Megasphaera micronuciformis

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Megasphaera micronuciformis is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, coccus bacterium. It has been detected in at least 8 gut microbiome compilation studies or metastudies. The DNA G+C content is 46.4%. Megasphaera micronuciformis is probably a common, although minor, coloniser of the gut. (Marchandin2003)



  • This organism has been recovered from clinical specimens. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread (notes: opportunistic in immunocompromised patients). Can cause opportunistic infections, particularly in immunocompromised people. A possible gut commensal.
    • GENERAL CHARACTERISTICS
    Character Response
    SPECIAL FEATURES (Marchandin2003);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; propionate; butyrate; valerate (minor); isobutyrate (trace); isovalerate;
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
  • ✗
  • Pigments:
  • not produced
    • RESPONSE TO ANTIBIOTICS (Marchandin2003);
    Class Active Resistant
  • Aminoglycosides:
  • kanamycin;
  • Heterocycles:
  • metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • colistin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Negativicutes Order:  Veillonellales Family:  Veillonellaceae Genus:  Megasphaera Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Coccus Pigment:  neg
    Health:  Unknown
    Source:  clinical specimens
    DNA G+C(%):  46.4
    		Aesculin:  neg Gelatin:  neg Milk:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg Fructose:  neg Galactose:  neg Glucose:  neg Mannose:  neg Rhamnose:  neg Ribose:  neg Xylose:  neg Cellubiose:  neg Lactose:  neg Maltose:  neg Melezitose:  neg Melibiose:  neg Sucrose:  neg Trehalose:  neg Aesculin:  neg Starch:  neg Glycerol:  neg Inositol:  neg Mannitol:  neg Sorbitol:  neg Salicin:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Propionate:  + Butyrate:  + Valerate:  minor(+) Isobutyrate:  trace(+) Isovalerate:  + Indole:  neg Pigment:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    kanamycin:  S(1000; disc)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    vancomycin:  S(5; disc)
    metronidazole:  S(4; disc)
    colistin:  S(10; disc)

    References

    SPECIFIC REFERENCES FOR MEGASPHAERA MICRONUCIFORMIS
  • Marchandin2003 - Phylogenetic analysis of some Sporomusa sub-branch members isolated from human clinical specimens: description of Megasphaera micronuciformis sp. nov.
  • Ishaq2017 - Molecular estimation of alteration in intestinal microbial composition in Hashimoto's thyroiditis patients
  • Lv2016 - Alterations and correlations of the gut microbiome, metabolism and immunity in patients with primary biliary cirrhosis
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR MEGASPHAERA MICRONUCIFORMIS
  • De2020 - Metagenomic analysis of gut microbiome and resistome of diarrheal fecal samples from Kolkata, India, reveals the core and variable microbiota including signatures of microbial dark matter.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jeong2021 - The effect of taxonomic classification by full-length 16S rRNA sequencing with a synthetic long-read technology
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • ...............................
    • Added: January 14, 2022