Mageeibacillus indolicus

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Mageeibacillus indolicus is a Gram-variable, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 5 gut microbiome compilation studies or metastudies. The DNA G+C content is 44.2%. Mageeibacillus indolicus is probably a rare gut coloniser. (Austin2015)



  • This organism has been recovered from human faeces, vagina, and clinical sources. Could be a possible pathogen in humans, but unknown at this stage. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Austin2015);
    Character Response
  • 🌡
  • Temperature tolerance:
  • Grows optimally at 35-42℃.
  • Active enzymes:
  • acid phosphatase; Arg arylamidase; fucosidase; Gly arylamidase; His arylamidase; Leu arylamidase; Phe arylamidase; Ser arylamidase; Tyr arylamidase; Val arylamidase; naphthol-ASBI-P;
  • ±
  • Strain-dependent active enzymes:
  • Ala arylamidase;
    • SPECIAL FEATURES (Austin2015);
    Character Response
  • ✓
  • Metabolites produced:
  • indole;
    • RESPONSE TO ANTIBIOTICS (Austin2015);
    Class Active Resistant
  • Cephalosporins:
  • cefoxitin;
  • Heterocycles:
  • metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin;
  • colistin;

  • N/A

  • Strains are asaccharolytic but enzymatic activities are present for arginine arylamidase, phenylalanine arylamidase, leucine arylamidase, tyrosine arylamidase, glycine arylamidase, _-fucosidase, histidine arylamidase, serine arylamidase, valine arylamidase, acid phosphatase and napthol-AS-BI-phosphohydrolase. Susceptibility testing to metronidazole, clindamycin and cefoxitin was performed with no resistance observed, however only three isolates were tested, BAA-2120T and CCUG 59143T. [PMID: 25482717]

  • GutFeeling KnowledgeBase COMMENTS [Website]

    This strain was isolated from the human vaginal cavity. Clostridiales BVAB3 are associated with bacterial vaginosis; however it is not clear if this strain is a pathogen or not. It has been sequenced as part of the Human Microbiome Project (HMP), initiated to probe the richness of the microbial communities living in and on the human body in an effort to help us understand their role in human health and disease. [UP000008234] Cells are Gram positive but stain Gram negative ans are vancomycin sensitive, colistin resistant, non-motile, catalase, oxidase, urease, lipase and lecithinase negative, non-cellulolytic and are indole positive. Rods are approximately 1.25 _m in length and 588 nm in diameter occurring in chains or in small aggregates when grown as previously mentioned. Optimal temperature for growth is 37°C. [[PMID: 25482717]

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Hungateiclostridiaceae Genus:  Mageeibacillus Gram stain:  vr O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces, vagina, and clinical sources
    DNA G+C(%):  44.2
    Opt. T:  35-42℃
    		Aesculin:  neg Urea:  neg Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Fructose:  neg Galactose:  neg Glucose:  neg Cellubiose:  neg Lactose:  neg Maltose:  neg Sucrose:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg Urease:  neg α-Fucosidase:  + AlanineAA:  d ArgAA:  + GlyAA:  + HisAA:  + LeuAA:  + PheAA:  + SerAA:  + TyrAA:  + ValAA:  + AcidP:  + Lecithinase:  neg Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Indole:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    cefoxitin:  SensRNG: (4-8)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  RNG: (4-16)
    vancomycin:  Sens
    metronidazole:  SensRNG: (0.25-0.5)
    clindamycin:  S(0.125)
    colistin:  Res

    References

    SPECIFIC REFERENCES FOR MAGEEIBACILLUS INDOLICUS
  • Austin2015 - Mageeibacillus indolicus gen. nov., sp. nov.: A novel bacterium isolated from the female genital tract.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR MAGEEIBACILLUS INDOLICUS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • King2019 - Baseline human gut microbiota profile in healthy people and standard reporting template.
  • LeChatelier2013 - Richness of human gut microbiome correlates with metabolic markers
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • Qin2012 - Metagenome-wide association study of gut microbiota in type 2 diabetes
  • ...............................
    • GENERAL REFERENCES FOR MAGEEIBACILLUS INDOLICUS
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: February 08, 2021