Fannyhessea vaginae

(aka Atopobium vaginae)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Fannyhessea vaginae, (aka Atopobium vaginae), is a Gram-positive, facultatively anaerobic, non-motile, coccus bacterium. It has been detected in at least 7 gut microbiome compilation studies or metastudies. The DNA G+C content is 44%. Fannyhessea vaginae is probably a common, although minor, coloniser of the gut. (Rodriguez1999)



  • This organism has been recovered from human vagina and faeces. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. It is an opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Rodriguez1999);
    Character Response
  • Active enzymes:
  • acid phosphatase; Arg arylamidase; arginine dihydrolase; Gly arylamidase; His arylamidase; Leu arylamidase; Pro arylamidase; Ser arylamidase;
    • SPECIAL FEATURES (Rodriguez1999);
    Character Response
  • ✓
  • Metabolites produced:
  • lactate;
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Backer2010);
    Class Active Resistant

    Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Actinomycetales Family:  Actinomycetaceae Genus:  Fannyhessea Alt. name:  Atopobium vaginae Gram stain:  + O2 Relation.:  facultatively anaerobic Motility:  Sessile Morphology:  Coccus
    Health:  Unknown
    Source:  human vagina and faeces
    DNA G+C(%):  44
    		Aesculin:  neg Urea:  neg Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Mannose:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Urease:  neg α-Arab:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg ArgDH:  + Chymotrypsin:  neg GluDC:  neg Trypsin:  neg AlanineAA:  neg ArgAA:  + CystineAA:  neg GluGluAA:  neg GlyAA:  + HisAA:  + LeuAA:  + ProAA:  + PheAA:  w PyrogluAA:  neg SerAA:  + TyrAA:  neg AcidP:  + Esterase(C4):  neg EstLip(C8):  neg Lipase(C14):  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Lactate:  + Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    metronidazole:  Var(MIC50): 8, MIC90: 32, RNG: (4-64)

    References

    SPECIFIC REFERENCES FOR FANNYHESSEA VAGINAE
  • Nouioui2018 - Genome-Based Taxonomic Classification of the Phylum Actinobacteria.
  • Backer2010 - In vitro activity of secnidazole against Atopobium vaginae, an anaerobic pathogen involved in bacterial vaginosis.
  • Rodriguez1999 - Characterization of a novel Atopobium isolate from the human vagina: description of Atopobium vaginae sp. nov.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR FANNYHESSEA VAGINAE
  • Almeida2019 - A new genomic blueprint of the human gut microbiota.
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
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    • Added: December 15, 2021