Lactonifactor longoviformis

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Lactonifactor longoviformis is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 6 gut microbiome compilation studies or metastudies. The DNA G+C content is 48.0%. Lactonifactor longoviformis is probably a common, although minor, coloniser of the gut. (Clavel2007)



  • This organism has been recovered from human faeces. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. A possible gut commensal.
    • QUIRKS
  • In 56% of Europeans (unseenbio.com). Minor coloniser.
    • GENERAL CHARACTERISTICS (Clavel2007);
    Character Response
  • pH
  • Acidity tolerance:
  • tolerates pH 5.5; tolerates pH 6.0-8.0; tolerates pH 9.3;
  • ⥅
  • Substrates assimilated or utilised:
  • fructose; glucose; mannose; melezitose; melibiose; raffinose; sorbitol; sucrose;
  • Active enzymes:
  • arabinosidase; α-galactosidase; α-glucosidase;
    • SPECIAL FEATURES (Clavel2007);
    Character Response
  • ✗
  • Metabolites not produced:
  • indole;
    • RESPONSE TO ANTIBIOTICS (Clavel2007);
    Class Active Resistant
  • Penicillins:
  • penicillin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • metronidazole;
  • Vancomycins:
  • vancomycin;

  • Clavel, T., Lippman, R., Gavini, F., Doré, J., & Blaut, M. (2007). Clostridium saccharogumia sp. nov. and Lactonifactor longoviformis gen. nov., sp. nov., two novel human faecal bacteria involved in the conversion of the dietary phytoestrogen secoisolariciresinol diglucoside. Systematic and Applied Microbiology, 30(1), 16–26.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Lachnospiraceae Genus:  Lactonifactor Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces
    DNA G+C(%):  48.0
    pH 4.2-5.9:  5.5(+)
    pH 6.0-8.0:  6.0-8.0(+)
    pH >8:  9.3(+)
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Fructose:  + Glucose:  + Mannose:  + Melezitose:  + Melibiose:  + Raffinose:  + Sucrose:  + Sorbitol:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg α-Arab:  + α-Galactosidase:  + α-Glucosidase:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    penicillin:  S(0.5)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    vancomycin:  S(0.5)
    rifampicin:  S(0.5)
    metronidazole:  R(5)

    References

    SPECIFIC REFERENCES FOR LACTONIFACTOR LONGOVIFORMIS
  • Clavel2007 - Clostridium saccharogumia sp. nov. and Lactonifactor longoviformis gen. nov., sp. nov., two novel human faecal bacteria involved in the conversion of the dietary phytoestrogen secoisolariciresinol diglucoside.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR LACTONIFACTOR LONGOVIFORMIS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Jeong2021 - The effect of taxonomic classification by full-length 16S rRNA sequencing with a synthetic long-read technology
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • ...............................
    • GENERAL REFERENCES FOR LACTONIFACTOR LONGOVIFORMIS
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
    • Added: April 08, 2021