Pasteurella dagmatis

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Pasteurella dagmatis is a Gram-negative, non-spore-forming, anaerobic, non-motile, coccus bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 38.9-41.5%. Pasteurella dagmatis is probably a rare gut coloniser. (Mutters1985; Mutters2005Bergey)



  • This organism has been recovered from animal bites causing local and systemic infections. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: zoonotic pathogen). It is an opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Mutters1985); (Mutters2005Bergey);
    Character Response
  • Substrates hydrolysed or digested:
  • urea;
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; galactose; glucose; mannose; maltose; sucrose; trehalose;
  • ⥅
  • Substrates assimilated or utilised:
  • fumarate;
  • Active enzymes:
  • alkaline phosphatase; catalase; oxidase; urease;
    • SPECIAL FEATURES (Mutters1985); (Mutters2005Bergey);
    Character Response
  • ✓
  • Metabolites produced:
  • indole;
  • ✗
  • Haemolysis:
  • absent
  • ✓
  • Nitrate:
  • reduced
    • RESPONSE TO ANTIBIOTICS (Goldstein2017); (Goldstein2012); (Goldstein2000);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; ampicillin-sulbactam; ertapenem; meropenem; penicillin; penicillin G; piperacillin-tazobactam;
  • Cephalosporins:
  • cefazolin;
  • Macrolides:
  • azithromycin; erythromycin;
  • Tetracyclines:
  • doxycycline; minocycline; tetracycline;
  • Quinolines:
  • garenoxacin; levofloxacin; moxifloxacin;
  • Heterocycles:
  • trimethoprim-sulfamethoxazole;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Proteobacteria Class:  Gammaproteobacteria Order:  Pasteurellales Family:  Pasteurellaceae Genus:  Pasteurella Gram stain:  neg O2 Relation.:  anaerobic Spore:  No spore Motility:  Sessile Morphology:  Coccus
    Health:  Unknown
    Source:  animal bites causing local and systemic infections
    DNA G+C(%):  38.9-41.5
    		Aesculin:  neg Urea:  + Gelatin:  w Starch:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Fructose:  + Galactose:  + Glucose:  + Mannose:  + Rhamnose:  neg Sorbose:  neg Xylose:  neg Maltose:  + Sucrose:  + Trehalose:  d(+) Adonitol:  neg Dulcitol:  neg Inositol:  neg Mannitol:  neg Sorbitol:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Fumarate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  + Catalase:  + Urease:  + ArgDH:  neg LysDC:  neg OrnDC:  neg AlkalineP:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Indole:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  S(MIC50): 0.25, MIC90: 0.25, RNG: (0.125–0.25)
    amp-sulb:  S(MIC50): 0.06, MIC90: 0.06, RNG: (0.03–0.06)
    penicillin:  S(MIC50): 0.125, MIC90: 0.2, RNG: (0.06–0.25)
    penicillin_G:  S(MIC50): 0.06, MIC90: 0.125, RNG: (0.02–0.125)
    piper-taz:  S(MIC50): 0.03, MIC90: 0.03, RNG: (0.03–0.03)
    ertapenem:  S(MIC50): 0.015, MIC90: 0.015, RNG: (0.015)
    meropenem:  S(MIC50): 0.03, MIC90: 0.03, RNG: (0.03–0.03)
    cefazolin:  S(MIC50): 0.25, MIC90: 0.5, RNG: (0.125–0.5)
    azithromycin:  S(MIC50): 0.06, MIC90: 0.06, RNG: (0.03–0.125)
    erythromycin:  S(MIC50): 1, MIC90: 2, RNG: (0.25–2)
    garenoxacin:  S(MIC50): 0.008, MIC90: 0.015, RNG: (0.004–0.015)
    levofloxacin:  S(MIC50): ≤0.015, MIC90: ≤0.015, RNG: (≤0.015–0.03)
    moxifloxacin:  S(MIC50): 0.03, MIC90: 0.03, RNG: (0.03–0.03)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(MIC50): 0.125, MIC90: 0.125, RNG: (0.125–0.25)
    minocycline:  S(MIC50): 0.125, MIC90: 0.125, RNG: (0.06–0.125)
    tetracycline:  S(MIC50): 0.25, MIC90: 0.25, RNG: (0.125–0.5)
    SXT:  S(MIC50): 0.06, MIC90: 0.06, RNG: (0.03–0.125)
    clindamycin:  Var(MIC50): 4, MIC90: 8, RNG: (4–8)

    References

    SPECIFIC REFERENCES FOR PASTEURELLA DAGMATIS
  • Mutters1985 - Reclassification of the Genus Pasteurella Trevisan 1887 on the Basis of Deoxyribonucleic Acid Homology, with Proposals for the New Species Pasteurella dagmatis, Pasteurella canis, Pasteurella stomatis, Pasteurella anatis, and Pasteurella langaa
  • Mutters2005Bergey - Bergey's manual of systematic bacteriology. Vol. 2, The Gammaproteobacteria Part B. Family Pasteurellaceae, Genus I. Pasteurella
  • Goldstein2017 - In Vitro Activity of Pexiganan and 10 Comparator Antimicrobials against 234 Isolates, Including 93 Pasteurella Species and 50 Anaerobic Bacterial Isolates Recovered from Animal Bite Wounds.
  • Goldstein2012 - Ceftaroline versus isolates from animal bite wounds: comparative in vitro activities against 243 isolates, including 156 Pasteurella species isolates.
  • Goldstein2000 - Comparative in vitro activities of GAR-936 against aerobic and anaerobic animal and human bite wound pathogens.
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR PASTEURELLA DAGMATIS
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
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    • Added: January 14, 2022