Fusobacterium canifelinum

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Fusobacterium canifelinum is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 26-28%. Fusobacterium canifelinum is probably a rare gut coloniser. (Gharbia2010Bergey; Conrads2004)



  • This organism has been recovered from cats and dogs, and bites from them in humans. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: zoonotic pathogen). It is an opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Gharbia2010Bergey); (Conrads2004);
    Character Response
  • 💧
  • Bile tolerance:
  • Doesn't tolerate bile
  • ±
  • Strain-dependent acid from carbs:
  • glucose;
  • ⥅
  • Substrates assimilated or utilised:
  • threonine;
    • SPECIAL FEATURES (Gharbia2010Bergey); (Conrads2004);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; propionate; butyrate; indole;
  • Haemolysis:
  • beta(absent)
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Conrads2004); (Goldstein2018); (Goldstein2017);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; meropenem; penicillin; penicillin G; piperacillin-tazobactam;
  • Tetracyclines:
  • minocycline; tetracycline; tigecycline;
  • Quinolines:
  • ciprofloxacin; gatifloxacin; gemifloxacin; levofloxacin; moxifloxacin; norfloxacin;
  • Heterocycles:
  • metronidazole;
  • Miscellaneous antibiotics:
  • clindamycin; linezolid;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Fusobacteria Class:  Fusobacteriia Order:  Fusobacteriales Family:  Fusobacteriaceae Genus:  Fusobacterium Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  cats and dogs, and bites from them in humans
    DNA G+C(%):  26-28
    Bile reaction(%):  neg
    		Aesculin:  neg Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Fructose:  w Glucose:  d(w) Mannose:  neg Cellubiose:  neg Lactose:  neg Maltose:  neg Sucrose:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Thr:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Ac-β-glcamnd:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg ArgAA:  neg SerAA:  neg AlkalineP:  neg AcidP:  neg Esterase(C4):  neg EstLip(C8):  neg Lipase:  neg Phosphoamidase:  w
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Propionate:  + Butyrate:  + Indole:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  S(MIC50): 0.125, MIC90: 2, RNG: (0.125–4)
    penicillin:  S(MIC50): 0.03, MIC90: 0.03, RNG: (0.03–0.03)
    penicillin_G:  Sens
    piper-taz:  S(MIC50): 0.03, MIC90: 0.03, RNG: (0.03–0.03)
    meropenem:  S(MIC50): 0.03, MIC90: 0.03, RNG: (0.03–0.03)
    linezolid:  S(MIC50): 1, MIC90: 1, RNG: (0.5–1)
    ciprofloxacin:  R(>4)
    gatifloxacin:  R(>4)
    gemifloxacin:  R(>4)
    levofloxacin:  R(>4)
    moxifloxacin:  R(MIC50): >16, MIC90: >16, RNG: (>16–>16)
    norfloxacin:  R(>4)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    minocycline:  S(MIC50): 0.03, MIC90: 0.125, RNG: (0.03–0.125)
    tetracycline:  S(MIC50): 0.125, MIC90: 0.5, RNG: (0.06–0.5)
    tigecycline:  S(MIC50): 0.06, MIC90: 0.125, RNG: (0.03–0.125)
    metronidazole:  S(MIC50): 0.125, MIC90: 0.5, RNG: (0.06–0.5)
    clindamycin:  S(MIC50): 0.06, MIC90: 0.125, RNG: (0.03–0.125)

    References

    SPECIFIC REFERENCES FOR FUSOBACTERIUM CANIFELINUM
  • Gharbia2010Bergey - Bergey's manual of systematic bacteriology. Vol. 4, The Fusobacteria. Family Fusobacteriaceae, Genus I. Fusobacterium
  • Conrads2004 - Fusobacterium canifelinum sp. nov., from the Oral Cavity of Cats and Dogs
  • Goldstein2018 - Comparative In Vitro Activity of Omadacycline against Dog and Cat Bite Wound Isolates.
  • Goldstein2017 - In Vitro Activity of Pexiganan and 10 Comparator Antimicrobials against 234 Isolates, Including 93 Pasteurella Species and 50 Anaerobic Bacterial Isolates Recovered from Animal Bite Wounds.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR FUSOBACTERIUM CANIFELINUM
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
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    • Added: January 14, 2022