Legionella pneumophila

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Legionella pneumophila is a Gram-negative, non-spore-forming, aerobic, motile, rod-shaped bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 39-41%. Legionella pneumophila is unlikely to be a gut coloniser. (Brenner1979; Winn2005Bergey)



  • This organism has been recovered from lungs. Cause of legionellosis. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. Is a known human pathogen. Likely to be transient and not a long-term gut commensal.
    • GENERAL CHARACTERISTICS (Brenner1979); (Winn2005Bergey);
    Character Response
  • Substrates hydrolysed or digested:
  • gelatin; hippurate;
  • ⥅
  • Substrates assimilated or utilised:
  • cysteine;
  • Active enzymes:
  • catalase;
  • ±
  • Strain-dependent active enzymes:
  • oxidase;
    • SPECIAL FEATURES
    Character Response
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS
    Class Active Resistant
  • Macrolides:
  • azithromycin; clarithromycin;
  • Aminoglycosides:
  • tobramycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Proteobacteria Class:  Gammaproteobacteria Order:  Legionellales Family:  Legionellaceae Genus:  Legionella Gram stain:  neg O2 Relation.:  aerobic Spore:  No spore Motility:  Swimming Morphology:  Rod
    Health:  Unknown
    Source:  lungs. Cause of legionellosis
    DNA G+C(%):  39-41
    		Urea:  neg Gelatin:  + Hippurate:  +
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Cys:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  d Catalase:  + Urease:  neg ArgDH:  neg LysDC:  neg OrnDC:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    tobramycin:  SensRNG: (0.25-4)
    azithromycin:  SensRNG: (0.008-2)
    clarithromycin:  SensRNG: (0.001-0.125)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)

    References

    SPECIFIC REFERENCES FOR LEGIONELLA PNEUMOPHILA
  • Brenner1979 - Classification of the Legionnaires' disease bacterium: Legionella pneumophila, genus novum, species nova, of the family Legionellaceae, familia nova.
  • Winn2005Bergey - Bergey's manual of systematic bacteriology. Vol. 2, The Gammaproteobacteria Part B. Family Enterobacteriaceae, Genus XI. Edwardsiella
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR LEGIONELLA PNEUMOPHILA
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
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    • Added: January 14, 2022