - The natural history of cutaneous propionibacteria, and reclassification of selected species within the genus Propionibacterium to the proposed novel genera Acidipropionibacterium gen. nov., Cutibacterium gen. nov. and Pseudopropionibacterium gen. nov.
  • McDowell2016 - Emendation of Propionibacterium acnes subsp. acnes (Deiko et al. 2015) and proposal of Propionibacterium acnes type II as Propionibacterium acnes subsp. defendens subsp. nov.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CUTIBACTERIUM ACNES SUBSP. DEFENDENS
  • King2019 - Baseline human gut microbiota profile in healthy people and standard reporting template.
  • ...............................
    • Added: February 09, 2022