Phocaeicola coprophilus

(aka Bacteroides coprophilus)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Phocaeicola coprophilus, (aka Bacteroides coprophilus), is a Gram-negative, non-spore-forming, anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 21 gut microbiome compilation studies or metastudies. The DNA G+C content is 44.2-45.2%. Phocaeicola coprophilus is often a widespread coloniser of gut. (Hayashi2007)



  • This organism has been recovered from human faeces (CCUG). The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal.
    • QUIRKS
  • In 87% of Europeans (unseenbio.com).
    • GENERAL CHARACTERISTICS (Hayashi2007);
    Character Response
  • 💧
  • Bile tolerance:
  • Grows in the presence of bile
  • 🌡
  • Temperature tolerance:
  • grows at 37℃;
  • H+
  • Acid from carbohydrates usually produced:
  • glucose; mannose; lactose; raffinose; sucrose;
  • Active enzymes:
  • Ala arylamidase; alkaline phosphatase; Arg arylamidase; N-Ac β-glucosaminidase; fucosidase; α-galactosidase; β-galactosidase; α-glucosidase; β-glucosidase; His arylamidase; Leu arylamidase; Leu-Gly arylamidase;
    • SPECIAL FEATURES (Hayashi2007);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; propionate (minor); succinate; isovalerate (minor); pyruvate (minor);
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Nitrate:
  • not reduced

  • Hayashi, H., Shibata, K., Bakir, M. A., Sakamoto, M., Tomita, S., & Benno, Y. (2007). Bacteroides coprophilus sp. nov., isolated from human faeces. International Journal of Systematic and Evolutionary Microbiology, 57(Pt 6), 1323–1326.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Bacteroidetes Class:  Bacteroidia Order:  Bacteroidales Family:  Bacteroidaceae Genus:  Phocaeicola Alt. name:  Bacteroides coprophilus Gram stain:  neg O2 Relation.:  anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces (CCUG)
    DNA G+C(%):  44.2-45.2
    Mid T(℃):  37(+)
    Bile reaction(%):  +
    		Aesculin:  neg Urea:  neg Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    L-Arabinose:  neg Glucose:  + Mannose:  + Rhamnose:  neg Xylose:  neg Cellubiose:  w Lactose:  + Sucrose:  + Salicin:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Urease:  neg α-Arab:  neg Ac-β-glcamnd:  + α-Fucosidase:  + α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  + β-Glucuronidase:  neg ArgDH:  neg GluDC:  neg AlanineAA:  + ArgAA:  + GluGluAA:  w GlyAA:  w HisAA:  + LeuAA:  + LeuGlyAA:  + ProAA:  neg PheAA:  w PyrogluAA:  neg SerAA:  w TyrAA:  w AlkalineP:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    Acetate, Succinate

    		Acetate:  + Propionate:  minor(+) Succinate:  + Isovalerate:  minor(+) Pyruvate:  minor(+) Indole:  neg

    References

    SPECIFIC REFERENCES FOR PHOCAEICOLA COPROPHILUS
  • Breban2017 - Faecal microbiota study reveals specific dysbiosis in spondyloarthritis
  • Li2012 - Molecular-phylogenetic characterization of the microbiota in ulcerated and non-ulcerated regions in the patients with Crohn's disease
  • Miyake2015 - Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters
  • Wang2019b - Alterations in the human gut microbiome associated with Helicobacter pylori infection
  • Hayashi2007 - Bacteroides coprophilus sp. nov., isolated from human faeces.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR PHOCAEICOLA COPROPHILUS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Li2019b - Disordered intestinal microbes are associated with the activity of Systemic Lupus Erythematosus
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • Nielsen2014 - MetaHIT Consortium. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.
  • PerezBrocal2015 - Metagenomic Analysis of Crohn's Disease Patients Identifies Changes in the Virome and Microbiome Related to Disease Status and Therapy, and Detects Potential Interactions and Biomarkers
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Rothschild2018 - Environment dominates over host genetics in shaping human gut microbiota.
  • Tyakht2013 - Human gut microbiota community structures in urban and rural populations in Russia.
  • Urban2020 - Altered Fecal Microbiome Years after Traumatic Brain Injury
  • Wang2020a - Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • Zupancic2012 - Analysis of the Gut Microbiota in the Old Order Amish and Its Relation to the Metabolic Syndrome.
  • ...............................
    • GENERAL REFERENCES FOR PHOCAEICOLA COPROPHILUS
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
    • Added: April 08, 2021