Intestinibacter bartlettii

(aka Clostridium bartlettii)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Intestinibacter bartlettii, (aka Clostridium bartlettii), is a Gram-positive, spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 24 gut microbiome compilation studies or metastudies. The DNA G+C content is 29.8%. Intestinibacter bartlettii is often a widespread coloniser of gut. (Gerritsen2014; Song2004a; Rainey2011fBergey)



  • This organism has been recovered from human faeces. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal. Robust growth can have positive consequences for gut health.
    • QUIRKS
  • Higher than normal levels have been associated with neurodevelopmental disorders in children (see Bojovic2020).
    • GENERAL CHARACTERISTICS (Gerritsen2014); (Song2004a); (Rainey2011fBergey);
    Character Response
  • Substrates hydrolysed or digested:
  • meat;
  • ±
  • Strain-dependent hydrolysis or digestion:
  • milk;
  • 💧
  • Bile tolerance:
  • Resistant to 20% bile
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; glucose; ribose; maltose; sucrose; mannitol;
  • ⥅
  • Substrates assimilated or utilised:
  • cellubiose; dextrin; fructose; gentiobiose; glucose; maltose; maltotriose; mannitol; sucrose; trehalose; D-turanose; alanine; methionine; phenylalanine; serine; threonine; pyruvate; methyl-β-glucoside; palatinose; alaninamide; α-ketobutyrate; methyl pyruvate; D-glucose-6-phosphate;
  • Active enzymes:
  • acid phosphatase; α-glucosidase; β-glucosidase; β-glucuronidase;
  • ±
  • Strain-dependent active enzymes:
  • alkaline phosphatase; β-galactosidase;
    • SPECIAL FEATURES (Gerritsen2014); (Song2004a); (Rainey2011fBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; lactate (minor); isobutyrate; isovalerate;
  • ✗
  • Metabolites not produced:
  • indole;
  • Haemolysis:
  • beta
  • ✗
  • Nitrate:
  • not reduced
  • ✗
  • NO3➔NO2:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Goldstein2014); (Song2004a);
    Class Active Resistant
  • Penicillins:
  • imipenem;
  • Cephalosporins:
  • cefoxitin;
  • Macrolides:
  • fidaxomicin;
  • Aminoglycosides:
  • kanamycin;
  • Polypep/ketides:
  • bacitracin;
  • Heterocycles:
  • metronidazole;
  • trimethoprim-sulfamethoxazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin;
  • colistin;

  • Song, Y. L., Liu, C. X., McTeague, M., Summanen, P., & Finegold, S. M. (2004). Clostridium bartlettii sp. nov., isolated from human faeces. Anaerobe, 10(3), 179–184.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Clostridiaceae Genus:  Intestinibacter Alt. name:  Clostridium bartlettii Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  Endospore Motility:  Sessile Morphology:  Rod
    Health:   Positive
    Source:  human faeces
    DNA G+C(%):  29.8
    Bile reaction(%):  20(+)
    		Aesculin:  neg Urea:  neg Gelatin:  neg Starch:  neg Milk:  d Meat:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Fructose:  + Glucose:  + Mannose:  neg Ribose:  + Xylose:  neg Lactose:  neg Maltose:  + Melezitose:  neg Melibiose:  neg Sucrose:  + Mannitol:  + Salicin:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Fructose:  + Glucose:  + Mannose:  vr Cellubiose:  + Gentiobiose:  + Maltose:  + Maltotriose:  + Sucrose:  + D-Turanose:  + Trehalose:  + Dextrin:  + Mannitol:  + Ala:  + Met:  + Phe:  + Ser:  + Thr:  + Pyruvate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  d α-Glucosidase:  + β-Glucosidase:  + β-Glucuronidase:  + ArgDH:  neg GluDC:  neg AlanineAA:  neg GluGluAA:  neg GlyAA:  neg LeuAA:  neg LeuGlyAA:  neg PyrrolidAA:  neg AlkalineP:  d(w) AcidP:  + Lecithinase:  neg Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Lactate:  minor(+) Isobutyrate:  + Isovalerate:  + Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    ampicillin:  I(1)
    imipenem:  S(4)
    cefoxitin:  S(2)
    kanamycin:  S(1000; disc)
    fidaxomicin:  S(0.03)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    vancomycin:  S(4)
    bacitracin:  S(2)
    metronidazole:  S(1)
    SXT:  R(>64)
    clindamycin:  S(0.25)
    colistin:  R(10; disc)

    References

    SPECIFIC REFERENCES FOR INTESTINIBACTER BARTLETTII
  • Bojovic2020 - Gut Microbiota Dysbiosis Associated With Altered Production of Short Chain Fatty Acids in Children With Neurodevelopmental Disorders
  • DeAngelis2013 - Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified
  • Debyser2016 - Faecal proteomics: A tool to investigate dysbiosis and inflammation in patients with cystic fibrosis
  • ElMouzan2018 - Microbiota profile in new-onset pediatric Crohn's disease: data from a non-Western population
  • Ventura2019 - Gut microbiome of treatment-naïve MS patients of different ethnicities early in disease course
  • Zhong2019 - Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naïve type 2 diabetics
  • Goldstein2014 - Comparative in vitro activities of SMT19969, a new antimicrobial agent, against 162 strains from 35 less frequently recovered intestinal Clostridium species: implications for Clostridium difficile recurrence.
  • Gerritsen2014 - Characterization of Romboutsia ilealis gen. nov., sp. nov., isolated from the gastro-intestinal tract of a rat, and proposal for the reclassification of five closely related members of the genus Clostridium into the genera Romboutsia gen. nov., Intestinibacter gen. nov., Terrisporobacter gen. nov. and Asaccharospora gen. nov.
  • Song2004a - Clostridium bartlettii sp. nov., isolated from human faeces.
  • Rainey2011fBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Clostridiaceae, Genus I. Clostridium - Cluster XI
  • Coretti2018 - Gut Microbiota Features in Young Children With Autism Spectrum Disorders
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR INTESTINIBACTER BARTLETTII
  • Browne2016 - Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • Chung2016 - Modulation of the human gut microbiota by dietary fibres occurs at the species level.
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jeong2021 - The effect of taxonomic classification by full-length 16S rRNA sequencing with a synthetic long-read technology
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • Karlsson2013 - Gut metagenome in European women with normal, impaired and diabetic glucose control
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • McLaughlin2010 - The bacteriology of pouchitis: a molecular phylogenetic analysis using 16S rRNA gene cloning and sequencing.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • Nielsen2014 - MetaHIT Consortium. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.
  • Qin2012 - Metagenome-wide association study of gut microbiota in type 2 diabetes
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Rothschild2018 - Environment dominates over host genetics in shaping human gut microbiota.
  • Tyakht2013 - Human gut microbiota community structures in urban and rural populations in Russia.
  • Walker2011 - High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease.
  • Wang2018 - A metagenome-wide association study of gut microbiota in asthma in UK adults
  • Wang2018a - Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model.
  • Wang2020a - Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • ...............................
    • GENERAL REFERENCES FOR INTESTINIBACTER BARTLETTII
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: April 08, 2021