Oribacterium sinus

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Oribacterium sinus is a Gram-variable, non-spore-forming, strictly anaerobic, motile, oval-shaped bacterium. It has been detected in at least 8 gut microbiome compilation studies or metastudies. The DNA G+C content is 42.4%. Oribacterium sinus is probably a common, although minor, coloniser of the gut. (Carlier2004; Carlier2011cBergey)



  • This organism has been recovered from human faeces, and oral cavity (sinus). The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread (notes: opportunistic in immunocompromised patients). Can cause opportunistic infections, particularly in immunocompromised people. Likely to be transient and not a long-term gut commensal.
    • GENERAL CHARACTERISTICS (Carlier2004); (Carlier2011cBergey);
    Character Response
  • H+
  • Acid from carbohydrates usually produced:
  • galactose; glucose; raffinose; sucrose;
  • Active enzymes:
  • Ala arylamidase; Arg arylamidase; α-galactosidase; β-galactosidase; α-glucosidase; Gly arylamidase; Leu arylamidase; Leu-Gly arylamidase; Pro arylamidase; Ser arylamidase;
    • SPECIAL FEATURES (Carlier2004); (Carlier2011cBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; lactate (major); indole;
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
  • ✗
  • Pigments:
  • not produced
    • RESPONSE TO ANTIBIOTICS (Carlier2004); (Carlier2011cBergey);
    Class Active Resistant
  • Penicillins:
  • amoxicillin; ampicillin; imipenem; mezlocillin; penicillin G; ticarcillin;
  • Cephalosporins:
  • cefotaxime; cefoxitin; cephalothin;
  • Macrolides:
  • erythromycin;
  • Tetracyclines:
  • tetracycline;
  • Aminoglycosides:
  • kanamycin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • chloramphenicol; metronidazole;
  • trimethoprim-sulfamethoxazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin;
  • colistin;

  • Lagier, J.-C., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., Trape, J.-F., Koonin, E. V., La Scola, B., & Raoult, D. (2012). Microbial culturomics: paradigm shift in the human gut microbiome study. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(12), 1185–1193.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Lachnospiraceae Genus:  Oribacterium Gram stain:  vr O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Swimming Morphology:  Oval-shaped Pigment:  neg
    Health:  Unknown
    Source:  human faeces, and oral cavity (sinus)
    DNA G+C(%):  42.4
    		Aesculin:  neg Urea:  neg Gelatin:  neg Milk:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg Fructose:  neg Galactose:  + Glucose:  + Mannose:  neg Rhamnose:  neg Ribose:  neg Xylose:  neg Cellubiose:  neg Lactose:  neg Maltose:  neg Melezitose:  neg Melibiose:  neg Sucrose:  + Trehalose:  neg Aesculin:  neg Starch:  neg Glycerol:  neg Inositol:  neg Sorbitol:  neg Salicin:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  neg β-Glucuronidase:  neg ArgDH:  neg GluDC:  neg AlanineAA:  + ArgAA:  + GluGluAA:  neg GlyAA:  + LeuAA:  + LeuGlyAA:  + ProAA:  + PyrrolidAA:  neg SerAA:  + AlkalineP:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Lactate:  Major(+) Indole:  + Pigment:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  Sens
    ampicillin:  Sens
    mezlocillin:  Sens
    penicillin_G:  Sens
    ticarcillin:  Sens
    imipenem:  Sens
    cefotaxime:  Sens
    cefoxitin:  Sens
    cephalothin:  Sens
    kanamycin:  R(1000; disc)
    erythromycin:  Res
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  R(vr)
    vancomycin:  S(5; disc)
    rifampicin:  Sens
    chloramphenicol:  Sens
    metronidazole:  S(4; disc)
    SXT:  Res
    clindamycin:  Sens
    colistin:  R(10; disc)

    References

    SPECIFIC REFERENCES FOR ORIBACTERIUM SINUS
  • Carlier2004 - Oribacterium sinus gen. nov., sp. nov., within the family 'Lachnospiraceae' (phylum Firmicutes).
  • Carlier2011cBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Lachnospiraceae, Genus XIII. Oribacterium
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR ORIBACTERIUM SINUS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Walker2011 - High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • ...............................
    • GENERAL REFERENCES FOR ORIBACTERIUM SINUS
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: April 08, 2021