Parasutterella secunda

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Parasutterella secunda is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, coccobacillus bacterium. It has been detected in at least 4 gut microbiome compilation studies or metastudies. The DNA G+C content is 48.2%. Parasutterella secunda is probably a rare gut coloniser. (Morotomi2011)



  • This organism has been recovered from human faeces. Pathogenicity status unknown, or very unlikely to be pathogenic. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Morotomi2011);
    Character Response
  • Active enzymes:
  • alkaline phosphatase; arginine dihydrolase; esterase C4; esterase lipase C8; naphthol-ASBI-P;
    • SPECIAL FEATURES (Morotomi2011);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate;
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Nitrate:
  • not reduced

  • Parasutterella is still a relatively new genus and has been exclusively published in regards to literature on the intestinal microbiome (with the exception of the first two taxonomical papers on the discovery of P. excrementihominis and P. secunda). Both P. excrementihominis and P. secunda were isolated from fecal samples from healthy Japanese individuals and have been found to be part of the intestinal microbiome in the United States.[1][2] In a study that examined the effect of introducing and reversing diet-induced obesity on the gut microbiome and metabolism in mice, Parasutterella was decreased in mice with diet-induced obesity and increased in controls and reversal of the high fat diet with a healthier alternative (normal chow).[5] Other studies have shown increases of Parasutterella with sugar[6] and alcohol consumption.[7] Additional microbiome studies have associated increased abundance of Parasutterella with dysbiosis, or a lack of diversity in the microbial composition typically in the gut.[8][9] (Dysbiosis has been correlated with intestinal and metabolic dysfunction and several diseases, including inflammatory bowel diseases and obesity.)[10] For example, Parasutterella was increased in the submucosa in the ileum of the small intestine in individuals with Crohn's disease[8] and hypertriglyceridemia-related acute necrotizing pancreatitis in rats.[9] More research is needed to further explore the role of Parasutterella species as a part of the healthy gut microbiome and in microbial dysbiosis.

    https://en.wikipedia.org/wiki/Parasutterella

  • Morotomi, M., Nagai, F., & Watanabe, Y. (2011). Parasutterella secunda sp. nov., isolated from human faeces and proposal of Sutterellaceae fam. nov. in the order Burkholderiales. International Journal of Systematic and Evolutionary Microbiology, 61(Pt 3), 637–643.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Proteobacteria Class:  Betaproteobacteria Order:  Burkholderiales Family:  Sutterellaceae Genus:  Parasutterella Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Coccobacillus
    Health:  Unknown
    Source:  human faeces
    DNA G+C(%):  48.2
    		Aesculin:  neg Gelatin:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg Urease:  neg α-Arab:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg ArgDH:  + Chymotrypsin:  neg GluDC:  neg Trypsin:  neg AlanineAA:  neg ArgAA:  neg CystineAA:  neg GluGluAA:  neg GlyAA:  neg HisAA:  neg LeuAA:  neg LeuGlyAA:  neg ProAA:  neg PheAA:  neg PyrogluAA:  neg SerAA:  neg TyrAA:  neg ValAA:  neg AlkalineP:  + AcidP:  neg Esterase(C4):  + EstLip(C8):  + Lipase(C14):  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Indole:  neg

    References

    SPECIFIC REFERENCES FOR PARASUTTERELLA SECUNDA
  • Morotomi2011 - Parasutterella secunda sp. nov., isolated from human faeces and proposal of Sutterellaceae fam. nov. in the order Burkholderiales.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR PARASUTTERELLA SECUNDA
  • Jeong2021 - The effect of taxonomic classification by full-length 16S rRNA sequencing with a synthetic long-read technology
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • ...............................
    • Added: April 08, 2021