Dysgonomonas capnocytophagoides

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Dysgonomonas capnocytophagoides is a Gram-negative, non-spore-forming, facultatively anaerobic, non-motile, coccobacillus bacterium. It has been detected in at least 2 gut microbiome compilation studies or metastudies. The DNA G+C content is 38%. Dysgonomonas capnocytophagoides is probably a rare gut coloniser. (Hofstad2000)



  • This organism has been recovered from clinical specimens. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. It is an opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Hofstad2000);
    Character Response
  • ±
  • Strain-dependent hydrolysis or digestion:
  • aesculin;
  • 💧
  • Bile tolerance:
  • Grows in the presence of bile
  • 🌡
  • Temperature tolerance:
  • grows at 35℃;
  • H+
  • Acid from carbohydrates usually produced:
  • glucose; mannose; xylose; lactose; maltose; melibiose; raffinose; sucrose;
  • Active enzymes:
  • Ala arylamidase; alkaline phosphatase; arabinosidase; acid phosphatase; α-galactosidase; β-galactosidase; α-glucosidase; β-glucosidase; phosphoamidase;
  • ±
  • Strain-dependent active enzymes:
  • esterase C4;
    • SPECIAL FEATURES (Hofstad2000);
    Character Response
  • ✓
  • Metabolites produced:
  • propionate; lactate; succinate; indole (strain-dependent);
  • ✗
  • Metabolites not produced:
  • H₂S;
  • ✗
  • VP test:
  • not active
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Hofstad2000);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; imipenem; meropenem;
  • benzylpenicillin;
  • Cephalosporins:
  • cefoxitin; cefpirom; ceftazidime; cefuroxime; cephalothin;
  • Macrolides:
  • azithromycin; clarithromycin; erythromycin;
  • Tetracyclines:
  • doxycycline;
  • Quinolines:
  • ciprofloxacin; ofloxacin;
  • Aminoglycosides:
  • gentamicin; netilmycin;
  • Heterocycles:
  • metronidazole; trimethoprim-sulfamethoxazole;
  • sulfadiazine;
  • Vancomycins:
  • vancomycin; teicoplanin;
  • Miscellaneous antibiotics:
  • clindamycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Bacteroidetes Class:  Bacteroidia Order:  Bacteroidales Family:  Dysgonomonadaceae Genus:  Dysgonomonas Gram stain:  neg O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Coccobacillus
    Health:  Unknown
    Source:  clinical specimens
    DNA G+C(%):  38
    Mid T(℃):  35(+)
    Bile reaction(%):  +
    		Aesculin:  d Urea:  neg Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Glucose:  + Mannose:  + Xylose:  + Lactose:  + Maltose:  + Melibiose:  + Sucrose:  + Trehalose:  neg Adonitol:  neg D-Arabitol:  neg L-Arabitol:  neg Dulcitol:  neg Inositol:  neg Mannitol:  neg Sorbitol:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg Urease:  neg α-Arab:  + Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  + β-Glucuronidase:  neg α-Mannosidase:  neg ArgDH:  neg Chymotrypsin:  neg GluDC:  neg LysDC:  neg OrnDC:  neg Trypsin:  neg AlanineAA:  + ArgAA:  neg CystineAA:  neg GlyAA:  neg HisAA:  neg LeuAA:  neg ProAA:  neg PheAA:  neg PyrogluAA:  neg SerAA:  neg TyrAA:  neg ValAA:  neg AlkalineP:  + AcidP:  + Esterase(C4):  d EstLip(C8):  neg Lipase(C14):  neg Phosphoamidase:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Propionate:  + Lactate:  + Succinate:  + H2S:  neg Indole:  (d)
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  S(1)
    ampicillin:  Var(MIC50): 6), MIC90: Var(6
    benzyl-pen:  R(>32)
    imipenem:  S(0.5)
    meropenem:  S(0.064)
    cefoxitin:  R(24)
    cefpirom:  R(256)
    ceftazidime:  R(256)
    cefuroxime:  R(256)
    cephalothin:  R(256)
    gentamicin:  R(256)
    netilmycin:  R(256)
    azithromycin:  R(16)
    erythromycin:  R(16)
    clarithromycin:  R(16)
    ciprofloxacin:  R(32)
    ofloxacin:  R(8)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(0.19)
    teicoplanin:  R(256)
    vancomycin:  R(48)
    chloramphenicol:  Var(MIC50): 4), MIC90: Var(4
    metronidazole:  S(1.5)
    sulfadiazine:  R(256)
    SXT:  S(0.125)
    clindamycin:  S(0.25)

    References

    SPECIFIC REFERENCES FOR DYSGONOMONAS CAPNOCYTOPHAGOIDES
  • Hofstad2000 - Dysgonomonas gen. nov. to accommodate Dysgonomonas gadei sp. nov., an organism isolated from a human gall bladder, and Dysgonomonas capnocytophagoides (formerly CDC group DF-3).
  • Vandamme1996b - Polyphasic analysis of strains of the genus Capnocytophaga and Centers for Disease Control group DF-3.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR DYSGONOMONAS CAPNOCYTOPHAGOIDES
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • ...............................
    • Added: February 09, 2022