Dorea longicatena

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Dorea longicatena is a Gram-positive, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 26 gut microbiome compilation studies or metastudies. The DNA G+C content is 43.8-45.6%. Dorea longicatena is often a widespread coloniser of gut. (Taras2002; Blaut2011Bergey)



  • This organism has been recovered from human faeces (CCUG). The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal. Robust growth can have mixed consequences for gut health.
    • GENERAL CHARACTERISTICS (Taras2002); (Blaut2011Bergey);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin;
  • H+
  • Acid from carbohydrates usually produced:
  • L-arabinose; fructose; galactose; glucose; xylose; amygdalin; aesculin; inulin; gentiobiose; lactose; maltose; sucrose; inositol; sorbitol; arbutin; salicin;
  • ⥅
  • Substrates assimilated or utilised:
  • amygdalin; arabinose; aesculin; glucose; inositol; maltose; sorbitol;
  • Active enzymes:
  • β-galactosidase; β-glucosidase;
  • ±
  • Strain-dependent active enzymes:
  • α-glucosidase;
    • SPECIAL FEATURES (Taras2002); (Blaut2011Bergey);
    Character Response
  • ✓
  • Metabolites produced:
  • formate; acetate; ethanol;
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
  • NOTES

    This is a common inhabitant of the human gut.

    Fuel sources used:
    It can use fibre, simple sugars (including lactose) and protein for energy.

    Metabolites produced:
    Our genomic analysis indicates that most members of this species can produce the following metabolites: acetate, BCAAs, propionate, cobalamin, folate, biotin, riboflavin.

    Metabolites consumed:
    In addition, our genomic analysis indicates that most members of this species can consume the following metabolites: oxalate.

    Disease associations:
    This species has been observed at high levels in individuals with obesity.

    Emerging research:
    This species has been observed at decreased levels in individuals with chronic fatigue syndrome, and was negatively correlated with insulin resistance in postmenopausal, obese women.

  • References: [1] [2] [3] [4] [5] [6] [7]

  • Taras, D., Simmering, R., Collins, M. D., Lawson, P. A., & Blaut, M. (2002). Reclassification of Eubacterium formicigenerans Holdeman and Moore 1974 as Dorea formicigenerans gen. nov., comb. nov., and description of Dorea longicatena sp. nov., isolated from human faeces. International Journal of Systematic and Evolutionary Microbiology, 52(Pt 2), 423–428.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Lachnospiraceae Genus:  Dorea Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Mixed
    Source:  human faeces (CCUG)
    DNA G+C(%):  43.8-45.6
    		Aesculin:  + Urea:  neg Gelatin:  neg Hippurate:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    D-Arabinose:  neg L-Arabinose:  + Fructose:  + D-Fucose:  neg Galactose:  + Glucose:  + Mannose:  neg D-Lyxose:  w Rhamnose:  neg Ribose:  neg Sorbose:  neg D-Tagatose:  neg Xylose:  + L-Xylose:  neg Cellubiose:  neg Gentiobiose:  + Lactose:  + Maltose:  + Melezitose:  neg Sucrose:  + Trehalose:  neg Turanose:  neg Amygdalin:  + Aesculin:  + Glycogen:  neg Inulin:  + Starch:  neg Adonitol:  neg D-Arabitol:  neg L-Arabitol:  w Dulcitol:  neg Erythritol:  neg Glycerol:  neg Inositol:  + Mannitol:  neg Sorbitol:  + Xylitol:  w Arbutin:  + Gluconate:  neg 2-Ketogluconate:  neg 5-Ketogluconate:  neg Me-α-D-Glc:  neg Me-α-D-Mann:  neg Me-Xyloside:  neg NAc-α-GA:  neg Salicin:  +
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Arabinose:  + Glucose:  + Mannose:  neg Rhamnose:  neg Maltose:  + Raffinose:  w Trehalose:  neg Amygdalin:  + Aesculin:  + Inositol:  + Inulin:  w Sorbitol:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  + α-Glucosidase:  d β-Glucosidase:  + β-Glucuronidase:  neg ArgDH:  neg GluDC:  neg AlanineAA:  neg GluGluAA:  neg GlyAA:  neg LeuAA:  neg LeuGlyAA:  neg PyrrolidAA:  neg AlkalineP:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Formate:  + Acetate:  + Ethanol:  + Indole:  neg

    References

    SPECIFIC REFERENCES FOR DOREA LONGICATENA
  • Taras2002 - Reclassification of Eubacterium formicigenerans Holdeman and Moore 1974 as Dorea formicigenerans gen. nov., comb. nov., and description of Dorea longicatena sp. nov., isolated from human faeces.
  • Blaut2011Bergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Lachnospiraceae, Genus VIII. Dorea
  • Petrov2017 - Analysis of Gut Microbiota in Patients with Parkinson's Disease.
  • Allin2018 - Aberrant intestinal microbiota in individuals with prediabetes
  • Borren2020 - Alterations in Fecal Microbiomes and Serum Metabolomes of Fatigued Patients With Quiescent Inflammatory Bowel Diseases
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Kamo2017 - Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure
  • Miragoli2017 - Impact of cystic fibrosis disease on archaea and bacteria composition of gut microbiota
  • MorenoArrones2019 - Analysis of the gut microbiota in alopecia areata: identification of bacterial biomarkers
  • Wang2019b - Alterations in the human gut microbiome associated with Helicobacter pylori infection
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR DOREA LONGICATENA
  • Almeida2019 - A new genomic blueprint of the human gut microbiota.
  • Browne2016 - Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • De2020 - Metagenomic analysis of gut microbiome and resistome of diarrheal fecal samples from Kolkata, India, reveals the core and variable microbiota including signatures of microbial dark matter.
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • Karlsson2013 - Gut metagenome in European women with normal, impaired and diabetic glucose control
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • LeChatelier2013 - Richness of human gut microbiome correlates with metabolic markers
  • McLaughlin2010 - The bacteriology of pouchitis: a molecular phylogenetic analysis using 16S rRNA gene cloning and sequencing.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • Nielsen2014 - MetaHIT Consortium. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.
  • Qin2012 - Metagenome-wide association study of gut microbiota in type 2 diabetes
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Rothschild2018 - Environment dominates over host genetics in shaping human gut microbiota.
  • Tyakht2013 - Human gut microbiota community structures in urban and rural populations in Russia.
  • Walker2011 - High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease.
  • Wang2018 - A metagenome-wide association study of gut microbiota in asthma in UK adults
  • Wang2018a - Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model.
  • Wang2020a - Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • ...............................
    • GENERAL REFERENCES FOR DOREA LONGICATENA
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
    • Added: February 08, 2021