Parasutterella excrementihominis

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Parasutterella excrementihominis is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, coccobacillus bacterium. It has been detected in at least 20 gut microbiome compilation studies or metastudies. The DNA G+C content is 49.8%. Parasutterella excrementihominis is a common gut coloniser. (Nagai2009)



  • This organism has been recovered from human faeces (CCUG). Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (Nagai2009);
    Character Response
  • 💧
  • Bile tolerance:
  • Grows in the presence of bile
  • Active enzymes:
  • Arg arylamidase; esterase C4; Leu arylamidase;
    • SPECIAL FEATURES
    Character Response
  • ✗
  • Nitrate:
  • not reduced

  • Parasutterella is still a relatively new genus and has been exclusively published in regards to literature on the intestinal microbiome (with the exception of the first two taxonomical papers on the discovery of P. excrementihominis and P. secunda). Both P. excrementihominis and P. secunda were isolated from fecal samples from healthy Japanese individuals and have been found to be part of the intestinal microbiome in the United States.[1][2] In a study that examined the effect of introducing and reversing diet-induced obesity on the gut microbiome and metabolism in mice, Parasutterella was decreased in mice with diet-induced obesity and increased in controls and reversal of the high fat diet with a healthier alternative (normal chow).[5] Other studies have shown increases of Parasutterella with sugar[6] and alcohol consumption.[7] Additional microbiome studies have associated increased abundance of Parasutterella with dysbiosis, or a lack of diversity in the microbial composition typically in the gut.[8][9] (Dysbiosis has been correlated with intestinal and metabolic dysfunction and several diseases, including inflammatory bowel diseases and obesity.)[10] For example, Parasutterella was increased in the submucosa in the ileum of the small intestine in individuals with Crohn's disease[8] and hypertriglyceridemia-related acute necrotizing pancreatitis in rats.[9] More research is needed to further explore the role of Parasutterella species as a part of the healthy gut microbiome and in microbial dysbiosis.

    https://en.wikipedia.org/wiki/Parasutterella

  • Nagai, F., Morotomi, M., Sakon, H., & Tanaka, R. (2009). Parasutterella excrementihominis gen. nov., sp. nov., a member of the family Alcaligenaceae isolated from human faeces. International Journal of Systematic and Evolutionary Microbiology, 59(Pt 7), 1793–1797.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Proteobacteria Class:  Betaproteobacteria Order:  Burkholderiales Family:  Sutterellaceae Genus:  Parasutterella Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Coccobacillus
    Health:  Unknown
    Source:  human faeces (CCUG)
    DNA G+C(%):  49.8
    Bile reaction(%):  +
    		Aesculin:  neg Urea:  neg Gelatin:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg Urease:  neg α-Arab:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg ArgDH:  neg Chymotrypsin:  neg GluDC:  neg Trypsin:  neg AlanineAA:  w ArgAA:  + CystineAA:  neg GluGluAA:  neg GlyAA:  w HisAA:  neg LeuAA:  + LeuGlyAA:  neg ProAA:  neg PheAA:  neg PyrogluAA:  neg SerAA:  neg TyrAA:  neg ValAA:  neg AlkalineP:  w AcidP:  w Esterase(C4):  + EstLip(C8):  w Lipase:  neg

    References

    SPECIFIC REFERENCES FOR PARASUTTERELLA EXCREMENTIHOMINIS
  • Nagai2009 - Parasutterella excrementihominis gen. nov., sp. nov., a member of the family Alcaligenaceae isolated from human faeces.
  • DeAngelis2013 - Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified
  • Giongo2011 - Toward defining the autoimmune microbiome for type 1 diabetes
  • Kim2020a - Altered Gut Microbiome Profile in Patients With Pulmonary Arterial Hypertension
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR PARASUTTERELLA EXCREMENTIHOMINIS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • De2020 - Metagenomic analysis of gut microbiome and resistome of diarrheal fecal samples from Kolkata, India, reveals the core and variable microbiota including signatures of microbial dark matter.
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • Nielsen2014 - MetaHIT Consortium. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Rothschild2018 - Environment dominates over host genetics in shaping human gut microbiota.
  • Tyakht2013 - Human gut microbiota community structures in urban and rural populations in Russia.
  • Urban2020 - Altered Fecal Microbiome Years after Traumatic Brain Injury
  • Wang2018 - A metagenome-wide association study of gut microbiota in asthma in UK adults
  • Wang2018a - Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model.
  • Wang2020a - Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • ...............................
    • GENERAL REFERENCES FOR PARASUTTERELLA EXCREMENTIHOMINIS
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
    • Added: April 08, 2021