Fusobacterium nucleatum subsp. vincentii

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Fusobacterium nucleatum subsp. vincentii is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 26-28%. Fusobacterium nucleatum subsp. vincentii is probably a rare gut coloniser. (Gharbia2010aBergey; Kook2017; Dzink1990)



  • This organism has been recovered from human gut and clinical sources (blood, periodontal pocket - CCUG). The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. It is an opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Gharbia2010aBergey); (Kook2017); (Dzink1990);
    Character Response
  • 💧
  • Bile tolerance:
  • Doesn't tolerate 20% bile
  • pH
  • Acidity tolerance:
  • Grows optimally at pH 7.
  • 🌡
  • Temperature tolerance:
  • Grows optimally at 35-37℃.
  • ⥅
  • Substrates assimilated or utilised:
  • glutamate; histidine; lysine; serine; glutamine;
  • ±
  • Strain-dependent substrate utilisation:
  • glucose;
    • SPECIAL FEATURES (Gharbia2010aBergey); (Kook2017); (Dzink1990);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; butyrate; H₂S; indole;
  • ✗
  • VP test:
  • not active
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Gharbia2010aBergey);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid;
  • amoxicillin;
  • Macrolides:
  • erythromycin;
  • Quinolines:
  • clinafloxacin;
  • Aminoglycosides:
  • kanamycin;
  • Heterocycles:
  • chloramphenicol; metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • linezolid; colistin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Fusobacteria Class:  Fusobacteriia Order:  Fusobacteriales Family:  Fusobacteriaceae Genus:  Fusobacterium Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human gut and clinical sources (blood, periodontal pocket - CCUG)
    DNA G+C(%):  26-28
    Opt. T:  35-37℃
    Opt. pH:  7
    Bile reaction(%):  20(neg)
    		Aesculin:  neg Urea:  neg Gelatin:  w
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg Glucose:  w Mannose:  neg Rhamnose:  neg Ribose:  neg Sorbose:  neg Cellubiose:  neg Lactose:  neg Maltose:  neg Melezitose:  neg Glycogen:  neg Inulin:  neg Adonitol:  neg Glycerol:  neg Inositol:  neg Mannitol:  neg Sorbitol:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Fructose:  w Glucose:  d(neg) Glu:  + His:  + Lys:  + Ser:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg AlkalineP:  neg AcidP:  neg Esterase(C4):  neg EstLip(C8):  neg Lecithinase:  neg Lipase(C14):  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Butyrate:  + H2S:  + Indole:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  Res
    Augmentin:  Sens
    kanamycin:  S(1000; disc)
    erythromycin:  R(3; disc)
    linezolid:  Sens
    clinafloxacin:  Sens
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    vancomycin:  R(5; disc)
    chloramphenicol:  Sens
    metronidazole:  Sens
    colistin:  S(10; disc)

    References

    SPECIFIC REFERENCES FOR FUSOBACTERIUM NUCLEATUM SUBSP. VINCENTII
  • Gharbia2010aBergey - Bergey's manual of systematic bacteriology. Vol. 4, The Fusobacteria. Family Fusobacteriaceae, Genus I. Fusobacterium
  • Kook2017 - Genome-Based Reclassification of Fusobacterium nucleatum Subspecies at the Species Level.
  • Dzink1990 - Dzink JL, Sheenan MT, Socransky SS. Proposal of three subspecies of Fusobacterium nucleatum Knorr 1922: Fusobacterium nucleatum subsp. nucleatum subsp. nov., comb. nov.; Fusobacterium nucleatum subsp. polymorphum subsp. nov., nom. rev., comb. nov.; and Fusobacterium nucleatum subsp. vincentii subsp. nov., nom. rev., comb. nov.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR FUSOBACTERIUM NUCLEATUM SUBSP. VINCENTII
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
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    • Added: December 15, 2021