Parabacteroides gordonii

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Parabacteroides gordonii is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 9 gut microbiome compilation studies or metastudies. The DNA G+C content is 44.6%. Parabacteroides gordonii is probably a common, although minor, coloniser of the gut. (Sakamoto2009a)



  • This organism has been recovered from human faeces, and clinical sources (wound, blood - CCUG). Could be a possible pathogen in humans, but unknown at this stage. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Sakamoto2009a);
    Character Response
  • 💧
  • Bile tolerance:
  • Resistant to 20% bile
  • H+
  • Acid from carbohydrates usually produced:
  • arabinose; L-arabinose; glucose; mannose; xylose; lactose; maltose; raffinose; sucrose;
  • Active enzymes:
  • Ala arylamidase; alkaline phosphatase; Arg arylamidase; N-Ac α-glucosaminidase; N-Ac β-glucosaminidase; α-galactosidase; β-galactosidase; α-glucosidase; Leu arylamidase; Leu-Gly arylamidase; pyrrolidine arylamidase;
    • SPECIAL FEATURES (Sakamoto2009a);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; succinate (minor);
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Nitrate:
  • not reduced
  • Bacteroides and Parabacteroides species are components of the colon resident microbiota, and both genera belong to the order Bacteroidales. Species of these genera are often associated with opportunistic mixed infections, such as intra-abdominal, obstetric-gynecologic and diabetic foot infections. In addition, these microorganisms are able to develop resistance to several antimicrobial drugs. Although antibiotics with good activity against these bacteria are currently available, high frequencies of resistance to some antimicrobials have been reported in several countries. Bacteroides and Parabacteroides species produce endogenous �_-lactamases, the most important mechanism of resistance to �_-lactam antibiotics. [PMID: 21655744]
  • GutFeeling KnowledgeBase COMMENTS [Website] Bacteroides and Parabacteroides species are components of the colon resident microbiota, and both genera belong to the order Bacteroidales. [PMID: 21655744] Cells are Gram-negative, obligately anaerobic, non-spore-forming, non-motile and rod-shaped, and 0.8-1.6μm in size. Major end-products are acetic and succinic acids. [PMID: 16825636]

  • Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006). Microbial ecology: human gut microbes associated with obesity. Nature, 444(7122), 1022–1023.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Bacteroidetes Class:  Bacteroidia Order:  Bacteroidales Family:  Tannerellaceae Genus:  Parabacteroides Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces, and clinical sources (wound, blood - CCUG)
    DNA G+C(%):  44.6
    Bile reaction(%):  20(+)
    		Aesculin:  neg Urea:  neg Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  + L-Arabinose:  + Glucose:  + Mannose:  + Rhamnose:  neg Xylose:  + Cellubiose:  neg Lactose:  + Maltose:  + Melezitose:  neg Sucrose:  + Trehalose:  neg Glycerol:  neg Mannitol:  neg Sorbitol:  neg Salicin:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  vr Urease:  neg G6PDH6PGDH:  neg Ac-α-glcamnd:  + Ac-β-glcamnd:  + α-Fucosidase:  neg α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  neg β-Glucuronidase:  neg ArgDH:  neg GluDC:  neg AlanineAA:  + ArgAA:  + GluGluAA:  neg GlyAA:  neg HisAA:  neg LeuAA:  + LeuGlyAA:  + ProAA:  neg PyrrolidAA:  + PheAA:  neg PyrogluAA:  neg SerAA:  neg TyrAA:  neg AlkalineP:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Succinate:  minor(+) Indole:  neg

    References

    SPECIFIC REFERENCES FOR PARABACTEROIDES GORDONII
  • Sakamoto2009a - Parabacteroides gordonii sp. nov., isolated from human blood cultures.
  • Huang2019 - Analysis of microbiota in elderly patients with Acute Cerebral Infarction
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR PARABACTEROIDES GORDONII
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Li2019b - Disordered intestinal microbes are associated with the activity of Systemic Lupus Erythematosus
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • PerezBrocal2015 - Metagenomic Analysis of Crohn's Disease Patients Identifies Changes in the Virome and Microbiome Related to Disease Status and Therapy, and Detects Potential Interactions and Biomarkers
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
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    • Added: April 08, 2021