Fusicatenibacter saccharivorans

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Fusicatenibacter saccharivorans is a Gram-positive, spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 9 gut microbiome compilation studies or metastudies. The DNA G+C content is 46.9-47.2%. Fusicatenibacter saccharivorans is a common gut coloniser. (Browne2016; Takada2013)



  • This organism has been recovered from human faeces. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal.
    • QUIRKS
  • In 100% of Europeans (unseenbio.com).
    • GENERAL CHARACTERISTICS (Takada2013);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin;
  • H+
  • Acid from carbohydrates usually produced:
  • arabinose; glucose; mannose; rhamnose; xylose; inulin; cellubiose; lactose; maltose; raffinose; sucrose; trehalose; sorbitol; salicin;
  • Active enzymes:
  • alkaline phosphatase; acid phosphatase; esterase C4; esterase lipase C8; α-galactosidase; β-galactosidase; α-glucosidase; β-glucosidase; Leu arylamidase; naphthol-ASBI-P;
    • SPECIAL FEATURES (Takada2013);
    Character Response
  • ✓
  • Metabolites produced:
  • formate; acetate; lactate; succinate;
  • ✗
  • Metabolites not produced:
  • H₂S; ammonia; indole;
  • ✗
  • Haemolysis:
  • absent
  • NOTES

    This is a recently discovered species and an inhabitant of the human gut.

    Fuel sources used:
    It can use fibre, simple sugars (including lactose) and limited types of protein for energy.

    Metabolites produced:
    Our genomic analysis indicates that most members of this species can produce the following metabolites: acetate, ammonia, B-glucuronidase, BCAAs, lactate, cobalamin, folate.

    Metabolites consumed:
    In addition, our genomic analysis indicates that most members of this species do not consume any reported metabolites.

  • References: [1]

  • Takada, T., Kurakawa, T., Tsuji, H., & Nomoto, K. (2013). Characterization and classification of a novel microbe, Fusicatenibacter saccharivorans gen. Int. J. Syst. Evol. Microbiol, v.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Lachnospiraceae Genus:  Fusicatenibacter Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  Endospore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces
    DNA G+C(%):  46.9-47.2
    		Aesculin:  + Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  + Glucose:  + Mannose:  + Rhamnose:  + Xylose:  + Cellubiose:  + Lactose:  + Maltose:  + Melezitose:  w Sucrose:  + Trehalose:  + Inulin:  + Glycerol:  neg Mannitol:  neg Sorbitol:  + Salicin:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Urease:  neg α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  + β-Glucuronidase:  w Chymotrypsin:  neg Trypsin:  neg CystineAA:  neg LeuAA:  + ValAA:  neg AlkalineP:  + AcidP:  + Esterase(C4):  + EstLip(C8):  + Lipase(C14):  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Formate:  + Acetate:  + Lactate:  + Succinate:  + H2S:  neg Ammonia:  neg Indole:  neg

    References

    SPECIFIC REFERENCES FOR FUSICATENIBACTER SACCHARIVORANS
  • Browne2016 - Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.
  • Takada2013 - Fusicatenibacter saccharivorans gen. nov., sp. nov., isolated from human faeces.
  • Coretti2018 - Gut Microbiota Features in Young Children With Autism Spectrum Disorders
  • Takeshita2016 - A Single Species of Clostridium Subcluster XIVa Decreased in Ulcerative Colitis Patients
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR FUSICATENIBACTER SACCHARIVORANS
  • Browne2016 - Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chung2019 - Impact of carbohydrate substrate complexity on the diversity of the human colonic microbiota.
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • ...............................
    • GENERAL REFERENCES FOR FUSICATENIBACTER SACCHARIVORANS
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: February 08, 2021