Hathewaya histolytica

(aka Clostridium histolyticum)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Hathewaya histolytica, (aka Clostridium histolyticum), is a Gram-positive, spore-forming, strictly anaerobic, motile, rod-shaped bacterium. It has been detected in at least 2 gut microbiome compilation studies or metastudies. Hathewaya histolytica is probably a rare gut coloniser. (Hall1922; Rainey2011bBergey)



  • This organism has been recovered from human intestine (Rainey2011bBergey), estuary sediment, clinical sources (wounds, gas gangrene) and soil. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. It is an opportunistic pathogen. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (Hall1922); (Rainey2011bBergey);
    Character Response
  • 🧂
  • Salt tolerance:
  • tolerates 1% salt; Grows optimally with 1.5% salt.
  • pH
  • Acidity tolerance:
  • tolerates pH 6.0; tolerates pH 9.5;
  • 🌡
  • Temperature tolerance:
  • grows at 25℃; grows at 50℃; Grows optimally at 35℃.
    • SPECIAL FEATURES
    Character Response
  • Haemolysis:
  • beta
    • RESPONSE TO ANTIBIOTICS
    Class Active Resistant
  • Penicillins:
  • amoxicillin; amoxicillin-clavulanic acid; imipenem;
  • Cephalosporins:
  • cefuroxime;
  • cefaclor;
  • Macrolides:
  • fidaxomicin; quinupristin-dalfopristin;
  • Quinolines:
  • gatifloxacin; moxifloxacin;
  • Heterocycles:
  • metronidazole;
  • Vancomycins:
  • vancomycin; teicoplanin;
  • Miscellaneous antibiotics:
  • clindamycin; ranbezolid;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Clostridiaceae Genus:  Hathewaya Alt. name:  Clostridium histolyticum Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  Endospore Motility:  Swimming Morphology:  Rod
    Health:  Unknown
    Source:  human intestine (Rainey2011bBergey), estuary sediment, clinical sources (wounds, gas gangrene) and soil
    Opt. T:  35℃
    Lower T(℃):  25(+)
    High T(℃):  50(+)
    NaCl 0.5-2%:  1(+)
    pH 6.0-8.0:  6.0(+)
    pH >8:  9.5(+)
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Arabinose:  neg Fructose:  neg Galactose:  neg Mannose:  neg Rhamnose:  neg Ribose:  neg Xylose:  neg Cellubiose:  neg Lactose:  neg Maltose:  neg Melezitose:  neg Raffinose:  neg Sucrose:  neg Trehalose:  neg Amygdalin:  neg Glycogen:  neg Inulin:  neg Mannitol:  neg Salicin:  neg Sorbitol:  neg Starch:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Lecithinase:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  S(MIC50): ≤0.125, MIC90: 0.5, RNG: (≤0.125-0.5)
    Augmentin:  S(MIC50): ≤0.125, MIC90: 0.5, RNG: (≤0.125-0.5)
    imipenem:  S(MIC50): 0.125, MIC90: 0.5, RNG: (0.06-0.5)
    cefaclor:  R(MIC50): 8, MIC90: -, RNG: (8-32)
    cefixime:  Var(MIC50): 1, MIC90: -, RNG: (1-64)
    cefpodoxime:  Var(MIC50): 8, MIC90: -, RNG: (0.25-16)
    cefprozil:  Var(MIC50): 2, MIC90: -, RNG: (1-16)
    cefuroxime:  S(MIC50): 2, MIC90: -, RNG: (0.5-4)
    fidaxomicin:  S(MIC50): ≤0.016, MIC90: 0.03, RNG: (≤0.016-0.06)
    quin-dalf:  S(MIC50): 0.5, MIC90: 1, RNG: (0.25-1)
    linezolid:  Var(MIC50): 2, MIC90: 8, RNG: (1-8)
    gatifloxacin:  S(MIC50): 0.5, MIC90: 2, RNG: (0.25-2)
    moxifloxacin:  S(MIC50): 0.5, MIC90: 2, RNG: (0.25-2)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    teicoplanin:  S(MIC50): ≤0.06, MIC90: 0.5, RNG: (≤0.06-4)
    vancomycin:  S(MIC50): 1, MIC90: 2, RNG: (0.5-2)
    metronidazole:  S(MIC50): 0.5, MIC90: 0.5, RNG: (≤0.125-1)
    ranbezolid:  S(MIC50): 0.03, MIC90: 0.06, RNG: (≤0.008-0.06)
    clindamycin:  S(MIC50): 1, MIC90: 8, RNG: (0.03-8)

    References

    SPECIFIC REFERENCES FOR HATHEWAYA HISTOLYTICA
  • Hall1922 - Differentiation and identification of the sporulating anaerobes.
  • DePalma2010 - Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
  • Parracho2005 - Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children
  • Rainey2011bBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Clostridiaceae, Genus I. Clostridium - Cluster II
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR HATHEWAYA HISTOLYTICA
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • ...............................
    • GENERAL REFERENCES FOR HATHEWAYA HISTOLYTICA
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
  • Rainey2011bBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Clostridiaceae, Genus I. Clostridium - Cluster II
    • Added: April 22, 2021