Massilia varians

(aka Naxibacter varians)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Massilia varians, (aka Naxibacter varians), is a Gram-negative, non-spore-forming, strictly aerobic, non-motile, rod-shaped bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. Massilia varians is likely to be transient and not a long-term gut coloniser. (Kampfer2011; Kampfer2008)



  • This organism has been recovered from human faeces and clinical sources (eye - CCUG). The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread (notes: opportunistic in immunocompromised patients). Is a rare opportunistic pathogen. Likely to be transient and not a long-term gut commensal.
    • QUIRKS
  • Obligate aerobe; unlikely to be a gut coloniser.
    • GENERAL CHARACTERISTICS (Kampfer2011); (Kampfer2008);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin;
  • ⥅
  • Substrates assimilated or utilised:
  • lactose; maltose; rhamnose; proline; serine; acetate; fumarate; 3-hydroxybutyrate; lactate; malate; propionate; pyruvate; oxoglutarate;
  • ±
  • Strain-dependent substrate utilisation:
  • L-arabinose; glucose;
  • Active enzymes:
  • alkaline phosphatase; β-galactosidase;
    • SPECIAL FEATURES
    Character Response
  • ✓
  • ONPG test:
  • active
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Kampfer2008);
    Class Active Resistant
  • Penicillins:
  • amoxicillin; amoxicillin-clavulanic acid; penicillin G;
  • Quinolines:
  • ciprofloxacin;
  • Aminoglycosides:
  • gentamicin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • trimethoprim;
  • Miscellaneous antibiotics:
  • colistin; polymyxin B;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Proteobacteria Class:  Betaproteobacteria Order:  Burkholderiales Family:  Oxalobacteraceae Genus:  Massilia Alt. name:  Naxibacter varians Gram stain:  neg O2 Relation.:  strictly aerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces and clinical sources (eye - CCUG)
    		Aesculin:  + Urea:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Glucose:  neg Cellubiose:  neg Maltose:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    L-Arabinose:  d(neg) Glucose:  d(neg) Mannose:  neg Rhamnose:  + Lactose:  + Maltose:  + Sucrose:  neg Trehalose:  neg Gluconate:  neg Mannitol:  neg His:  neg Pro:  + Ser:  + Acetate:  + Aconitate:  cis(neg) Adipate:  neg Citrate:  neg Fumarate:  + 3-Hydroxybutyrate:  + 3-Hydroxybenzoate:  neg 4-Hydroxybenzoate:  neg Lactate:  + Malate:  + Propionate:  + Pyruvate:  + Suberate:  neg Valerate:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Urease:  neg β-Galactosidase:  + AlkalineP:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  S(25; disc)
    Augmentin:  S(30; disc)
    penicillin_G:  S(10U)
    gentamicin:  S(10; disc)
    ciprofloxacin:  S(5; disc)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    rifampicin:  S(5; disc)
    trimethoprim:  S(5; disc)
    colistin:  S(25; disc)
    polymyxin_B:  S(300U)

    References

    SPECIFIC REFERENCES FOR MASSILIA VARIANS
  • Kampfer2011 - Revision of the genus Massilia La Scola et al. 2000, with an emended description of the genus and inclusion of all species of the genus Naxibacter as new combinations, and proposal of Massilia consociata sp. nov.
  • Kampfer2008 - Naxibacter varians sp. nov. and Naxibacter haematophilus sp. nov., and emended description of the genus Naxibacter.
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR MASSILIA VARIANS
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
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    • Added: December 15, 2021