Mycolicibacterium aubagnense

(aka Mycobacterium aubagnense)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Mycolicibacterium aubagnense, (aka Mycobacterium aubagnense), is a Gram-positive, non-spore-forming, aerobic, non-motile, rod-shaped bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 65%. Mycolicibacterium aubagnense is unlikely to be a gut coloniser. (Adekambi2006)



  • This organism has been recovered from human faeces and bronchial aspirate. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. Is a rare opportunistic pathogen. Likely to be transient and not a long-term gut commensal.
    • GENERAL CHARACTERISTICS (Adekambi2006);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin;
  • 🧂
  • Salt tolerance:
  • doesn't tolerate 5% salt;
  • 🌡
  • Temperature tolerance:
  • grows at 24℃; grows at 37℃; doesn't grow at 42℃; Grows optimally at 30℃.
  • Active enzymes:
  • alkaline phosphatase; catalase;
  • ±
  • Strain-dependent active enzymes:
  • pyrrolidine arylamidase;
    • SPECIAL FEATURES (Adekambi2006);
    Character Response
  • ✗
  • Metabolites not produced:
  • Hâ‚‚S; indole;
  • ✓
  • VP test:
  • active
  • ✗
  • Nitrate:
  • not reduced
  • ✗
  • Pigments:
  • not produced
    • RESPONSE TO ANTIBIOTICS (Adekambi2006);
    Class Active Resistant
  • Penicillins:
  • amoxicillin; amoxicillin-clavulanic acid; imipenem;
  • penicillin;
  • Cephalosporins:
  • cefoxitin;
  • cefotaxime; cephalothin;
  • Macrolides:
  • azithromycin; clarithromycin; erythromycin;
  • Tetracyclines:
  • doxycycline; minocycline;
  • Quinolines:
  • ciprofloxacin; ofloxacin; sparfloxacin;
  • pipemidic-acid;
  • Aminoglycosides:
  • amikacin; tobramycin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • trimethoprim-sulfamethoxazole;
  • metronidazole;
  • Vancomycins:
  • vancomycin; teicoplanin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Corynebacteriales Family:  Mycobacteriaceae Genus:  Mycolicibacterium Alt. name:  Mycobacterium aubagnense Gram stain:  + O2 Relation.:  aerobic Spore:  No spore Motility:  Sessile Morphology:  Rod Pigment:  neg
    Health:  Unknown
    Source:  human faeces and bronchial aspirate
    DNA G+C(%):  65
    Opt. T:  30℃
    Lower T(℃):  24(+)
    Mid T(℃):  37(+)
    High T(℃):  42(neg)
    NaCl 3-5%:  5(neg)
    		Aesculin:  + Urea:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Glucose:  neg Ribose:  neg Xylose:  neg Lactose:  neg Maltose:  neg Sucrose:  neg Glycogen:  neg Mannitol:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    L-Arabinose:  neg Glucose:  neg Rhamnose:  neg Melibiose:  neg Sucrose:  neg Amygdalin:  neg Inositol:  neg Mannitol:  neg Sorbitol:  neg Citrate:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  + Urease:  neg Ac-β-glcamnd:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucuronidase:  neg ArgDH:  neg LysDC:  neg OrnDC:  neg TrpAA:  neg PyrrolidAA:  d AlkalineP:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		H2S:  neg Indole:  neg Pigment:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  S(0.125)
    Augmentin:  S(<4; disc)
    penicillin:  R(>32)
    imipenem:  S(0.75)
    cefotaxime:  R(64)
    cefoxitin:  S(<8)
    cephalothin:  R(30; disc)
    amikacin:  S(3)
    tobramycin:  S(<4)
    azithromycin:  S(2)
    erythromycin:  S(1)
    clarithromycin:  S(0.125)
    ciprofloxacin:  S(0.125)
    ofloxacin:  S(0.25)
    pipemidic_acid:  R(>16)
    sparfloxacin:  S(0.125)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(1)
    minocycline:  S(1.5)
    teicoplanin:  R(64)
    vancomycin:  R(>256)
    rifampicin:  R(>32)
    metronidazole:  R(256)
    SXT:  S(<2)
    colistin:  Var(MIC50): >2), MIC90: Var(>2

    References

    SPECIFIC REFERENCES FOR MYCOLICIBACTERIUM AUBAGNENSE
  • Gupta2018 - Phylogenomics and Comparative Genomic Studies Robustly Support Division of the Genus Mycobacterium into an Emended Genus Mycobacterium and Four Novel Genera.
  • Adekambi2006 - rpoB gene sequence-based characterization of emerging non-tuberculous mycobacteria with descriptions of Mycobacterium bolletii sp. nov., Mycobacterium phocaicum sp. nov. and Mycobacterium aubagnense sp. nov.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR MYCOLICIBACTERIUM AUBAGNENSE
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • ...............................
    • Added: December 15, 2021