Leptospira interrogans

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Leptospira interrogans is a Gram-negative, non-spore-forming, microaerophilic, motile, helical-shaped bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 35%. Leptospira interrogans is unlikely to be a gut coloniser. (Faine1982)



  • This organism has been recovered from kidneys. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: zoonotic pathogen). Is a known human pathogen. Likely to be transient and not a long-term gut commensal.
    • QUIRKS
  • Consumes no carbohydrates or amino acids, just lipids.
    • GENERAL CHARACTERISTICS (Faine1982);
    Character Response
  • pH
  • Acidity tolerance:
  • tolerates pH 6.8-7.8; Grows optimally at pH 7.2-7.6.
  • 🌡
  • Temperature tolerance:
  • doesn't grow at 13℃; doesn't grow at 40℃; Grows optimally at 28-30℃.
  • Active enzymes:
  • catalase; esterase; oxidase;
  • ±
  • Strain-dependent active enzymes:
  • lipase;
    • SPECIAL FEATURES
    Character Response

    Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Spirochaetes Class:  Spirochaetia Order:  Leptospirales Family:  Leptospiralaceae Genus:  Leptospira Gram stain:  neg O2 Relation.:  microaerophilic Spore:  No spore Motility:  Swimming Morphology:  Helical
    Health:  Unknown
    Source:  kidneys
    DNA G+C(%):  35
    Opt. T:  28-30℃
    Low T(℃):  13(neg)
    Mid T(℃):  40(neg)
    Opt. pH:  7.2-7.6
    pH 6.0-8.0:  6.8-7.8(+)
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  + Catalase:  + Esterase:  + Lipase:  d

    References

    SPECIFIC REFERENCES FOR LEPTOSPIRA INTERROGANS
  • Wolbach1914 - Notes on a filterable Spirochete from fresh Water. Spirocheta biflexa (new Species).
  • Noguchi1919 - Etiology of Yellow Fever: II. Transmission Experiments on Yellow Fever.
  • Inada1916 - The etiology, mode of infection, and specific therapy of Weil's Disease (Spirochaetosis icterohaemorrhagica).
  • Feresu1998 - A new leptospiral serovar, ngavi, in the Tarassovi serogroup isolated from Zimbabwe oxen.
  • Faine1982 - Amended Descriptions of the Genus Leptospira Noguchi 1917 and the Species L. interrogans (Stimson 1907) Wenyon 1926 and L. biflexa (Wolbach and Binger 1914) Noguchi 1918
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR LEPTOSPIRA INTERROGANS
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
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    • Added: January 14, 2022