Neisseria perflava

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Neisseria perflava is a Gram-negative, non-spore-forming, aerobic, non-motile, diplococci bacterium. It has been detected in at least 4 gut microbiome compilation studies or metastudies. Neisseria perflava is probably a rare gut coloniser. (Barrett1994)



  • This organism has been recovered from human faeces and clinical sources (blood, wound, sputum - CCUG). The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread (notes: opportunistic in immunocompromised patients). It is an opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Barrett1994);
    Character Response
  • ±
  • Strain-dependent hydrolysis or digestion:
  • starch;
  • 🌡
  • Temperature tolerance:
  • Grows optimally at 35-37℃.
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; glucose; maltose; sucrose;
  • Active enzymes:
  • Ala arylamidase; carbonic anhydrase; catalase; Gly arylamidase; oxidase; Pro arylamidase; Ser arylamidase;
  • ±
  • Strain-dependent active enzymes:
  • acid phosphatase;
    • SPECIAL FEATURES (Barrett1994);
    Character Response
  • ✗
  • Metabolites not produced:
  • indole;
  • ✓
  • Haemolysis:
  • present
  • ✗
  • Nitrate:
  • not reduced
  • ✓
  • Nitrite:
  • reduced
  • ✗
  • Pigments:
  • not produced
    • RESPONSE TO ANTIBIOTICS
    Class Active Resistant
  • Quinolines:
  • ofloxacin; sparfloxacin;
  • Miscellaneous antibiotics:
  • colistin;

  • Lagier, J.-C., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., Trape, J.-F., Koonin, E. V., La Scola, B., & Raoult, D. (2012). Microbial culturomics: paradigm shift in the human gut microbiome study. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(12), 1185–1193.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Proteobacteria Class:  Betaproteobacteria Order:  Neisseriales Family:  Neisseriaceae Genus:  Neisseria Gram stain:  neg O2 Relation.:  aerobic Spore:  No spore Motility:  Sessile Morphology:  Diplococci Pigment:  neg
    Health:  Unknown
    Source:  human faeces and clinical sources (blood, wound, sputum - CCUG)
    Opt. T:  35-37℃
    		Urea:  neg Gelatin:  neg Starch:  d(neg) DNA:  neg Tween:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    D-Arabinose:  neg L-Arabinose:  neg Fructose:  + Fucose:  neg D-Fucose:  neg Galactose:  neg Glucose:  + Mannose:  neg D-Lyxose:  neg Rhamnose:  neg Ribose:  neg Sorbose:  neg L-Sorbose:  neg D-Tagatose:  neg Xylose:  neg L-Xylose:  neg Cellubiose:  neg Gentiobiose:  neg Lactose:  neg Maltose:  + Melezitose:  neg Melibiose:  neg Sucrose:  + Trehalose:  neg Turanose:  neg Amygdalin:  neg Dextrin:  neg Aesculin:  neg Glycogen:  neg Inulin:  neg Starch:  neg Adonitol:  neg D-Arabitol:  neg L-Arabitol:  neg Dulcitol:  neg Erythritol:  neg Glycerol:  neg Inositol:  neg Mannitol:  neg Sorbitol:  neg Xylitol:  neg Arbutin:  neg Gluconate:  neg 2-Ketogluconate:  neg 5-Ketogluconate:  neg Me-α-D-Glc:  neg Me-α-D-Mann:  neg Me-Xyloside:  neg NAc-α-GA:  neg Salicin:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  + Catalase:  + Urease:  neg Carbonic anh.:  + α-Arab:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg Chymotrypsin:  neg γ-Glu transf.:  neg OrnDC:  neg Phe deaminase:  neg Trypsin:  neg AlanineAA:  + AlaPheProAA:  neg CystineAA:  neg GluGluAA:  neg GlyTrpAA:  neg GlyAA:  + HisAA:  neg LeuAA:  neg ProAA:  + PheAA:  neg PyrogluAA:  neg SerAA:  + TyrAA:  neg ValAA:  neg AlkalineP:  neg AcidP:  d DNAse:  neg Esterase(C4):  neg EstLip(C8):  neg Lipase:  neg Lipase(C14):  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Indole:  neg Pigment:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    clarithromycin:  Var(MIC50): 4, MIC90: 8, RNG: (0.25-16)
    ofloxacin:  S(MIC50): 0.06, MIC90: 0.12, RNG: (0.015-0.12)
    sparfloxacin:  S(MIC50): 0.007, MIC90: 0.03, RNG: (<0.003-0.03)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    colistin:  Sens

    References

    SPECIFIC REFERENCES FOR NEISSERIA PERFLAVA
  • Barrett1994 - A numerical phenotypic taxonomic study of the genus Neisseria.
  • Finegold2002 - Gastrointestinal microflora studies in late-onset autism
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR NEISSERIA PERFLAVA
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Pfleiderer2013 - Culturomics identified 11 new bacterial species from a single anorexia nervosa stool sample.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • ...............................
    • Added: April 08, 2021