Mogibacterium neglectum

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Mogibacterium neglectum is a Gram-positive, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 3 gut microbiome compilation studies or metastudies. The DNA G+C content is 41-42%. Mogibacterium neglectum is probably a rare gut coloniser. (Nakazawa2002; Editorial2011bBergey)



  • This organism has been recovered from dental disease and human faeces. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. Known to cause illness. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Nakazawa2002); (Editorial2011bBergey);
    Character Response
    SPECIAL FEATURES (Nakazawa2002); (Editorial2011bBergey);
    Character Response
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Haemolysis:
  • absent
    • RESPONSE TO ANTIBIOTICS (Goldstein2013);
    Class Active Resistant
  • Penicillins:
  • imipenem; piperacillin-tazobactam;
  • Quinolines:
  • moxifloxacin;
  • Heterocycles:
  • metronidazole;

  • Bik, E. M., Eckburg, P. B., Gill, S. R., Nelson, K. E., Purdom, E. A., Francois, F., Perez-Perez, G., Blaser, M. J., & Relman, D. A. (2006). Molecular analysis of the bacterial microbiota in the human stomach. Proceedings of the National Academy of Sciences of the United States of America, 103(3), 732–737.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Mogibacteriaceae Genus:  Mogibacterium Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  dental disease and human faeces
    DNA G+C(%):  41-42
    		Urea:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Arabinose:  neg Fructose:  neg Galactose:  neg Glucose:  neg Mannose:  neg Rhamnose:  neg Ribose:  neg Xylose:  neg Cellubiose:  neg Lactose:  neg Maltose:  neg Melezitose:  neg Melibiose:  neg Sucrose:  neg Trehalose:  neg Adonitol:  neg Amygdalin:  neg Erythritol:  neg Aesculin:  neg Glycogen:  neg Inositol:  neg Mannitol:  neg Salicin:  neg Sorbitol:  neg Starch:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    piper-taz:  S(MIC50): 0.25, MIC90: 1, RNG: (0.015–1)
    imipenem:  S(MIC50): 0.06, MIC90: 0.25, RNG: (0.015–0.5)
    moxifloxacin:  S(MIC50): 0.5, MIC90: 1, RNG: (0.06–8)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    metronidazole:  S(MIC50): 0.5, MIC90: 2, RNG: (0.125–4)

    References

    SPECIFIC REFERENCES FOR MOGIBACTERIUM NEGLECTUM
  • Nakazawa2002 - Taxonomic characterization of Mogibacterium diversum sp. nov. and Mogibacterium neglectum sp. nov., isolated from human oral cavities.
  • Editorial2011bBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Clostridiales, Family XIII. Incertae Sedis, Genus II. Mogibacterium
  • Goldstein2013 - In vitro activity of Biapenem plus RPX7009, a carbapenem combined with a serine β-lactamase inhibitor, against anaerobic bacteria.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR MOGIBACTERIUM NEGLECTUM
  • Bik2006 - Molecular analysis of the bacterial microbiota in the human stomach.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Wang2005 - Comparison of bacterial diversity along the human intestinal tract by direct cloning and sequencing of 16S rRNA genes.
  • ...............................
    • GENERAL REFERENCES FOR MOGIBACTERIUM NEGLECTUM
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: April 08, 2021