Facklamia hominis

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Facklamia hominis is a Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, coccus bacterium. It has been detected in at least 2 gut microbiome compilation studies or metastudies. The DNA G+C content is 41%. Facklamia hominis is probably a rare gut coloniser. (Collins1997)



  • This organism has been recovered from an abscess on the buttocks of a patient, clinical sources (blood, vagina, boil). The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. Can cause opportunistic infections, particularly in immunocompromised people. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Collins1997);
    Character Response
  • Substrates hydrolysed or digested:
  • hippurate;
  • 🧂
  • Salt tolerance:
  • tolerates 5% salt;
  • Active enzymes:
  • arginine dihydrolase; Leu arylamidase;
  • ±
  • Strain-dependent active enzymes:
  • Ala-Phe-Pro arylamidase; α-galactosidase; Gly-Trp arylamidase; pyroGlu arylamidase; pyrrolidine arylamidase; urease;
    • SPECIAL FEATURES (Collins1997);
    Character Response
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • VP test:
  • not active
  • Haemolysis:
  • alpha
  • ✗
  • Nitrate:
  • not reduced
  • ✗
  • Pigments:
  • not produced
    • RESPONSE TO ANTIBIOTICS
    Class Active Resistant
  • Penicillins:
  • amoxicillin; meropenem; penicillin;
  • Macrolides:
  • quinupristin-dalfopristin;
  • Quinolines:
  • levofloxacin; trovafloxacin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • chloramphenicol;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Bacilli Order:  Lactobacillales Family:  Aerococcaceae Genus:  Facklamia Gram stain:  + O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Coccus Pigment:  neg
    Health:  Unknown
    Source:  an abscess on the buttocks of a patient, clinical sources (blood, vagina, boil)
    DNA G+C(%):  41
    NaCl 3-5%:  5(+)
    		Aesculin:  neg Gelatin:  neg Hippurate:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    L-Arabinose:  neg Glucose:  neg Mannose:  neg Ribose:  neg D-Tagatose:  neg Xylose:  neg L-Xylose:  neg Cellubiose:  neg Lactose:  neg Maltose:  neg Sucrose:  neg Trehalose:  neg Amygdalin:  neg Glycogen:  neg Inulin:  neg D-Arabitol:  neg Mannitol:  neg Sorbitol:  neg Me-α-D-Glc:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  d α-Galactosidase:  d β-Glucosidase:  neg β-Glucuronidase:  neg β-Mannosidase:  neg ArgDH:  + Chymotrypsin:  neg Trypsin:  neg AlaPheProAA:  d GlyTrpAA:  d LeuAA:  + PyrrolidAA:  d PyrogluAA:  d ValAA:  neg AlkalineP:  neg Phosphoamidase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Indole:  neg Pigment:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  SensRNG: (0.03-0.25)
    penicillin:  SensRNG: (0.03-0.5)
    meropenem:  SensRNG: (0.06-2)
    cefotaxime:  Var(MIC50): 0.06-4), MIC90: Var(0.06-4
    cefuroxime:  Var(MIC50): 0.12-8), MIC90: Var(0.12-8
    erythromycin:  Var(MIC50): 0.06-16), MIC90: Var(0.06-16
    quin-dalf:  SensRNG: (1-4)
    levofloxacin:  SensRNG: (0.5-4)
    trovafloxacin:  SensRNG: (0.25-0.5)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    vancomycin:  SensRNG: (0.12-1)
    rifampicin:  SensRNG: (1-4)
    chloramphenicol:  SensRNG: (2-8)
    SXT:  Var(MIC50): 0.12-8), MIC90: Var(0.12-8
    clindamycin:  SensRNG: (0.06-2)

    References

    SPECIFIC REFERENCES FOR FACKLAMIA HOMINIS
  • Collins1997 - Phenotypic and phylogenetic characterization of some Globicatella-like organisms from human sources: description of Facklamia hominis gen. nov., sp. nov.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR FACKLAMIA HOMINIS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • ...............................
    • Added: January 14, 2022