Oscillibacter valericigenes

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Oscillibacter valericigenes is a Gram-negative, non-spore-forming, strictly anaerobic, motile, rod-shaped bacterium. It has been detected in at least 8 gut microbiome compilation studies or metastudies. The DNA G+C content is 52.9%. Oscillibacter valericigenes is probably a common, although minor, coloniser of the gut. (Iino2007; LeRoy2020)



  • This organism has been recovered from human faeces, and clam gut. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal.
    • QUIRKS
  • Homoacetogen.
    • GENERAL CHARACTERISTICS (Iino2007); (LeRoy2020);
    Character Response
  • 🧂
  • Salt tolerance:
  • tolerates 2.0% salt; grows weakly in 4% salt; Grows optimally with 0% salt.
  • pH
  • Acidity tolerance:
  • tolerates pH 5.5; tolerates pH 8.5; Grows optimally at pH 6.0-6.5.
  • 🌡
  • Temperature tolerance:
  • grows at 15℃; grows at 35℃; Grows optimally at 30℃.
  • H+
  • Acid from carbohydrates usually produced:
  • L-arabinose; glucose; ribose; xylose;
    • SPECIAL FEATURES (Iino2007); (LeRoy2020);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; valerate (major);
  • ✗
  • Nitrate:
  • not reduced
  • ✗
  • Nitrite:
  • not reduced
  • ✗
  • Sulfate:
  • not reduced
  • ✗
  • Thiosulfate:
  • not reduced

  • N/A

  • The strain grows fermentatively and produces acids from D-glucose, L-arabinose, D-ribose and D-xylose, with n-valeric acid being the major end product from glucose. Consistent with these observations, genes encoding catabolic enzymes and possible transporters for these sugars could be assigned on the genome. [PMID: 23408234]

  • GutFeeling KnowledgeBase COMMENTS [Website]

    Oscillibacter valericigenes represents a distinct phylogenetic lineage in clostridial cluster IV of the low-G+C-content Gram-positive bacteria. Strain Sjm 18-20, which is the type strain, was isolated from from alimentary canal material from Japanese corbicula clams (Corbicula japonica) collected on the sea coast in Shimane, Japan. The bacterium is strictly anaerobic, mesophilic, neutrophilic, Gram-negative staining, non-sporulating and motile by peritrichous flagella. Cells form straight to slightly curved rods 0.5 - 2.5 up to 6.0 um and often form very elongated rods (30 um) after prolonged cultivation. Optimal growth occurs at 30 degrees Celsius, pH 6.0-6.5, at < 4% NaCl. Acids are produced from D-glucose, L-arabinose, D-ribose and D-xylose, with valeric acid as the major end product from glucose (adapted from PMID 17684268), [UP000005219]

  • Lagier, J.-C., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., Trape, J.-F., Koonin, E. V., La Scola, B., & Raoult, D. (2012). Microbial culturomics: paradigm shift in the human gut microbiome study. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(12), 1185–1193.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Oscillospiraceae Genus:  Oscillibacter Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Swimming Morphology:  Rod
    Health:  Unknown
    Source:  human faeces, and clam gut
    DNA G+C(%):  52.9
    Opt. T:  30℃
    Low T(℃):  15(+)
    Mid T(℃):  35(+)
    NaCl 0.5-2%:  2.0(+)
    NaCl 3-5%:  4(w)
    Opt. pH:  6.0-6.5
    pH 4.2-5.9:  5.5(+)
    pH >8:  8.5(+)
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    D-Arabinose:  neg L-Arabinose:  + Fructose:  neg Galactose:  neg Glucose:  + Mannose:  neg Rhamnose:  neg Ribose:  + Sorbose:  neg Xylose:  + Cellubiose:  neg Lactose:  neg Maltose:  neg Melezitose:  neg Melibiose:  neg Sucrose:  neg Trehalose:  neg Starch:  neg Inositol:  neg Mannitol:  neg Sorbitol:  neg Gluconate:  neg Salicin:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg

    References

    SPECIFIC REFERENCES FOR OSCILLIBACTER VALERICIGENES
  • Iino2007 - Oscillibacter valericigenes gen. nov., sp. nov., a valerate-producing anaerobic bacterium isolated from the alimentary canal of a Japanese corbicula clam.
  • LeRoy2020 - Dysosmobacter welbionis gen. nov., sp. nov., isolated from human faeces and emended description of the genus Oscillibacter.
  • Coretti2018 - Gut Microbiota Features in Young Children With Autism Spectrum Disorders
  • Ying2020 - Gut microbiota and Chinese medicine syndrome: altered fecal microbiotas in spleen (Pi)-deficient patients
  • Luna2016 - Distinct Microbiome-Neuroimmune Signatures Correlate With Functional Abdominal Pain in Children With Autism Spectrum Disorder.
  • Mondot2011 - Highlighting new phylogenetic specificities of Crohn's disease microbiota.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR OSCILLIBACTER VALERICIGENES
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chung2019 - Impact of carbohydrate substrate complexity on the diversity of the human colonic microbiota.
  • Karlsson2013 - Gut metagenome in European women with normal, impaired and diabetic glucose control
  • King2019 - Baseline human gut microbiota profile in healthy people and standard reporting template.
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • Qin2012 - Metagenome-wide association study of gut microbiota in type 2 diabetes
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • ...............................
    • GENERAL REFERENCES FOR OSCILLIBACTER VALERICIGENES
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: February 08, 2021