Enterocloster asparagiformis

(aka Clostridium asparagiforme)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Enterocloster asparagiformis, (aka Clostridium asparagiforme), is a Gram-positive, spore-forming, strictly anaerobic, rod-shaped bacterium. It has been detected in at least 13 gut microbiome compilation studies or metastudies. The DNA G+C content is 53%. Enterocloster asparagiformis is a common gut coloniser. (Mohan2006; Rainey2011gBergey)



  • This organism has been recovered from human faeces and atherosclerotic plaques. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Is a rare opportunistic pathogen. Is a known gut commensal.
    • QUIRKS
  • In 51% of Europeans (unseenbio.com), but in 95% of subjects in study by Qin2010. Moderate coloniser.
    • GENERAL CHARACTERISTICS (Mohan2006); (Rainey2011gBergey);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin; milk;
  • ±
  • Strain-dependent hydrolysis or digestion:
  • starch;
  • 🌡
  • Temperature tolerance:
  • grows at 30℃; grows at 37℃; doesn't grow at 45℃;
  • H+
  • Acid from carbohydrates usually produced:
  • glucose;
  • Active enzymes:
  • acid phosphatase; fucosidase; α-galactosidase; β-galactosidase; α-glucosidase; β-glucosidase; naphthol-ASBI-P;
    • SPECIAL FEATURES (Mohan2006); (Rainey2011gBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • formate (minor); acetate (major); lactate (major); ethanol; H₂ (minor);
  • ✗
  • Metabolites not produced:
  • indole;
  • ±
  • Nitrate:
  • strain dependent

  • Mohan, R., Namsolleck, P., Lawson, P. A., Osterhoff, M., Collins, M. D., Alpert, C.-A., & Blaut, M. (2006). Clostridium asparagiforme sp. nov., isolated from a human faecal sample. Systematic and Applied Microbiology, 29(4), 292–299.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Clostridiaceae Genus:  Enterocloster Alt. name:  Clostridium asparagiforme Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  Endospore Morphology:  Rod
    Health:  Unknown
    Source:  human faeces and atherosclerotic plaques
    DNA G+C(%):  53
    Lower T(℃):  30(+)
    Mid T(℃):  37(+)
    High T(℃):  45(neg)
    		Aesculin:  + Starch:  d Milk:  + Meat:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Glucose:  + Mannose:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    α-Fucosidase:  + α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  + β-Glucuronidase:  neg AlkalineP:  vr AcidP:  + Esterase(C4):  vr EstLip(C8):  vr
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Formate:  minor(+) Acetate:  Major(+) Lactate:  Major(+) Ethanol:  + H2:  minor(+) Indole:  neg

    References

    SPECIFIC REFERENCES FOR ENTEROCLOSTER ASPARAGIFORMIS
  • Haas2020 - Reclassification of the Clostridium clostridioforme and Clostridium sphenoides clades as Enterocloster gen. nov. and Lacrimispora gen. nov., including reclassification of 15 taxa.
  • SelberHnatiw2020 - Metabolic networks of the human gut microbiota.
  • Feng2015 - Gut microbiome development along the colorectal adenoma-carcinoma sequence
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • DeAngelis2013 - Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified
  • Huang2019a - Metagenome-wide association study of the alterations in the intestinal microbiome composition of ankylosing spondylitis patients and the effect of traditional and herbal treatment
  • Takahashi2016 - Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease
  • Ventura2019 - Gut microbiome of treatment-naïve MS patients of different ethnicities early in disease course
  • Mohan2006 - Clostridium asparagiforme sp. nov., isolated from a human faecal sample.
  • Rainey2011gBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Clostridiaceae, Genus I. Clostridium - Cluster XIVa
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR ENTEROCLOSTER ASPARAGIFORMIS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jeong2021 - The effect of taxonomic classification by full-length 16S rRNA sequencing with a synthetic long-read technology
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • LeChatelier2013 - Richness of human gut microbiome correlates with metabolic markers
  • Qin2012 - Metagenome-wide association study of gut microbiota in type 2 diabetes
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Tyakht2013 - Human gut microbiota community structures in urban and rural populations in Russia.
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • ...............................
    • GENERAL REFERENCES FOR ENTEROCLOSTER ASPARAGIFORMIS
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
  • Alkhalil2017 - Bacterial involvements in ulcerative colitis: molecular and microbiological studies
    • Added: April 08, 2021