Lachnoanaerobaculum saburreum

(aka Eubacterium saburreum)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Lachnoanaerobaculum saburreum, (aka Eubacterium saburreum), is a Gram-positive, spore-forming, strictly anaerobic, rod-shaped bacterium. It has been detected in at least 5 gut microbiome compilation studies or metastudies. The DNA G+C content is 37.0%. Lachnoanaerobaculum saburreum is probably a rare gut coloniser. (Hedberg2012; Wade2011aBergeys)



  • This organism has been recovered from dental disease and human faeces. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread (notes: opportunistic in immunocompromised patients). Can cause opportunistic infections, particularly in immunocompromised people. Likely to be transient and not a long-term gut commensal.
    • GENERAL CHARACTERISTICS (Hedberg2012); (Wade2011aBergeys);
    Character Response
  • pH
  • Acidity tolerance:
  • Grows optimally at pH 6.5-7.5.
  • 🌡
  • Temperature tolerance:
  • Grows optimally at 37℃.
  • H+
  • Acid from carbohydrates usually produced:
  • arabinose; glucose; xylose; lactose; maltose; sucrose; trehalose;
  • Active enzymes:
  • fucosidase; α-galactosidase; β-galactosidase; α-glucosidase; β-glucosidase; pyroGlu arylamidase;
    • SPECIAL FEATURES (Hedberg2012); (Wade2011aBergeys);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; butyrate (major); lactate; H₂S; ammonia; indole;
  • ✗
  • Haemolysis:
  • absent
  • ✓
  • Nitrate:
  • reduced
    • RESPONSE TO ANTIBIOTICS (Hedberg2012); (Wade2011aBergeys);
    Class Active Resistant
  • Penicillins:
  • amoxicillin; amoxicillin-clavulanic acid; ertapenem; penicillin G;
  • Cephalosporins:
  • cefalexin;
  • Macrolides:
  • azithromycin; erythromycin;
  • Tetracyclines:
  • doxycycline;
  • Quinolines:
  • ciprofloxacin; levofloxacin;
  • Aminoglycosides:
  • kanamycin;
  • Heterocycles:
  • metronidazole;
  • Vancomycins:
  • vancomycin; dalbavancin;
  • Miscellaneous antibiotics:
  • clindamycin;
  • colistin;

  • Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007). Development of the human infant intestinal microbiota. PLoS Biology, 5(7), e177.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Lachnospiraceae Genus:  Lachnoanaerobaculum Alt. name:  Eubacterium saburreum Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  Endospore Morphology:  Rod
    Health:  Unknown
    Source:  dental disease and human faeces
    DNA G+C(%):  37.0
    Opt. T:  37℃
    Opt. pH:  6.5-7.5
    		Urea:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  + Glucose:  + Mannose:  neg Xylose:  + Lactose:  + Maltose:  + Sucrose:  + Trehalose:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  + α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  + β-Glucuronidase:  neg ArgDH:  neg GluDC:  neg AlanineAA:  neg GluGluAA:  neg GlyAA:  neg LeuAA:  neg LeuGlyAA:  neg PyrrolidAA:  neg PyrogluAA:  + AlkalineP:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Butyrate:  Major(+) Lactate:  + H2S:  + Ammonia:  + Indole:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  S(0.5)
    Augmentin:  S(MIC50): 0.06, MIC90: 0.125, RNG: (≤0.015-0.125)
    penicillin_G:  S(MIC50): 0.06, MIC90: 0.125, RNG: (≤0.03-0.125)
    piper-taz:  Var(MIC50): 0.02, MIC90: 16, RNG: (0.02-16)
    ertapenem:  S(0.06/0.5)
    cefalexin:  R(MIC50): 32, MIC90: >32, RNG: (8->32)
    kanamycin:  S(1000)
    azithromycin:  S(MIC50): 0.06, MIC90: 0.125, RNG: (≤0.03-0.125)
    erythromycin:  S(MIC50): 0.06, MIC90: 0.06, RNG: (≤0.03-0.06)
    quin-dalf:  Var(MIC50): 2, MIC90: 4, RNG: (0.02-1)
    linezolid:  Var(MIC50): 2, MIC90: 4, RNG: (0.25-8)
    ciprofloxacin:  R(MIC50): 8, MIC90: >8, RNG: (≤0.5->8)
    levofloxacin:  R(MIC50): 8, MIC90: >8, RNG: (0.25->8)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(0.5)
    tetracycline:  Var(MIC50): 0.5, MIC90: 16, RNG: (0.125-16)
    dalbavancin:  S(MIC50): 0.25, MIC90: 1, RNG: (0.06-2)
    vancomycin:  S(MIC50): 0.5, MIC90: 2, RNG: (0.25-2)
    metronidazole:  S(MIC50): 0.06, MIC90: 0.25, RNG: (0.06-0.5)
    clindamycin:  S(MIC50): 0.25, MIC90: 0.25, RNG: (≤0.03-0.25)
    daptomycin:  Var(MIC50): 0.5, MIC90: 16, RNG: (0.06->32)
    colistin:  R(10)

    References

    SPECIFIC REFERENCES FOR LACHNOANAEROBACULUM SABURREUM
  • Hedberg2012 - Lachnoanaerobaculum gen. nov., a new genus in the Lachnospiraceae : characterization of Lachnoanaerobaculum umeaense gen. nov., sp. nov., isolated from the human small intestine, and Lachnoanaerobaculum orale sp. nov., isolated from saliva, and reclassification of Eubacterium saburreum (Prevot 1966) Holdeman and Moore 1970 as Lachnoanaerobaculum saburreum comb. nov.
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • Wade2011aBergeys - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Eubacteriaceae, Genus I. Eubacterium
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR LACHNOANAEROBACULUM SABURREUM
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Qin2012 - Metagenome-wide association study of gut microbiota in type 2 diabetes
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • ...............................
    • GENERAL REFERENCES FOR LACHNOANAEROBACULUM SABURREUM
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: April 08, 2021