Dialister invisus

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Dialister invisus is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, coccobacillus bacterium. It has been detected in at least 19 gut microbiome compilation studies or metastudies. The DNA G+C content is 45.5%. Dialister invisus is a common gut coloniser. (Downes2003; JumasBilak2005; Wade2011bBergey)



  • This organism has been recovered from human faeces, oral cavity and clinical sources (oral infections). The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. Can cause opportunistic infections, particularly in immunocompromised people. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (Downes2003); (JumasBilak2005); (Wade2011bBergey);
    Character Response
  • 💧
  • Bile tolerance:
  • Doesn't tolerate 20% bile
  • 🌡
  • Temperature tolerance:
  • grows at 30℃; grows at 42℃;
  • ⥅
  • Substrates assimilated or utilised:
  • succinate;
    • SPECIAL FEATURES (Downes2003); (JumasBilak2005); (Wade2011bBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate (minor); propionate (minor);
  • ✗
  • Metabolites not produced:
  • indole;
    • RESPONSE TO ANTIBIOTICS (Downes2003); (JumasBilak2005);
    Class Active Resistant
  • Quinolines:
  • ciprofloxacin;
  • Aminoglycosides:
  • kanamycin;
  • Heterocycles:
  • metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • colistin;
  • NOTES

    This is a common inhabitant of the oral microbiome and is also found in the gut microbiome.

    Fuel sources used:
    It can use limited types of simple sugars and protein for energy.

    Metabolites produced:
    Our genomic analysis indicates that most members of this species can produce the following metabolites: acetate, lactate, propionate, folate, biotin, riboflavin.

    Metabolites consumed:
    In addition, our genomic analysis indicates that most members of this species can consume the following metabolites: oxalate.

    Disease associations:
    In the mouth, this species is associated with periodontal infections.

    Emerging research:
    In the gut, reduced levels of this species have been observed in individuals with Crohn's disease.

  • References: [1] [2] [3]

  • Lin, A., Bik, E. M., Costello, E. K., Dethlefsen, L., Haque, R., Relman, D. A., & Singh, U. (2013). Distinct distal gut microbiome diversity and composition in healthy children from Bangladesh and the United States. PloS One, 8(1), e53838.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Negativicutes Order:  Veillonellales Family:  Veillonellaceae Genus:  Dialister Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Coccobacillus
    Health:  Unknown
    Source:  human faeces, oral cavity and clinical sources (oral infections)
    DNA G+C(%):  45.5
    Lower T(℃):  30(+)
    High T(℃):  42(+)
    Bile reaction(%):  20(neg)
    		Aesculin:  neg Urea:  neg Arginine:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg Fructose:  neg Glucose:  neg Mannose:  neg Rhamnose:  neg Ribose:  neg Xylose:  neg Cellubiose:  neg Lactose:  neg Maltose:  neg Melezitose:  neg Melibiose:  neg Trehalose:  neg Mannitol:  neg Sorbitol:  neg Salicin:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Succinate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg ArgAA:  neg GlyAA:  neg HisAA:  neg LeuAA:  neg PheAA:  neg SerAA:  neg TyrAA:  neg ValAA:  neg AcidP:  w Esterase:  w EstLip(C8):  w
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  minor(+) Propionate:  minor(+) Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    kanamycin:  R(30; disc)
    ciprofloxacin:  Sens
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    vancomycin:  R(5; disc)
    metronidazole:  S(50; disc)
    colistin:  S(10; disc)

    References

    SPECIFIC REFERENCES FOR DIALISTER INVISUS
  • Downes2003 - Dialister invisus sp. nov., isolated from the human oral cavity.
  • JumasBilak2005 - Dialister micraerophilus sp. nov. and Dialister propionicifaciens sp. nov., isolated from human clinical samples.
  • Wade2011bBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Veillonellaceae, Genus XII. Dialister
  • Bojovic2020 - Gut Microbiota Dysbiosis Associated With Altered Production of Short Chain Fatty Acids in Children With Neurodevelopmental Disorders
  • Feng2015 - Gut microbiome development along the colorectal adenoma-carcinoma sequence
  • Finegold2010 - Pyrosequencing study of fecal microflora of autistic and control children
  • Joossens2011 - Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives
  • Maffeis2016 - Association between intestinal permeability and faecal microbiota composition in Italian children with beta cell autoimmunity at risk for type 1 diabetes
  • Miragoli2017 - Impact of cystic fibrosis disease on archaea and bacteria composition of gut microbiota
  • Ventura2019 - Gut microbiome of treatment-naïve MS patients of different ethnicities early in disease course
  • Weir2013 - Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults
  • Ye2018 - A metagenomic study of the gut microbiome in Behcet's disease
  • Zhong2019 - Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naïve type 2 diabetics
  • Zhu2020 - Metagenome-wide association of gut microbiome features for schizophrenia
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR DIALISTER INVISUS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • Chung2019 - Impact of carbohydrate substrate complexity on the diversity of the human colonic microbiota.
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • Karlsson2013 - Gut metagenome in European women with normal, impaired and diabetic glucose control
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • McLaughlin2010 - The bacteriology of pouchitis: a molecular phylogenetic analysis using 16S rRNA gene cloning and sequencing.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • Nielsen2014 - MetaHIT Consortium. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Walker2011 - High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease.
  • Wang2005 - Comparison of bacterial diversity along the human intestinal tract by direct cloning and sequencing of 16S rRNA genes.
  • Wang2018 - A metagenome-wide association study of gut microbiota in asthma in UK adults
  • Wang2018a - Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model.
  • Wang2020a - Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • Zupancic2012 - Analysis of the Gut Microbiota in the Old Order Amish and Its Relation to the Metabolic Syndrome.
  • ...............................
    • GENERAL REFERENCES FOR DIALISTER INVISUS
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: February 08, 2021