Mobiluncus curtisii

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Mobiluncus curtisii is a Gram-variable, non-spore-forming, anaerobic, motile, rod-shaped - curved bacterium. It has been detected in at least 6 gut microbiome compilation studies or metastudies. The DNA G+C content is 51-52%. Mobiluncus curtisii is probably a rare gut coloniser. (Hoyles2004; Spiegel1984)



  • This organism has been recovered from human faeces, and vagina. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. Pathogenicity status unknown, or very unlikely to be pathogenic. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Hoyles2004); (Spiegel1984);
    Character Response
  • Substrates hydrolysed or digested:
  • arginine; hippurate; starch;
  • H+
  • Acid from carbohydrates usually produced:
  • melibiose;
  • ⥅
  • Substrates assimilated or utilised:
  • arginine;
  • Active enzymes:
  • Ala-Phe-Pro arylamidase; α-galactosidase; β-galactosidase; α-glucosidase; Gly arylamidase; Leu-Gly arylamidase; phosphoamidase;
  • ±
  • Strain-dependent active enzymes:
  • esterase C4; esterase lipase C8;
    • SPECIAL FEATURES (Hoyles2004); (Spiegel1984);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; succinate (major); ammonia;
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • VP test:
  • not active
  • Nitrate:
  • reduction is variable
  • ✗
  • NO3➔NO2:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Spiegel1984);
    Class Active Resistant
  • Penicillins:
  • penicillin;
  • Quinolines:
  • nalidixic-acid;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • colistin;

  • Lagier, J.-C., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., Trape, J.-F., Koonin, E. V., La Scola, B., & Raoult, D. (2012). Microbial culturomics: paradigm shift in the human gut microbiome study. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(12), 1185–1193.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Actinomycetales Family:  Actinomycetaceae Genus:  Mobiluncus Gram stain:  vr O2 Relation.:  anaerobic Spore:  No spore Motility:  Swimming Morphology:  Rod - curved
    Health:  Unknown
    Source:  human faeces, and vagina
    DNA G+C(%):  51-52
    		Aesculin:  neg Urea:  neg Gelatin:  neg Starch:  + Arginine:  + Hippurate:  + Meat:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg L-Arabinose:  neg Fructose:  w(neg) Galactose:  vr Glucose:  w Mannose:  neg Rhamnose:  neg Ribose:  neg D-Tagatose:  neg Xylose:  w Cellubiose:  neg Lactose:  neg Maltose:  w Melezitose:  neg Melibiose:  + Sucrose:  neg Trehalose:  neg Amygdalin:  neg Dextrin:  neg Aesculin:  neg Glycogen:  w Inulin:  neg Starch:  neg Adonitol:  neg D-Arabitol:  neg Erythritol:  neg Inositol:  neg Mannitol:  neg Sorbitol:  neg Salicin:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Arg:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  d(+) β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg β-Mannosidase:  neg Chymotrypsin:  neg GluDC:  vr Trypsin:  neg AlanineAA:  vr AlaPheProAA:  + CystineAA:  neg GluGluAA:  neg GlyAA:  + LeuAA:  vr LeuGlyAA:  + PyrrolidAA:  neg ValAA:  neg AlkalineP:  neg AcidP:  neg Esterase(C4):  d(w) EstLip(C8):  d(w) Lipase:  neg Lipase(C14):  neg Phosphoamidase:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Succinate:  Major(+) Ammonia:  + Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    penicillin:  Sens
    nalidixic-acid:  Res
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    vancomycin:  Sens
    colistin:  Res

    References

    SPECIFIC REFERENCES FOR MOBILUNCUS CURTISII
  • Hoyles2004 - Transfer of Members of the Genus Falcivibrio to the Genus Mobiluncus, and Emended Description of the Genus Mobiluncus.
  • Spiegel1984 - Mobiluncus gen. nov., Mobiluncus curtisii subsp. curtisii sp. nov., Mobiluncus curtisii subsp. holmesii subsp. nov., and Mobiluncus mulieris sp. nov., Curved Rods from the Human Vagina.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR MOBILUNCUS CURTISII
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • McLaughlin2010 - The bacteriology of pouchitis: a molecular phylogenetic analysis using 16S rRNA gene cloning and sequencing.
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
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    • Added: April 08, 2021