Enorma massiliensis

(aka Coriobacteriaceae bacterium phI)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Enorma massiliensis, (aka Coriobacteriaceae bacterium phI), is a Gram-positive, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 7 gut microbiome compilation studies or metastudies. The DNA G+C content is 62.0%. Enorma massiliensis is probably a common, although minor, coloniser of the gut. (Mishra2013a)



  • This organism has been recovered from human faeces. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (Mishra2013a);
    Character Response
  • 🌡
  • Temperature tolerance:
  • doesn't grow at 30℃; grows at 37℃; grows at 45℃; Grows optimally at 37℃.
  • ⥅
  • Substrates assimilated or utilised:
  • mannose; raffinose;
  • Active enzymes:
  • Arg arylamidase; arginine dihydrolase; α-galactosidase; β-galactosidase; α-glucosidase; β-glucosidase; His arylamidase; Pro arylamidase;
    • SPECIAL FEATURES (Mishra2013a);
    Character Response
  • ✗
  • Metabolites not produced:
  • indole;
  • VP test:
  • activity is variable
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS
    Class Active Resistant
  • Penicillins:
  • amoxicillin; amoxicillin-clavulanic acid; imipenem;
  • penicillin;
  • Macrolides:
  • erythromycin;
  • Tetracyclines:
  • doxycycline;
  • Quinolines:
  • ciprofloxacin;
  • Aminoglycosides:
  • gentamicin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • metronidazole; nitrofurantoin;
  • trimethoprim-sulfamethoxazole;
  • Vancomycins:
  • vancomycin;

  • Lagier, J.-C., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., Trape, J.-F., Koonin, E. V., La Scola, B., & Raoult, D. (2012). Microbial culturomics: paradigm shift in the human gut microbiome study. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(12), 1185–1193.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Coriobacteriia Order:  Coriobacteriales Family:  Coriobacteriaceae Genus:  Enorma Alt. name:  Coriobacteriaceae bacterium phI Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces
    DNA G+C(%):  62.0
    Opt. T:  37℃
    Lower T(℃):  30(neg)
    Mid T(℃):  37(+)
    High T(℃):  45(+)
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Mannose:  + Raffinose:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Urease:  neg α-Arab:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  + β-Glucuronidase:  neg ArgDH:  + GluDC:  neg AlanineAA:  neg ArgAA:  + GluGluAA:  neg GlyAA:  neg HisAA:  + LeuAA:  neg LeuGlyAA:  neg ProAA:  + PheAA:  neg PyrogluAA:  neg SerAA:  neg TyrAA:  neg AlkalineP:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  Sens
    Augmentin:  Sens
    penicillin:  Res
    imipenem:  Sens
    gentamicin:  Sens
    erythromycin:  Res
    ciprofloxacin:  Res
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  Res
    vancomycin:  Sens
    rifampicin:  Sens
    metronidazole:  Sens
    nitrofurantoin:  Sens
    SXT:  Res

    References

    SPECIFIC REFERENCES FOR ENORMA MASSILIENSIS
  • Mishra2013a - Non contiguous-finished genome sequence and description of Enorma massiliensis gen. nov., sp. nov., a new member of the Family Coriobacteriaceae.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR ENORMA MASSILIENSIS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
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    • Added: April 08, 2021