Faecalitalea cylindroides

(aka Eubacterium cylindroides)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Faecalitalea cylindroides, (aka Eubacterium cylindroides), is a Gram-positive, non-spore-forming, strictly anaerobic, non-motile, bacterium. It has been detected in at least 23 gut microbiome compilation studies or metastudies. Faecalitalea cylindroides is often a widespread coloniser of gut. (Maesschalck2014; Wade2011aBergeys)



  • This organism has been recovered from human faeces. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (Maesschalck2014); (Wade2011aBergeys);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin;
  • ±
  • Strain-dependent hydrolysis or digestion:
  • starch;
  • 🌡
  • Temperature tolerance:
  • Grows optimally at 37-45℃.
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; glucose; mannose; inulin; sucrose; salicin;
  • Active enzymes:
  • acid phosphatase; esterase C4; esterase lipase C8; naphthol-ASBI-P;
  • ±
  • Strain-dependent active enzymes:
  • pyrrolidine arylamidase;
    • SPECIAL FEATURES (Maesschalck2014); (Wade2011aBergeys);
    Character Response
  • ✓
  • Metabolites produced:
  • formate; acetate; propionate; butyrate; lactate (major); ammonia;
  • ✗
  • Metabolites not produced:
  • Hâ‚‚; indole;
  • ±
  • VP test:
  • strain dependent
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Goldstein2013); (Tyrrell2012); (Citron2012a); (Wade2011aBergeys);
    Class Active Resistant
  • Penicillins:
  • ampicillin; ampicillin-sulbactam; imipenem; penicillin G; piperacillin-tazobactam;
  • Cephalosporins:
  • cefoxitin;
  • Macrolides:
  • erythromycin;
  • Quinolines:
  • moxifloxacin;
  • Heterocycles:
  • chloramphenicol; metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin; linezolid;

  • N/A

  • GutFeeling KnowledgeBase COMMENTS [Website]

    This organism has been reclassified as Faecalitalea cylindroides, instead of Eubacterium cylindroides. The members of the genus are strictly anaerobic. Cells stain Gram-positive and are pleomorphic rods that occur singly, in pairs or in short chains. Filamentous forms are often seen. They are non-motile and non-spore-forming. d-Glucose, sucrose, d-mannose and raffinose are fermented. The major end products of metabolism are lactic and butyric acids. [PMID: 25180093]

  • Cato, E. P., Salmon, C. W., & Holdeman, L. V. (1974). Eubacterium cylindroides (Rocchi) holdeman and Moore: Emended description and designation of neotype strain. International Journal of Systematic Bacteriology, 24(2), 256–259.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Erysipelotrichia Order:  Erysipelotrichales Family:  Erysipelotrichaceae Genus:  Faecalitalea Alt. name:  Eubacterium cylindroides Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile
    Health:  Unknown
    Source:  human faeces
    Opt. T:  37-45℃
    		Aesculin:  + Urea:  neg Gelatin:  neg Starch:  d Hippurate:  neg Milk:  neg Meat:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    L-Arabinose:  neg Fructose:  + Galactose:  neg Glucose:  + Mannose:  + Rhamnose:  neg Ribose:  neg Sorbose:  neg Xylose:  neg Cellubiose:  neg Lactose:  neg Maltose:  neg Melezitose:  neg Melibiose:  neg Sucrose:  d(+) Trehalose:  neg Amygdalin:  neg Aesculin:  neg Glycogen:  neg Inulin:  + Starch:  neg Adonitol:  neg Dulcitol:  neg Glycerol:  neg Mannitol:  neg Sorbitol:  neg Salicin:  d(+)
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Melibiose:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg ArgDH:  neg Chymotrypsin:  neg GluDC:  neg Trypsin:  neg AlanineAA:  neg CystineAA:  neg GluGluAA:  neg GlyAA:  neg HisAA:  neg LeuAA:  neg LeuGlyAA:  neg PyrrolidAA:  d PyrogluAA:  neg ValAA:  neg AlkalineP:  neg AcidP:  + Esterase(C4):  + EstLip(C8):  + Lipase(C14):  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Formate:  + Acetate:  + Propionate:  + Butyrate:  + Lactate:  Major(+) Ammonia:  + H2:  neg Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    ampicillin:  S(MIC50): 0.06, MIC90: 0.5, RNG: (0.06-1)
    amp-sulb:  S(MIC50): 0.125, MIC90: 1, RNG: (0.06-1)
    penicillin_G:  S(2)
    piper-taz:  S(MIC50): 0.25, MIC90: 1, RNG: (0.015–1)
    imipenem:  S(MIC50): 0.06, MIC90: 0.25, RNG: (0.015–0.5)
    cefoxitin:  S(MIC50): 4, MIC90: 16, RNG: (0.06–16)
    erythromycin:  S(3)
    fidaxomicin:  Var(MIC50): 2, MIC90: >32, RNG: (0.125–>32)
    linezolid:  S(MIC50): 1, MIC90: 4, RNG: (0.25–8)
    moxifloxacin:  S(MIC50): 0.5, MIC90: 1, RNG: (0.06–8)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  Var(MIC50): 6), MIC90: Var(6
    vancomycin:  S(MIC50): 0.5, MIC90: 1, RNG: (0.25–4)
    chloramphenicol:  S(12)
    metronidazole:  S(MIC50): 0.5, MIC90: 2, RNG: (0.125–4)
    clindamycin:  S(MIC50): 0.06, MIC90: 1, RNG: (0.06–>128)
    daptomycin:  Var(MIC50): 0.5, MIC90: 16, RNG: (0.06–32)

    References

    SPECIFIC REFERENCES FOR FAECALITALEA CYLINDROIDES
  • Maesschalck2014 - Faecalicoccus acidiformans gen. nov., sp. nov., isolated from the chicken caecum, and reclassification of Streptococcus pleomorphus (Barnes et al. 1977), Eubacterium biforme (Eggerth 1935) and Eubacterium cylindroides (Cato et al. 1974) as Faecalicoccus pleomorphus comb. nov., Holdemanella biformis gen. nov., comb. nov. and Faecalitalea cylindroides gen. nov., comb. nov., respectively, within the family Erysipelotrichaceae.
  • Schwiertz2000 - Quantification of Different Eubacterium spp. in Human Fecal Samples with Species-Specific 16S rRNA-Targeted Oligonucleotide Probes.
  • Kolho2015 - Fecal Microbiota in Pediatric Inflammatory Bowel Disease and Its Relation to Inflammation
  • Margiotta2020 - Gut microbiota composition and frailty in elderly patients with Chronic Kidney Disease
  • Moore1995 - Intestinal floras of populations that have a high risk of colon cancer
  • Goldstein2013 - In vitro activity of Biapenem plus RPX7009, a carbapenem combined with a serine β-lactamase inhibitor, against anaerobic bacteria.
  • Tyrrell2012 - In vitro activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic, against 377 strains of anaerobic bacteria and 34 strains of Corynebacterium species.
  • Citron2012a - Comparative in vitro activities of LFF571 against Clostridium difficile and 630 other intestinal strains of aerobic and anaerobic bacteria.
  • Wade2011aBergeys - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Eubacteriaceae, Genus I. Eubacterium
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR FAECALITALEA CYLINDROIDES
  • Benno1989 - Comparison of fecal microflora of elderly persons in rural and urban areas of Japan.
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Finegold1974 - Effect of diet on human fecal flora: comparison of Japanese and American diets
  • Finegold1977 - Fecal microbial flora in Seventh Day Adventist populations and control subjects.
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Holdeman1976 - Human fecal flora: variation in bacterial composition within individuals and a possible effect of emotional stress.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • Karlsson2013 - Gut metagenome in European women with normal, impaired and diabetic glucose control
  • King2019 - Baseline human gut microbiota profile in healthy people and standard reporting template.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • LeChatelier2013 - Richness of human gut microbiome correlates with metabolic markers
  • Li2019b - Disordered intestinal microbes are associated with the activity of Systemic Lupus Erythematosus
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Salonen2014 - Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men.
  • Tyakht2013 - Human gut microbiota community structures in urban and rural populations in Russia.
  • Wang2018 - A metagenome-wide association study of gut microbiota in asthma in UK adults
  • Wang2018a - Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model.
  • Woodmansey2004 - Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjects.
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • ...............................
    • GENERAL REFERENCES FOR FAECALITALEA CYLINDROIDES
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: February 08, 2021