Klebsiella variicola

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Klebsiella variicola is a Gram-negative, non-spore-forming, facultatively anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 9 gut microbiome compilation studies or metastudies. Klebsiella variicola is probably a common, although minor, coloniser of the gut. (Rosenblueth2004)



  • This organism has been recovered from human faeces (infant - CCUG), clinical (wound, blood, urine - CCUG) and plant sources. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: human and animal pathogen). Is a known human pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Rosenblueth2004);
    Character Response
  • pH
  • Acidity tolerance:
  • tolerates pH 5.6; tolerates pH 7;
  • 🌡
  • Temperature tolerance:
  • grows at 37℃;
  • H+
  • Acid from carbohydrates usually produced:
  • arabinose; glucose; rhamnose; amygdalin; sucrose; inositol; mannitol; sorbitol;
  • ⥅
  • Substrates assimilated or utilised:
  • melibiose;
    • SPECIAL FEATURES (Rosenblueth2004);
    Character Response
  • ✗
  • Metabolites not produced:
  • H₂S; indole;
  • ✓
  • VP test:
  • active
  • Pigments:
  • yellow
    • RESPONSE TO ANTIBIOTICS (Rosenblueth2004);
    Class Active Resistant
  • Penicillins:
  • ampicillin; carbenicillin; ticarcillin;
  • Quinolines:
  • nalidixic-acid;
  • Aminoglycosides:
  • gentamicin; spectinomycin;

  • N/A

  • Infections caused by K. variicola have been reported in humans worldwide and less frequently in wild and farm animal infections. Additionally, K. variicola is frequently isolated from a wide range of plant ecosystems, playing a role in nitrogen fixation and plant growth promotion. [PMID: 31259664]

  • GutFeeling KnowledgeBase COMMENTS [Website]

    Bacteria of the genus Klebsiella are widely distributed in nature, in the soil and in water. They are also part of the normal flora of the human intestinal tract, but usually in low numbers compared with E. coli. Klebsiella variicola is a recently (2004) described species distributed both in plants and in clinical settings, representing less than 10% of the clinical Klebsiella isolates previously considered as K. pneumoniae. Amazonian leaf-cutter ants cut leaves and bring them to a fungal garden, which they use as a substrate to cultivate a fungus (family Lepiotaceae) for food. Additionally these ants engage in another association with Actinobacteria (genus Pseudonocardia), which produce antibiotics to help defend the fungus garden from parasites. It has now been discovered that N(2) fixation occurs in leaf-cutter ant fungus gardens and indicated the presence of N(2)-fixing bacteria within the garden matrix. It is estimated that a single mature leaf-cutter ant colony may contribute as much as 1.8 kg of fixed N per year into neotropical ecosystems (adapted from PMID 19965433). [UP000001907]

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Proteobacteria Class:  Gammaproteobacteria Order:  Enterobacterales Family:  Enterobacteriaceae Genus:  Klebsiella Gram stain:  neg O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod Pigment:  yellow
    Health:  Unknown
    Source:  human faeces (infant - CCUG), clinical (wound, blood, urine - CCUG) and plant sources
    Mid T(℃):  37(+)
    pH 4.2-5.9:  5.6(+)
    pH 6.0-8.0:  7(+)
    		Urea:  vr Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  + Glucose:  + Rhamnose:  + Sucrose:  + Amygdalin:  + Adonitol:  neg Inositol:  + Mannitol:  + Sorbitol:  +
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Melibiose:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Urease:  vr β-Galactosidase:  vr ArgDH:  neg LysDC:  vr OrnDC:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		H2S:  neg Indole:  neg Pigment:  yellow
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    ampicillin:  Res
    carbenicil:  Res
    ticarcillin:  Res
    gentamicin:  S(10)
    spectinomycin:  S(250; disc)
    nalidixic-acid:  Sens
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)

    References

    SPECIFIC REFERENCES FOR KLEBSIELLA VARIICOLA
  • Rosenblueth2004 - Klebsiella variicola, A Novel Species with Clinical and Plant-Associated Isolates.
  • Wang2019b - Alterations in the human gut microbiome associated with Helicobacter pylori infection
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR KLEBSIELLA VARIICOLA
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • King2019 - Baseline human gut microbiota profile in healthy people and standard reporting template.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • Nielsen2014 - MetaHIT Consortium. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.
  • Wang2020a - Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
  • ...............................
    • GENERAL REFERENCES FOR KLEBSIELLA VARIICOLA
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
    • Added: February 08, 2021