Moryella indoligenes

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Moryella indoligenes is a Gram-positive, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 3 gut microbiome compilation studies or metastudies. The DNA G+C content is 50.2%. Moryella indoligenes is probably a rare gut coloniser. (Carlier2007; Carlier2011bBergey)



  • This organism has been recovered from human faeces, human gut, and clinical sources (abscesses). The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. Can cause opportunistic infections, particularly in immunocompromised people. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (Carlier2007); (Carlier2011bBergey);
    Character Response
    SPECIAL FEATURES (Carlier2007); (Carlier2011bBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; butyrate; lactate (minor); indole;
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Carlier2007); (Carlier2011bBergey);
    Class Active Resistant
  • Penicillins:
  • amoxicillin; ampicillin; imipenem; penicillin G;
  • Cephalosporins:
  • cefotaxime; cefoxitin; cephalothin;
  • Macrolides:
  • erythromycin;
  • Tetracyclines:
  • tetracycline;
  • Aminoglycosides:
  • kanamycin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • metronidazole;
  • trimethoprim-sulfamethoxazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • bile; colistin;

  • Lagier, J.-C., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., Trape, J.-F., Koonin, E. V., La Scola, B., & Raoult, D. (2012). Microbial culturomics: paradigm shift in the human gut microbiome study. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(12), 1185–1193.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Lachnospiraceae Genus:  Moryella Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces, human gut, and clinical sources (abscesses)
    DNA G+C(%):  50.2
    		Aesculin:  neg Urea:  neg Gelatin:  neg Milk:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg Fructose:  neg Galactose:  vr Glucose:  vr Mannose:  neg Rhamnose:  neg Ribose:  vr L-Xylose:  neg Cellubiose:  neg Lactose:  neg Maltose:  vr Melezitose:  neg Melibiose:  neg Sucrose:  neg Trehalose:  neg Aesculin:  neg Starch:  neg Glycerol:  neg Inositol:  neg Mannitol:  neg Sorbitol:  neg Salicin:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg ArgDH:  neg GluDC:  neg AlanineAA:  neg GluGluAA:  neg GlyAA:  neg LeuAA:  neg LeuGlyAA:  neg PyrrolidAA:  neg AlkalineP:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Butyrate:  + Lactate:  minor(+) Indole:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  Sens
    ampicillin:  Sens
    penicillin_G:  Sens
    imipenem:  Sens
    cefotaxime:  Sens
    cefoxitin:  Sens
    cephalothin:  Sens
    kanamycin:  S(1000; disc)
    erythromycin:  Res
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  R(vr)
    vancomycin:  S(5; disc)
    rifampicin:  Res
    metronidazole:  S(4; disc)
    SXT:  Res
    colistin:  S(10; disc)
    Bile:  Sens

    References

    SPECIFIC REFERENCES FOR MORYELLA INDOLIGENES
  • Carlier2007 - Moryella indoligenes gen. nov., sp. nov., an anaerobic bacterium isolated from clinical specimens.
  • Carlier2011bBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Lachnospiraceae, Genus XII. Moryella
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR MORYELLA INDOLIGENES
  • PerezBrocal2015 - Metagenomic Analysis of Crohn's Disease Patients Identifies Changes in the Virome and Microbiome Related to Disease Status and Therapy, and Detects Potential Interactions and Biomarkers
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • ...............................
    • GENERAL REFERENCES FOR MORYELLA INDOLIGENES
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: April 08, 2021