Intestinimonas butyriciproducens

(aka Clostridium anorexicus)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Intestinimonas butyriciproducens, (aka Clostridium anorexicus), is a Gram-positive, spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 11 gut microbiome compilation studies or metastudies. The DNA G+C content is 59.1%. Intestinimonas butyriciproducens is a common gut coloniser. (Klaring2013; Pfleiderer2013)



  • This organism has been recovered from human faeces , and mouse caeca. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal.
    • QUIRKS
  • In 94% of Europeans (unseenbio.com).
    • GENERAL CHARACTERISTICS (Klaring2013); (Pfleiderer2013);
    Character Response
  • 🌡
  • Temperature tolerance:
  • grows at 25℃; grows at 45℃;
  • ⥅
  • Substrates assimilated or utilised:
  • N-acetylglucosamine; dextrin; galactose; glucose; maltotriose; sorbitol; D-turanose; serine; threonine; 3-hydroxybutyrate; DL-lactate; pyruvate; methyl D-lactate; thymidine; uridine; inosine; TMP; UMP; D-glucose-6-phosphate;
    • SPECIAL FEATURES (Klaring2013);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; butyrate (major); lactate (minor); valerate (minor); isobutyrate; ethanol; isovalerate (minor);
    • RESPONSE TO ANTIBIOTICS (Klaring2013);
    Class Active Resistant
  • Penicillins:
  • oxacillin;
  • Cephalosporins:
  • cefotaxime;
  • Macrolides:
  • erythromycin;
  • Tetracyclines:
  • tetracycline;
  • Quinolines:
  • ciprofloxacin;
  • Heterocycles:
  • chloramphenicol; metronidazole;
  • sulfamethoxazole;
  • Vancomycins:
  • vancomycin; teicoplanin;
  • Miscellaneous antibiotics:
  • clindamycin;
  • colistin;

  • N/A

  • Several resistance mechanisms appear to be encoded by the genomes of the strain. Intestinimonas butyriciproducens converts lysine into butyrate, which is an energy source for colonocytes, and releases ammonium, which can be used as nitrogen source by bacteria and neutralises acidity created by short-chain fatty acid production. [PMID: 27717172]

  • GutFeeling KnowledgeBase COMMENTS [Website]

    Intestinimonas is a newly described bacterial genus with representative strains present in the intestinal tract of human and other animals. Despite unique metabolic features including the production of butyrate from both sugars and amino acids, there is to date no data on their diversity, ecology, and physiology. [PMID: 27717172]

  • Pfleiderer, A., Lagier, J.-C., Armougom, F., Robert, C., Vialettes, B., & Raoult, D. (2013). Culturomics identified 11 new bacterial species from a single anorexia nervosa stool sample. European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology, 32(11), 1471–1481.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  unclassified Clostridiales Genus:  Intestinimonas Alt. name:  Clostridium anorexicus Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  Endospore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces , and mouse caeca
    DNA G+C(%):  59.1
    Lower T(℃):  25(+)
    High T(℃):  45(+)
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Fructose:  neg Fucose:  neg Galactose:  + Glucose:  + Gentiobiose:  neg Maltose:  neg Maltotriose:  + D-Turanose:  + N_Acetyl_glucosamine:  + Dextrin:  + Dulcitol:  neg Mannitol:  neg Sorbitol:  + Ala:  neg Ser:  + Thr:  + 3-Hydroxybutyrate:  + DL-Lactate:  + Pyruvate:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    oxacillin:  S(0.75)
    cefotaxime:  S(0.029)
    tobramycin:  Var(MIC50): 2), MIC90: Var(2
    erythromycin:  S(0.10)
    ciprofloxacin:  R(>32)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  R(>256)
    teicoplanin:  S(0.029)
    vancomycin:  S(0.48)
    chloramphenicol:  S(0.75)
    metronidazole:  S(0.016)
    sulfamethoxazole:  R(>32)
    clindamycin:  S(0.022)
    colistin:  R(30)

    References

    SPECIFIC REFERENCES FOR INTESTINIMONAS BUTYRICIPRODUCENS
  • Klaring2013 - Intestinimonas butyriciproducens gen. nov., sp. nov., a butyrate-producing bacterium from the mouse intestine.
  • Pfleiderer2013 - Culturomics identified 11 new bacterial species from a single anorexia nervosa stool sample.
  • Bui2015 - Production of butyrate from lysine and the Amadori product fructoselysine by a human gut commensal.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR INTESTINIMONAS BUTYRICIPRODUCENS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Jeong2021 - The effect of taxonomic classification by full-length 16S rRNA sequencing with a synthetic long-read technology
  • King2019 - Baseline human gut microbiota profile in healthy people and standard reporting template.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • Pfleiderer2013 - Culturomics identified 11 new bacterial species from a single anorexia nervosa stool sample.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Wang2020a - Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • ...............................
    • GENERAL REFERENCES FOR INTESTINIMONAS BUTYRICIPRODUCENS
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: February 08, 2021