Fusobacterium ulcerans

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Fusobacterium ulcerans is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 13 gut microbiome compilation studies or metastudies. The DNA G+C content is 29.2-29.5%. Fusobacterium ulcerans is probably a rare gut coloniser. (Gharbia2010aBergey; Adriaans1988)



  • This organism has been recovered from tropical ulcers and human faeces. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. It is an opportunistic pathogen. A possible gut commensal.
    • QUIRKS
  • Few Europeans have it (unseenbio.com).
    • GENERAL CHARACTERISTICS (Gharbia2010aBergey); (Adriaans1988);
    Character Response
  • 🌡
  • Temperature tolerance:
  • Grows optimally at 37℃.
  • H+
  • Acid from carbohydrates usually produced:
  • glucose;
  • ±
  • Strain-dependent acid from carbs:
  • mannose;
  • Active enzymes:
  • acid phosphatase;
    • SPECIAL FEATURES (Gharbia2010aBergey); (Adriaans1988);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; propionate; butyrate (major); lactate; succinate;
  • ✗
  • Metabolites not produced:
  • H₂S; indole;
  • ✗
  • Haemolysis:
  • absent
  • ✓
  • Nitrate:
  • reduced
    • RESPONSE TO ANTIBIOTICS (Gharbia2010aBergey); (Adriaans1988); (Goldstein1999); (Goldstein1999b);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; imipenem; penicillin; penicillin G;
  • Cephalosporins:
  • cefoxitin;
  • Macrolides:
  • clarithromycin; erythromycin; roxithromycin; telithromycin;
  • Quinolines:
  • gemifloxacin; trovafloxacin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • metronidazole;
  • Miscellaneous antibiotics:
  • clindamycin;
  • telithromycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Fusobacteria Class:  Fusobacteriia Order:  Fusobacteriales Family:  Fusobacteriaceae Genus:  Fusobacterium Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  tropical ulcers and human faeces
    DNA G+C(%):  29.2-29.5
    Opt. T:  37℃
    		Aesculin:  neg Urea:  neg Gelatin:  neg Starch:  neg Meat:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg Fructose:  neg Glucose:  + Mannose:  d Rhamnose:  neg Lactose:  neg Maltose:  neg Sucrose:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg AlkalineP:  neg AcidP:  + Esterase(C4):  neg EstLip(C8):  neg Lecithinase:  neg Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Propionate:  + Butyrate:  Major(+) Lactate:  + Succinate:  + H2S:  neg Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  S(MIC50): 1, MIC90: 2, RNG: (0.125–>4)
    penicillin:  S(2U)
    penicillin_G:  S(MIC50): 0.25, MIC90: 0.5, RNG: (≤0.015–>32)
    imipenem:  S(MIC50): 0.5, MIC90: 1, RNG: (0.25–1)
    cefotaxime:  Var(MIC50): 0.5, MIC90: >32, RNG: (0.25–>32)
    cefoxitin:  S(MIC50): 4, MIC90: 8, RNG: (1–8)
    azithromycin:  Var(MIC50): 1->32), MIC90: Var(1->32
    erythromycin:  R(MIC50): >32, MIC90: >32, RNG: (8–>32)
    clarithromycin:  R(MIC50): >32, MIC90: >32, RNG: (4–>32)
    roxithromycin:  R(MIC50): >32, MIC90: >32, RNG: (8–>32)
    telithromycin:  R(MIC50): 32, MIC90: >32, RNG: (2–>32)
    gemifloxacin:  S(MIC50): 1, MIC90: 2, RNG: (0.125–8)
    levofloxacin:  Var(MIC50): 8, MIC90: >16, RNG: (1–>16)
    sparfloxacin:  Var(MIC50): 8, MIC90: >16, RNG: (1–>16)
    trovafloxacin:  S(MIC50): 4, MIC90: 4, RNG: (1–>8)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    rifampicin:  R(7.5; disc)
    metronidazole:  S(MIC50): 0.5, MIC90: 1, RNG: (0.125–1)
    clindamycin:  S(MIC50): 1, MIC90: 8, RNG: (0.06–8)

    References

    SPECIFIC REFERENCES FOR FUSOBACTERIUM ULCERANS
  • Gharbia2010aBergey - Bergey's manual of systematic bacteriology. Vol. 4, The Fusobacteria. Family Fusobacteriaceae, Genus I. Fusobacterium
  • Adriaans1988 - Fusobacterium ulcerans sp. nov. from Tropical Ulcers
  • Goldstein1999 - In vitro activity of gemifloxacin (SB 265805) against anaerobes.
  • Goldstein1999b - Activities of telithromycin (HMR 3647, RU 66647) compared to those of erythromycin, azithromycin, clarithromycin, roxithromycin, and other antimicrobial agents against unusual anaerobes.
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR FUSOBACTERIUM ULCERANS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jeong2021 - The effect of taxonomic classification by full-length 16S rRNA sequencing with a synthetic long-read technology
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • Tyakht2013 - Human gut microbiota community structures in urban and rural populations in Russia.
  • Wang2020a - Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
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    • Added: December 15, 2021