Mannheimia haemolytica

(aka Pasteurella haemolytica)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Mannheimia haemolytica, (aka Pasteurella haemolytica), is a Gram-negative, non-spore-forming, facultatively anaerobic, non-motile, coccobacillus bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 43.6%. Mannheimia haemolytica is probably a rare gut coloniser. (Angen1999)



  • This organism has been recovered from cattle and sheep with pneumonia and septicaemia. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: human and animal pathogen). Is a known human pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Angen1999);
    Character Response
  • H+
  • Acid from carbohydrates usually produced:
  • glucose; xylose; maltose; mannitol; sorbitol;
  • ±
  • Strain-dependent acid from carbs:
  • inositol;
  • Active enzymes:
  • alkaline phosphatase; fucosidase; oxidase;
  • ±
  • Strain-dependent active enzymes:
  • β-galactosidase; xylosidase;
    • SPECIAL FEATURES (Angen1999);
    Character Response
  • ✗
  • Metabolites not produced:
  • indole;
  • Haemolysis:
  • beta
  • ✓
  • Nitrate:
  • reduced
    • RESPONSE TO ANTIBIOTICS
    Class Active Resistant
  • Quinolines:
  • garenoxacin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Proteobacteria Class:  Gammaproteobacteria Order:  Pasteurellales Family:  Pasteurellaceae Genus:  Mannheimia Alt. name:  Pasteurella haemolytica Gram stain:  neg O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Coccobacillus
    Health:  Unknown
    Source:  cattle and sheep with pneumonia and septicaemia
    DNA G+C(%):  43.6
    		Urea:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    L-Arabinose:  neg Glucose:  + Mannose:  neg Sorbose:  neg Xylose:  + Cellubiose:  neg Gentiobiose:  neg Maltose:  + Melibiose:  neg Trehalose:  neg Amygdalin:  neg Aesculin:  neg Adonitol:  neg Inositol:  d Mannitol:  + Sorbitol:  + Arbutin:  neg Salicin:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Citrate:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  + Urease:  neg α-Fucosidase:  + β-Galactosidase:  d β-Glucosidase:  neg Xylosidase:  d ArgDH:  neg OrnDC:  neg AlkalineP:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    penicillin_G:  Var(MIC50): 0.125, MIC90: >8, RNG: (0.06->8)
    garenoxacin:  S(MIC50): 0.015, MIC90: 0.06, RNG: (0.004–0.06)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  Var(MIC50): 0.5, MIC90: >8, RNG: (0.125–>8)

    References

    SPECIFIC REFERENCES FOR MANNHEIMIA HAEMOLYTICA
  • Angen1999 - Taxonomic relationships of the [Pasteurella] haemolytica complex as evaluated by DNA-DNA hybridizations and 16S rRNA sequencing with proposal of Mannheimia haemolytica gen. nov., comb. nov., Mannheimia granulomatis comb. nov., Mannheimia glucosida sp. nov., Mannheimia ruminalis sp. nov. and Mannheimia varigena sp. nov.
  • Davies1996 - Phylogenetic relationships and diversity within the Pasteurella haemolytica complex based on 16S rRNA sequence comparison and outer membrane protein and lipopolysaccharide analysis.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR MANNHEIMIA HAEMOLYTICA
  • De2020 - Metagenomic analysis of gut microbiome and resistome of diarrheal fecal samples from Kolkata, India, reveals the core and variable microbiota including signatures of microbial dark matter.
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    • Added: January 19, 2022