Phocaeicola sartorii

(aka Bacteroides sartorii)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Phocaeicola sartorii, (aka Bacteroides sartorii), is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 4 gut microbiome compilation studies or metastudies. The DNA G+C content is 41.5%. Phocaeicola sartorii is a common gut coloniser. (Kitahara2011; Sakamoto2012; Clavel2010)



  • This organism has been recovered from human faeces and mice caeca. Pathogenicity status unknown, or very unlikely to be pathogenic. A possible gut commensal.
    • QUIRKS
  • In 99% of Europeans (unseenbio.com).
    • GENERAL CHARACTERISTICS (Kitahara2011); (Sakamoto2012); (Clavel2010);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin;
  • 💧
  • Bile tolerance:
  • Resistant to 0.5% bile
  • pH
  • Acidity tolerance:
  • Grows optimally at pH 6-9.
  • 🌡
  • Temperature tolerance:
  • grows at 25℃; grows at 40℃; Grows optimally at 37℃.
  • H+
  • Acid from carbohydrates usually produced:
  • L-arabinose; glucose; mannose; rhamnose; xylose; cellubiose; lactose; maltose; melibiose; raffinose;
  • ±
  • Strain-dependent acid from carbs:
  • sucrose;
  • Active enzymes:
  • Ala arylamidase; alkaline phosphatase; arabinosidase; N-Ac β-glucosaminidase; fucosidase; α-galactosidase; β-galactosidase; α-glucosidase; β-glucosidase; Glu-Glu arylamidase; Gly arylamidase; Leu-Gly arylamidase;
  • ±
  • Strain-dependent active enzymes:
  • Arg arylamidase; Leu arylamidase;
    • SPECIAL FEATURES (Kitahara2011); (Sakamoto2012);
    Character Response
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Clavel2010);
    Class Active Resistant
  • Cephalosporins:
  • cefotaxime;
  • Macrolides:
  • clarithromycin; erythromycin;
  • Tetracyclines:
  • tetracycline;
  • Aminoglycosides:
  • tobramycin;
  • Heterocycles:
  • metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Bacteroidetes Class:  Bacteroidia Order:  Bacteroidales Family:  Bacteroidaceae Genus:  Phocaeicola Alt. name:  Bacteroides sartorii Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces and mice caeca
    DNA G+C(%):  41.5
    Opt. T:  37℃
    Lower T(℃):  25(+)
    Mid T(℃):  40(+)
    Opt. pH:  6-9
    Bile reaction(%):  0.5(+)
    		Aesculin:  + Urea:  neg Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    L-Arabinose:  + Fructose:  neg Glucose:  + Mannose:  + Rhamnose:  + Xylose:  + Cellubiose:  + Lactose:  + Maltose:  + Melezitose:  neg Melibiose:  + Sucrose:  d Trehalose:  neg Glycerol:  neg Mannitol:  neg Sorbitol:  neg Salicin:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Fructose:  neg Galactose:  neg Glucose:  neg Mannose:  neg Raffinose:  neg Sucrose:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg α-Arab:  + Ac-β-glcamnd:  + α-Fucosidase:  + α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  + β-Glucuronidase:  neg ArgDH:  neg GluDC:  neg AlanineAA:  + ArgAA:  d GluGluAA:  + GlyAA:  + HisAA:  neg LeuAA:  d LeuGlyAA:  + ProAA:  neg PheAA:  neg PyrogluAA:  neg SerAA:  neg TyrAA:  neg AlkalineP:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    oxacillin:  Var(MIC50): 8.5), MIC90: Var(8.5
    cefotaxime:  R(>32)
    tobramycin:  R(>256)
    erythromycin:  S(0.15)
    clarithromycin:  S(0.006)
    ciprofloxacin:  Var(MIC50): 3), MIC90: Var(3
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  S(0.089)
    vancomycin:  S(4.7)
    metronidazole:  S(0.11)
    clindamycin:  S(<0.016)

    References

    SPECIFIC REFERENCES FOR PHOCAEICOLA SARTORII
  • Kishikawa2020 - Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population
  • Kitahara2011 - Bacteroides chinchillae sp. nov. and Bacteroides rodentium sp. nov., isolated from chinchilla (Chinchilla lanigera) faeces.
  • Sakamoto2012 - Bacteroides sartorii is an earlier heterotypic synonym of Bacteroides chinchillae and has priority.
  • Clavel2010 - Isolation of bacteria from mouse caecal samples and description of Bacteroides sartorii sp. nov.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR PHOCAEICOLA SARTORII
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • Urban2020 - Altered Fecal Microbiome Years after Traumatic Brain Injury
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • ...............................
    • GENERAL REFERENCES FOR PHOCAEICOLA SARTORII
  • GarciaLopez2019 - Analysis of 1,000 Type-Strain Genomes Improves Taxonomic Classification of Bacteroidetes.
    • Added: December 15, 2021