Hungatella hathewayi

(aka Clostridium hathewayi)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Hungatella hathewayi, (aka Clostridium hathewayi), is a Gram-positive, spore-forming, strictly anaerobic, motile, rod-shaped bacterium. It has been detected in at least 23 gut microbiome compilation studies or metastudies. The DNA G+C content is 50.9%. Hungatella hathewayi is often a widespread coloniser of gut. (Browne2016; Kaur2014; Steer2001; Rainey2011gBergey)



  • This organism has been recovered from human faeces, blood and atherosclerotic plaques. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Is a rare opportunistic pathogen. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (Kaur2014); (Steer2001); (Rainey2011gBergey);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin; starch;
  • 🧂
  • Salt tolerance:
  • tolerates 0.5-2.0% salt; tolerates 2.5% salt;
  • pH
  • Acidity tolerance:
  • tolerates pH 5; tolerates pH 6.0-8.0; tolerates pH 8.5; Grows optimally at pH 7.0.
  • 🌡
  • Temperature tolerance:
  • grows at 15℃; grows at 45℃; Grows optimally at 37℃.
  • H+
  • Acid from carbohydrates usually produced:
  • arabinose; fructose; galactose; glucose; mannose; rhamnose; ribose; xylose; amygdalin; starch; cellubiose; lactose; maltose; melezitose; melibiose; raffinose; sucrose; trehalose; sorbitol; salicin;
    • SPECIAL FEATURES (Kaur2014); (Steer2001); (Rainey2011gBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; ethanol; COâ‚‚; Hâ‚‚;
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • VP test:
  • not active
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Goldstein2018a); (Goldstein2014); (Goldstein2013b); (Tyrrell2012); (Goldstein2006); (Goldstein2006c);
    Class Active Resistant
  • Penicillins:
  • ampicillin; ampicillin-sulbactam; ertapenem; imipenem; meropenem; penicillin G;
  • piperacillin-tazobactam;
  • Cephalosporins:
  • ceftazidime;
  • Macrolides:
  • fidaxomicin;
  • Tetracyclines:
  • tigecycline;
  • Quinolines:
  • levofloxacin;
  • Heterocycles:
  • metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin; linezolid;

  • Steer, T., Collins, M. D., Gibson, G. R., Hippe, H., & Lawson, P. A. (2001). Clostridium hathewayi sp. nov., from human faeces. Systematic and Applied Microbiology, 24(3), 353–357.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Clostridiaceae Genus:  Hungatella Alt. name:  Clostridium hathewayi Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  Endospore Motility:  Swimming Morphology:  Rod
    Health:  Unknown
    Source:  human faeces, blood and atherosclerotic plaques
    DNA G+C(%):  50.9
    Opt. T:  37℃
    Low T(℃):  15(+)
    High T(℃):  45(+)
    NaCl 0.5-2%:  0.5-2.0(+)
    NaCl 3-5%:  2.5(+)
    Opt. pH:  7.0
    pH 4.2-5.9:  5(+)
    pH 6.0-8.0:  6.0-8.0(+)
    pH >8:  8.5(+)
    		Aesculin:  + Urea:  neg Gelatin:  neg Starch:  + Casein:  neg Tween:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  + Fructose:  + Galactose:  + Glucose:  + Mannose:  + Rhamnose:  + Ribose:  + Xylose:  + Cellubiose:  + Lactose:  + Maltose:  + Melezitose:  + Melibiose:  + Sucrose:  + Trehalose:  + Amygdalin:  + Cellulose:  neg Glycogen:  neg Inulin:  neg Starch:  + Mannitol:  neg Sorbitol:  + Salicin:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg α-Fucosidase:  neg PyrrolidAA:  neg Lecithinase:  neg Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Ethanol:  + CO2:  + H2:  + Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    ampicillin:  S(MIC50): 0.5, MIC90: 1, RNG: (0.25–>8)
    amp-sulb:  S(MIC50): 1, MIC90: 1, RNG: (0.125-8)
    penicillin:  Var(MIC50): 1, MIC90: 4, RNG: (0.5->4)
    penicillin_G:  S(MIC50): 1, MIC90: 16, RNG: (0.25–>32)
    piper-taz:  R(MIC50): 8, MIC90: 16, RNG: (0.5-64)
    ertapenem:  S(MIC50): 2, MIC90: 4, RNG: (0.125-4)
    imipenem:  S(MIC50): 0.25, MIC90: 2, RNG: (0.03–2)
    meropenem:  S(MIC50): 0.5, MIC90: 2, RNG: (0.25–4)
    cefoxitin:  Var(MIC50): 4, MIC90: 4, RNG: (1-8)
    ceftazidime:  R(MIC50): 32, MIC90: >128, RNG: (16–>128)
    fidaxomicin:  R(32)
    linezolid:  S(MIC50): 4, MIC90: 4, RNG: (2–>8)
    levofloxacin:  R(MIC50): 16, MIC90: 16, RNG: (1-16)
    moxifloxacin:  Var(MIC50): 8, MIC90: 8, RNG: (0.5-8)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  Var(MIC50): 4, MIC90: 16, RNG: (2–16)
    tigecycline:  S(MIC50): 0.06, MIC90: 0.06, RNG: (0.06–0.125)
    vancomycin:  S(MIC50): 1, MIC90: 1, RNG: (0.5–1.0)
    chloramphenicol:  Var(MIC50): 2, MIC90: 4, RNG: (1-32)
    metronidazole:  S(MIC50): 0.25, MIC90: 0.5, RNG: (0.06-2)
    clindamycin:  S(MIC50): 0.5, MIC90: 1.5, RNG: (0.06-32)
    daptomycin:  Var(MIC50): 2, MIC90: 8, RNG: (0.125–8)

    References

    SPECIFIC REFERENCES FOR HUNGATELLA HATHEWAYI
  • Browne2016 - Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.
  • Kaur2014 - Hungatella effluvii gen. nov., sp. nov., an obligately anaerobic bacterium isolated from an effluent treatment plant, and reclassification of Clostridium hathewayi as Hungatella hathewayi gen. nov., comb. nov.
  • SelberHnatiw2020 - Metabolic networks of the human gut microbiota.
  • Feng2015 - Gut microbiome development along the colorectal adenoma-carcinoma sequence
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • Finegold2010 - Pyrosequencing study of fecal microflora of autistic and control children
  • Giongo2011 - Toward defining the autoimmune microbiome for type 1 diabetes
  • Huang2019 - Analysis of microbiota in elderly patients with Acute Cerebral Infarction
  • Huang2019a - Metagenome-wide association study of the alterations in the intestinal microbiome composition of ankylosing spondylitis patients and the effect of traditional and herbal treatment
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • Qin2012 - Metagenome-wide association study of gut microbiota in type 2 diabetes
  • Takeshita2016 - A Single Species of Clostridium Subcluster XIVa Decreased in Ulcerative Colitis Patients
  • Ventura2019 - Gut microbiome of treatment-naïve MS patients of different ethnicities early in disease course
  • Yu2015 - Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer
  • Zuo2020 - Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization
  • Luna2016 - Distinct Microbiome-Neuroimmune Signatures Correlate With Functional Abdominal Pain in Children With Autism Spectrum Disorder.
  • Goldstein2018a - Comparative In Vitro Activities of Relebactam, Imipenem, the Combination of the Two, and Six Comparator Antimicrobial Agents against 432 Strains of Anaerobic Organisms, Including Imipenem-Resistant Strains.
  • Goldstein2014 - Comparative in vitro activities of SMT19969, a new antimicrobial agent, against 162 strains from 35 less frequently recovered intestinal Clostridium species: implications for Clostridium difficile recurrence.
  • Goldstein2013b - Comparative in vitro activities of GSK2251052, a novel boron-containing leucyl-tRNA synthetase inhibitor, against 916 anaerobic organisms.
  • Tyrrell2012 - In vitro activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic, against 377 strains of anaerobic bacteria and 34 strains of Corynebacterium species.
  • Goldstein2006 - In vitro activity of moxifloxacin against 923 anaerobes isolated from human intra-abdominal infections.
  • Goldstein2006c - Comparative in vitro susceptibilities of 396 unusual anaerobic strains to tigecycline and eight other antimicrobial agents.
  • Steer2001 - Clostridium hathewayi sp. nov., from Human Faeces.
  • Rainey2011gBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Clostridiaceae, Genus I. Clostridium - Cluster XIVa
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR HUNGATELLA HATHEWAYI
  • Browne2016 - Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • LeChatelier2013 - Richness of human gut microbiome correlates with metabolic markers
  • McLaughlin2010 - The bacteriology of pouchitis: a molecular phylogenetic analysis using 16S rRNA gene cloning and sequencing.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • Nielsen2014 - MetaHIT Consortium. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.
  • PerezBrocal2015 - Metagenomic Analysis of Crohn's Disease Patients Identifies Changes in the Virome and Microbiome Related to Disease Status and Therapy, and Detects Potential Interactions and Biomarkers
  • Pfleiderer2013 - Culturomics identified 11 new bacterial species from a single anorexia nervosa stool sample.
  • Qin2012 - Metagenome-wide association study of gut microbiota in type 2 diabetes
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Rothschild2018 - Environment dominates over host genetics in shaping human gut microbiota.
  • Tyakht2013 - Human gut microbiota community structures in urban and rural populations in Russia.
  • Walker2011 - High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • ...............................
    • GENERAL REFERENCES FOR HUNGATELLA HATHEWAYI
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
  • Alkhalil2017 - Bacterial involvements in ulcerative colitis: molecular and microbiological studies
    • Added: April 08, 2021