Fusobacterium periodonticum

(aka Fusobacterium sp. 2_1_31)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Fusobacterium periodonticum, (aka Fusobacterium sp. 2_1_31), is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 7 gut microbiome compilation studies or metastudies. The DNA G+C content is 28%. Fusobacterium periodonticum is probably a common, although minor, coloniser of the gut. (Slots1983; Gharbia2010aBergey)



  • This organism has been recovered from dental disease and human faeces. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. It is an opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Slots1983); (Gharbia2010aBergey);
    Character Response
  • Substrates hydrolysed or digested:
  • hippurate; milk;
  • 💧
  • Bile tolerance:
  • Doesn't tolerate bile
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; galactose; glucose;
  • ⥅
  • Substrates assimilated or utilised:
  • fructose; glucose; threonine; pyruvate;
  • Active enzymes:
  • glutamic acid decarboxylase;
    • SPECIAL FEATURES (Slots1983); (Gharbia2010aBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate (major); propionate; butyrate; lactate; succinate (minor); H₂S; indole;
  • ✗
  • Metabolites not produced:
  • isobutyrate; isovalerate;
  • ✗
  • VP test:
  • not active
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
  • ✗
  • Nitrite:
  • not reduced
  • ✗
  • NO3➔NO2:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (AlmaguerFlores2006); (Slots1983); (Gharbia2010aBergey);
    Class Active Resistant
  • Penicillins:
  • amoxicillin; penicillin G;
  • Macrolides:
  • erythromycin;
  • Tetracyclines:
  • doxycycline;
  • tetracycline;
  • Heterocycles:
  • chloramphenicol;
  • Vancomycins:
  • vancomycin;

  • Wang, M., Ahrné, S., Jeppsson, B., & Molin, G. (2005). Comparison of bacterial diversity along the human intestinal tract by direct cloning and sequencing of 16S rRNA genes. FEMS Microbiology Ecology, 54(2), 219–231.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Fusobacteria Class:  Fusobacteriia Order:  Fusobacteriales Family:  Fusobacteriaceae Genus:  Fusobacterium Alt. name:  Fusobacterium sp. 2_1_31 Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  dental disease and human faeces
    DNA G+C(%):  28
    Bile reaction(%):  neg
    		Aesculin:  neg Urea:  neg Gelatin:  neg Starch:  neg Casein:  neg Arginine:  neg DNA:  neg Tyrosine:  neg Hippurate:  + Milk:  + Tween:  80(neg)
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg Fructose:  + Galactose:  + Glucose:  + Mannose:  neg Rhamnose:  neg Ribose:  neg Xylose:  neg Cellubiose:  neg Lactose:  neg Maltose:  neg Melezitose:  neg Melibiose:  neg Sucrose:  neg Trehalose:  neg Amygdalin:  neg Aesculin:  neg Glycogen:  neg Inulin:  neg Starch:  neg Adonitol:  neg Glycerol:  neg Inositol:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Fructose:  w(+) Glucose:  w(+) Mannose:  neg Lactose:  neg Maltose:  neg Raffinose:  neg Sucrose:  neg Thr:  + Lactate:  neg Malonate:  neg Pyruvate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg ArgDH:  neg ArgDC:  neg Chymotrypsin:  neg GluDC:  + OrnDC:  neg Phe deaminase:  neg Trypsin:  neg AlanineAA:  neg CystineAA:  neg GluGluAA:  neg GlyAA:  neg LeuAA:  neg LeuGlyAA:  neg PyrrolidAA:  neg ValAA:  neg AlkalineP:  neg AcidP:  neg Esterase(C4):  neg EstLip(C8):  w Lecithinase:  neg Lipase:  neg Lipase(C14):  neg Phosphoamidase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  Major(+) Propionate:  + Butyrate:  + Lactate:  + Isobutyrate:  neg Succinate:  minor(+) Isovalerate:  neg H2S:  + Indole:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  R(32)
    penicillin_G:  R(5)
    erythromycin:  S(5)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(0.5)
    tetracycline:  R(5)
    vancomycin:  S(5)
    chloramphenicol:  R(5)

    References

    SPECIFIC REFERENCES FOR FUSOBACTERIUM PERIODONTICUM
  • AlmaguerFlores2006 - Proportion of antibiotic resistance in subgingival plaque samples from Mexican subjects.
  • Slots1983 - Fusobacterium periodonticum, A New Species from the Human Oral Cavity.
  • Gharbia2010aBergey - Bergey's manual of systematic bacteriology. Vol. 4, The Fusobacteria. Family Fusobacteriaceae, Genus I. Fusobacterium
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • Saito2019 - Metagenomic analyses of the gut microbiota associated with colorectal adenoma
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR FUSOBACTERIUM PERIODONTICUM
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
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    • Added: April 08, 2021