Peptoniphilus indolicus

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Peptoniphilus indolicus is a Gram-positive, non-spore-forming, strictly anaerobic, non-motile, coccus bacterium. It has been detected in at least 3 gut microbiome compilation studies or metastudies. The DNA G+C content is 32-34%. Peptoniphilus indolicus is probably a rare gut coloniser. (Ezaki1983; Ezaki2001; Ezaki2011eBergey)



  • This organism has been recovered from human faeces, animal sources and clinical specimens. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: opportunistic in immunocompromised patients). It is an opportunistic pathogen. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (Ezaki1983); (Ezaki2001); (Ezaki2011eBergey);
    Character Response
  • ⥅
  • Substrates assimilated or utilised:
  • glutamate; serine; threonine; lactate; glutamine;
  • Active enzymes:
  • alkaline phosphatase; Arg arylamidase; coagulase; His arylamidase; Leu arylamidase; Phe arylamidase;
    • SPECIAL FEATURES (Ezaki1983); (Ezaki2001); (Ezaki2011eBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • propionate; butyrate; lactate; ammonia; indole;
  • ✗
  • Metabolites not produced:
  • acetate;
  • ✓
  • NO3➔NO2:
  • reduced
    • RESPONSE TO ANTIBIOTICS (Tyrrell2012);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; ampicillin; ertapenem; imipenem; piperacillin-tazobactam;
  • Cephalosporins:
  • cefmetazole;
  • Heterocycles:
  • metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • daptomycin; linezolid;
  • clindamycin;

  • Benno, Y., Sawada, K., & Mitsuoka, T. (1984). The intestinal microflora of infants: composition of fecal flora in breast-fed and bottle-fed infants. Microbiology and Immunology, 28(9), 975–986.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Tissierellia Order:  Tissierellales Family:  Peptoniphilaceae Genus:  Peptoniphilus Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Coccus
    Health:  Unknown
    Source:  human faeces, animal sources and clinical specimens
    DNA G+C(%):  32-34
    		Aesculin:  neg Gelatin:  neg Starch:  neg Milk:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg Fructose:  neg Galactose:  neg Glucose:  neg Mannose:  neg Rhamnose:  neg Ribose:  neg Maltose:  neg Sucrose:  neg Trehalose:  neg Mannitol:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Glu:  + Ser:  + Thr:  + Lactate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg Coagulase:  + β-Galactosidase:  neg α-Glucosidase:  neg β-Glucuronidase:  neg ArgDH:  neg ArgAA:  + HisAA:  + LeuAA:  + ProAA:  neg PheAA:  + PyrogluAA:  neg AlkalineP:  + Esterase(C4):  neg EstLip(C8):  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  neg Propionate:  + Butyrate:  + Lactate:  + Ammonia:  + Indole:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  S(≤0.06/0.25)
    ampicillin:  S(MIC50): 0.03, MIC90: 0.25, RNG: (0.03–>8)
    piper-taz:  S(MIC50): 0.03, MIC90: 0.5, RNG: (0.03–16)
    ertapenem:  S(0.06/0.25)
    imipenem:  S(MIC50): 0.03, MIC90: 0.06, RNG: (0.03–2)
    cefmetazole:  S(0.06)
    linezolid:  S(MIC50): 0.5, MIC90: 1, RNG: (0.25–2)
    levofloxacin:  Var(MIC50): 4), MIC90: Var(4
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    vancomycin:  S(MIC50): 0.25, MIC90: 0.5, RNG: (0.06–1)
    metronidazole:  S(MIC50): 0.25, MIC90: 1, RNG: (0.03–2)
    clindamycin:  R(32)
    daptomycin:  S(MIC50): 0.125, MIC90: 0.5, RNG: (0.03–1)

    References

    SPECIFIC REFERENCES FOR PEPTONIPHILUS INDOLICUS
  • Ezaki1983 - Transfer of Peptococcus indolicus, Peptococcus asaccharolyticus, Peptococcus prevotii, and Peptococcus magnus to the Genus Peptostreptococcus and Proposal of Peptostreptococcus tetradius sp. nov.
  • Ezaki2001 - Proposal of the genera Anaerococcus gen. nov., Peptoniphilus gen. nov. and Gallicola gen. nov. for members of the genus Peptostreptococcus.
  • Ezaki2011eBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Clostridiales, Family XI. Incertae Sedis, Genus VI. Peptoniphilus
  • Yu2015 - Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer
  • Tyrrell2012 - In vitro activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic, against 377 strains of anaerobic bacteria and 34 strains of Corynebacterium species.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR PEPTONIPHILUS INDOLICUS
  • Benno1984 - The intestinal microflora of infants: composition of fecal flora in breast-fed and bottle-fed infants.
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • ...............................
    • GENERAL REFERENCES FOR PEPTONIPHILUS INDOLICUS
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: April 08, 2021