Lacrimispora celerecrescens

(aka Clostridium celerecrescens)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Lacrimispora celerecrescens, (aka Clostridium celerecrescens), is a Gram-positive, spore-forming, strictly anaerobic, motile, rod-shaped - curved bacterium. It has been detected in at least 2 gut microbiome compilation studies or metastudies. The DNA G+C content is 38%. Lacrimispora celerecrescens is probably a rare gut coloniser. (Rainey2011gBergey; Palop1989; Chamkha2001a)



  • This organism has been recovered from cow manure and clinical sources (eye, osteitis - CCUG). NE90 - a related bacterium (S16 94%) - was detected in human faeces. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Could be a possible pathogen in humans, but unknown at this stage. A possible gut commensal.
    • QUIRKS
  • Cellulolytic.
    • GENERAL CHARACTERISTICS (Rainey2011gBergey); (Palop1989); (Chamkha2001a);
    Character Response
  • Substrates hydrolysed or digested:
  • milk;
  • pH
  • Acidity tolerance:
  • Grows optimally at pH 7.
  • 🌡
  • Temperature tolerance:
  • Grows optimally at 30-37℃.
  • H+
  • Acid from carbohydrates usually produced:
  • arabinose; fructose; galactose; glucose; mannose; rhamnose; ribose; sorbose; xylose; cellulose; aesculin; cellubiose; lactose; maltose; melezitose; melibiose; raffinose; sucrose; trehalose; adonitol; mannitol;
    • SPECIAL FEATURES (Rainey2011gBergey); (Palop1989); (Chamkha2001a);
    Character Response
  • ✓
  • Metabolites produced:
  • formate; acetate; butyrate; lactate; isobutyrate; ethanol; succinate; isovalerate; caproate; CO₂; H₂; indole;
  • ✗
  • VP test:
  • not active
  • ✗
  • Nitrate:
  • not reduced
  • ✗
  • Sulfate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Goldstein2014); (Goldstein2013);
    Class Active Resistant
  • Penicillins:
  • imipenem; piperacillin-tazobactam;
  • Macrolides:
  • fidaxomicin;
  • Heterocycles:
  • metronidazole;
  • Vancomycins:
  • vancomycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Lachnospiraceae Genus:  Lacrimispora Alt. name:  Clostridium celerecrescens Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  Endospore Motility:  Swimming Morphology:  Rod - curved
    Health:  Unknown
    Source:  cow manure and clinical sources (eye, osteitis - CCUG). NE90 - a related bacterium (S16 94%) - was detected in human faeces
    DNA G+C(%):  38
    Opt. T:  30-37℃
    Opt. pH:  7
    		Urea:  neg Casein:  neg Milk:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  + Fructose:  + Galactose:  + Glucose:  + Mannose:  + Rhamnose:  + Ribose:  + Sorbose:  w(+) Xylose:  + Cellubiose:  + Lactose:  w(+) Maltose:  + Melezitose:  w(+) Melibiose:  w(+) Sucrose:  w(+) Trehalose:  + Cellulose:  + Aesculin:  + Inulin:  neg Starch:  neg Adonitol:  + Dulcitol:  neg Erythritol:  neg Glycerol:  neg Mannitol:  + Sorbitol:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg Lecithinase:  neg Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Formate:  + Acetate:  + Butyrate:  + Lactate:  + Isobutyrate:  + Ethanol:  + Succinate:  + Isovalerate:  + Caproate:  + CO2:  + H2:  + Indole:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    piper-taz:  S(MIC50): 0.25, MIC90: 4, RNG: (0.015–16)
    imipenem:  S(MIC50): 0.25, MIC90: 2, RNG: (0.03–2)
    fidaxomicin:  R(32)
    moxifloxacin:  Var(MIC50): 1, MIC90: 8, RNG: (0.25–32)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    vancomycin:  S(1)
    metronidazole:  S(MIC50): 0.25, MIC90: 2, RNG: (0.03–2)

    References

    SPECIFIC REFERENCES FOR LACRIMISPORA CELERECRESCENS
  • Goldstein2014 - Comparative in vitro activities of SMT19969, a new antimicrobial agent, against 162 strains from 35 less frequently recovered intestinal Clostridium species: implications for Clostridium difficile recurrence.
  • Goldstein2013 - In vitro activity of Biapenem plus RPX7009, a carbapenem combined with a serine β-lactamase inhibitor, against anaerobic bacteria.
  • Rainey2011gBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Clostridiaceae, Genus I. Clostridium - Cluster XIVa
  • Palop1989 - Isolation and Characterization of an Anaerobic, Cellulolytic Bacterium, Clostridium celerecrescens sp. nov.
  • Chamkha2001a - Metabolism of cinnamic acids by some Clostridiales and emendation of the descriptions of Clostridium aerotolerans, Clostridium celerecrescens and Clostridium xylanolyticum.
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR LACRIMISPORA CELERECRESCENS
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Zupancic2012 - Analysis of the Gut Microbiota in the Old Order Amish and Its Relation to the Metabolic Syndrome.
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    • Added: October 28, 2021