Lacticaseibacillus paragasseri

(aka Lactobacillus paragasseri)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Lacticaseibacillus paragasseri, (aka Lactobacillus paragasseri), is a Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 34.9%. Lacticaseibacillus paragasseri is likely to be transient and not a long-term gut coloniser. (Tanizawa2018)



  • This organism has been recovered from human faeces (Tanizawa2018). Pathogenicity status unknown, or very unlikely to be pathogenic. Likely to be transient and not a long-term gut commensal.
    • GENERAL CHARACTERISTICS (Tanizawa2018);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin;
  • 🧂
  • Salt tolerance:
  • tolerates 2% salt; doesn't tolerate 4% salt;
  • pH
  • Acidity tolerance:
  • tolerates pH 4.2-5.9; tolerates pH 6.0-8.0;
  • 🌡
  • Temperature tolerance:
  • grows at 10℃; grows at 40℃; strain-variable at 45(d);
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; galactose; glucose; mannose; D-tagatose; amygdalin; aesculin; starch; cellubiose; gentiobiose; lactose; maltose; sucrose; trehalose; arbutin; N-Ac glucosamine; salicin;
  • Active enzymes:
  • acid phosphatase; N-Ac β-glucosaminidase; esterase C4; β-glucosidase; leucine aminopeptidase; valine aminopeptidase; naphthol-ASBI-P;
  • ±
  • Strain-dependent active enzymes:
  • esterase lipase C8; α-galactosidase; β-galactosidase; α-glucosidase; β-glucuronidase;
    • SPECIAL FEATURES (Tanizawa2018);
    Character Response
  • ✓
  • Metabolites produced:
  • lactate;
  • ✗
  • Metabolites not produced:
  • H₂S; indole;
    • RESPONSE TO ANTIBIOTICS (Tyrrell2012);
    Class Active Resistant
  • Penicillins:
  • ampicillin; imipenem; piperacillin-tazobactam;
  • Heterocycles:
  • metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • daptomycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Bacilli Order:  Lactobacillales Family:  Lactobacillaceae Genus:  Lacticaseibacillus Alt. name:  Lactobacillus paragasseri Gram stain:  + O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces (Tanizawa2018)
    DNA G+C(%):  34.9
    Low T(℃):  10(+)
    Mid T(℃):  40(+)
    High T(℃):  45(d)
    NaCl 0.5-2%:  2(+)
    NaCl 3-5%:  4(neg)
    pH 4.2-5.9:  4.2-5.9(+)
    pH 6.0-8.0:  6.0-8.0(+)
    		Aesculin:  + Gelatin:  neg Casein:  neg Arginine:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg D-Arabinose:  neg L-Arabinose:  neg Fructose:  + Fucose:  neg D-Fucose:  neg Galactose:  + Glucose:  + Mannose:  + D-Lyxose:  neg Rhamnose:  neg Ribose:  neg Sorbose:  neg D-Tagatose:  + Xylose:  neg L-Xylose:  neg Cellubiose:  + Gentiobiose:  + Lactose:  + Maltose:  + Melezitose:  neg Melibiose:  neg Sucrose:  + Trehalose:  + Turanose:  vr Amygdalin:  + Aesculin:  + Glycogen:  neg Inulin:  neg Starch:  + Adonitol:  neg D-Arabitol:  neg L-Arabitol:  neg Dulcitol:  neg Erythritol:  neg Glycerol:  neg Inositol:  neg Mannitol:  neg Sorbitol:  neg Xylitol:  neg Arbutin:  + Gluconate:  neg 2-Ketogluconate:  neg 5-Ketogluconate:  neg Me-α-D-Glc:  vr Me-α-D-Mann:  neg Me-Xyloside:  neg NAc-α-GA:  + Salicin:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg Ac-β-glcamnd:  + α-Fucosidase:  neg α-Galactosidase:  d β-Galactosidase:  d α-Glucosidase:  d β-Glucosidase:  + β-Glucuronidase:  d α-Mannosidase:  neg Chymotrypsin:  neg LeuAP:  + Trypsin:  neg ValAP:  + AlkalineP:  neg AcidP:  + Esterase(C4):  + EstLip(C8):  d Lipase(C14):  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Lactate:  + H2S:  neg Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    ampicillin:  S(MIC50): 0.5, MIC90: 2, RNG: (0.03–8)
    piper-taz:  S(MIC50): 1, MIC90: 4, RNG: (0.03–16)
    imipenem:  S(MIC50): 0.25, MIC90: 2, RNG: (0.03–8)
    linezolid:  Var(MIC50): 4, MIC90: >8, RNG: (1–>8)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    vancomycin:  R(MIC50): >32, MIC90: >32, RNG: (0.25–>32)
    metronidazole:  R(MIC50): >32, MIC90: >32, RNG: (1–>32)
    daptomycin:  S(MIC50): 2, MIC90: 4, RNG: (0.25–>32)

    References

    SPECIFIC REFERENCES FOR LACTICASEIBACILLUS PARAGASSERI
  • Tyrrell2012 - In vitro activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic, against 377 strains of anaerobic bacteria and 34 strains of Corynebacterium species.
  • Tanizawa2018 - Lactobacillus paragasseri sp. nov., a sister taxon of Lactobacillus gasseri, based on whole-genome sequence analyses.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR LACTICASEIBACILLUS PARAGASSERI
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • ...............................
    • GENERAL REFERENCES FOR LACTICASEIBACILLUS PARAGASSERI
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
    • Added: July 12, 2021