Filifactor villosus

(aka Clostridium villosum)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Filifactor villosus, (aka Clostridium villosum), is a Gram-positive, rarely spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 2 gut microbiome compilation studies or metastudies. Filifactor villosus is likely to be transient and not a long-term gut coloniser. (Jalava2011Bergey; Love1979)



  • This organism has been recovered from a cat abscess and human faeces. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. It is an opportunistic pathogen. Likely to be transient and not a long-term gut commensal. Robust growth can have negative consequences for gut health.
    • GENERAL CHARACTERISTICS (Jalava2011Bergey); (Love1979);
    Character Response
  • ⥅
  • Substrates assimilated or utilised:
  • pyruvate;
    • SPECIAL FEATURES (Jalava2011Bergey); (Love1979);
    Character Response
  • ✓
  • Metabolites produced:
  • formate; acetate; butyrate (major); lactate (trace); isobutyrate; succinate (trace); isovalerate;
  • ✗
  • Metabolites not produced:
  • propionate; ammonia;
  • ✗
  • Haemolysis:
  • absent
    • RESPONSE TO ANTIBIOTICS (Jalava2011Bergey); (Love1979);
    Class Active Resistant
  • Penicillins:
  • amoxicillin; carbenicillin; penicillin;
  • Macrolides:
  • erythromycin;
  • Tetracyclines:
  • doxycycline;
  • Heterocycles:
  • chloramphenicol;
  • NOTES

    Produces the metabolites, isobutyrate, isovalerate and methylmalonate.

  • Lagier, J.-C., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., Trape, J.-F., Koonin, E. V., La Scola, B., & Raoult, D. (2012). Microbial culturomics: paradigm shift in the human gut microbiome study. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(12), 1185–1193.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Peptostreptococcaceae Genus:  Filifactor Alt. name:  Clostridium villosum Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  Rare Motility:  Sessile Morphology:  Rod
    Health:   Negative
    Source:  a cat abscess and human faeces
    		Gelatin:  w
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Fructose:  neg Glucose:  neg Mannose:  neg Ribose:  neg Xylose:  neg Lactose:  neg Maltose:  neg Melibiose:  neg Sucrose:  neg Aesculin:  neg Mannitol:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Lactate:  neg Pyruvate:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  S(2.5)
    carbenicil:  S(100)
    penicillin:  S(2U)
    erythromycin:  S(3)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(6)
    chloramphenicol:  S(12)

    References

    SPECIFIC REFERENCES FOR FILIFACTOR VILLOSUS
  • Jalava2011Bergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Peptostreptococcaceae, Genus II. Filifactor
  • Love1979 - Clostridium villosum sp. nov. from Subcutaneous Abscesses in Cats.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR FILIFACTOR VILLOSUS
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • ...............................
    • GENERAL REFERENCES FOR FILIFACTOR VILLOSUS
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: April 08, 2021