Lactobacillus delbrueckii subsp. bulgaricus

(aka Lactobacillus bulgaricus)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Lactobacillus delbrueckii subsp. bulgaricus, (aka Lactobacillus bulgaricus), is a Gram-positive, non-spore-forming, microaerophilic, non-motile, rod-shaped bacterium. It has been detected in at least 4 gut microbiome compilation studies or metastudies. The DNA G+C content is 50%. Lactobacillus delbrueckii subsp. bulgaricus is probably a rare gut coloniser. (Weiss1983; Hammes2011Bergey)



  • This organism has been recovered from yoghurt and cheese; human faeces (Sanz2007 - healthy and coeliac children) and clinical sources (bile, vagina - CCUG). The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. Likely to be transient and not a long-term gut commensal. Robust growth can have positive consequences for gut health.
    • GENERAL CHARACTERISTICS (Weiss1983); (Hammes2011Bergey);
    Character Response
  • 🌡
  • Temperature tolerance:
  • doesn't grow at 15℃; grows at 48℃; Grows optimally at 40-44℃.
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; glucose; lactose;
  • ±
  • Strain-dependent acid from carbs:
  • cellubiose;
    • SPECIAL FEATURES (Weiss1983); (Hammes2011Bergey);
    Character Response
  • ✓
  • Metabolites produced:
  • lactate;
  • ✗
  • Metabolites not produced:
  • Hâ‚‚S; indole;
  • ✗
  • NO3➔NO2:
  • not reduced
    • RESPONSE TO ANTIBIOTICS
    Class Active Resistant
  • Tetracyclines:
  • tetracycline;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Bacilli Order:  Lactobacillales Family:  Lactobacillaceae Genus:  Lactobacillus Alt. name:  Lactobacillus bulgaricus Gram stain:  + O2 Relation.:  microaerophilic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:   Positive
    Source:  yoghurt and cheese; human faeces (Sanz2007 - healthy and coeliac children) and clinical sources (bile, vagina - CCUG)
    DNA G+C(%):  50
    Opt. T:  40-44℃
    Low T(℃):  15(neg)
    High T(℃):  48(+)
    		Gelatin:  neg Arginine:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg Fructose:  + Galactose:  neg Glucose:  + Mannose:  neg D-Lyxose:  neg Rhamnose:  neg Ribose:  neg Xylose:  neg Cellubiose:  d Lactose:  + Maltose:  neg Melezitose:  neg Melibiose:  neg Sucrose:  neg Trehalose:  neg Amygdalin:  neg Aesculin:  neg Mannitol:  neg Sorbitol:  neg Gluconate:  neg Salicin:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Lactate:  + H2S:  neg Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  R(15.6-125)

    References

    SPECIFIC REFERENCES FOR LACTOBACILLUS DELBRUECKII SUBSP. BULGARICUS
  • Weiss1983 - Lactobacillus lactis, Lactobacillus leichmannii and Lactobacillus bulgaricus, Subjective Synonyms of Lactobacillus delbrueckii, and Description of Lactobacillus delbrueckii subsp. lactis comb. nov. and Lactobacillus delbrueckii subsp. bulgaricus comb. nov.
  • Hammes2011Bergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Lactobacillaceae, Genus I. Lactobacillus
  • Le2013 - Alterations in fecal Lactobacillus and Bifidobacterium species in type 2 diabetic patients in Southern China population
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR LACTOBACILLUS DELBRUECKII SUBSP. BULGARICUS
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Tyakht2013 - Human gut microbiota community structures in urban and rural populations in Russia.
  • ...............................
    • GENERAL REFERENCES FOR LACTOBACILLUS DELBRUECKII SUBSP. BULGARICUS
  • Sanz2007 - Differences in faecal bacterial communities in coeliac and healthy children as detected by PCR and denaturing gradient gel electrophoresis
    • Added: October 28, 2021