Prevotella shahii

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Prevotella shahii is a Gram-negative, non-spore-forming, anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 2 gut microbiome compilation studies or metastudies. The DNA G+C content is 44-45%. Prevotella shahii is probably a rare gut coloniser. (Sakamoto2004; Shah2010Bergeys)



  • This organism has been recovered from oral cavity and human faeces. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Sakamoto2004); (Shah2010Bergeys);
    Character Response
  • Substrates hydrolysed or digested:
  • gelatin;
  • 💧
  • Bile tolerance:
  • Doesn't tolerate 20% bile
  • H+
  • Acid from carbohydrates usually produced:
  • glucose; mannose; lactose; maltose; raffinose; sucrose;
  • Active enzymes:
  • Ala arylamidase; acid phosphatase; N-Ac β-glucosaminidase; naphthol-ASBI-P;
    • SPECIAL FEATURES (Sakamoto2004); (Shah2010Bergeys);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; succinate;
  • ✗
  • Metabolites not produced:
  • indole;
  • Pigments:
  • light brown

  • Prevotella species at mucosal sites to localized and systemic disease, including periodontitis, bacterial vaginosis, rheumatoid arthritis, metabolic disorders and low_grade systemic inflammation. Intriguingly, Prevotella abundance is reduced within the lung microbiota of patients with asthma and chronic obstructive pulmonary disease. Increased Prevotella abundance is associated with augmented T helper type 17 (Th17) _mediated mucosal inflammation, which is in line with the marked capacity of Prevotella in driving Th17 immune responses in vitro. Studies indicate that Prevotella predominantly activate Toll_like receptor 2, leading to production of Th17_polarizing cytokines by antigen_presenting cells, including interleukin_23 (IL_23) and IL_1. Furthermore, Prevotella stimulate epithelial cells to produce IL_8, IL_6 and CCL20, which can promote mucosal Th17 immune responses and neutrophil recruitment. Prevotella_mediated mucosal inflammation leads to systemic dissemination of inflammatory mediators, bacteria and bacterial products, which in turn may affect systemic disease outcomes. [PMID: 28542929]

  • GutFeeling KnowledgeBase COMMENTS [Website]

    Prevotella species are anaerobic Gram_negative bacteria of the Bacteroidetes phylum, which also includes the clinically important genera Bacteroides and Porphyromonas. Prevotella strains are classically considered commensal bacteria due to their extensive presence in the healthy human body and their rare involvement in infections. Only a few strains have been reported to give rise to opportunistic endogenous infections, including chronic infections, abscesses and anaerobic pneumonia. [PMID: 28542929]

  • Wang, M., Ahrné, S., Jeppsson, B., & Molin, G. (2005). Comparison of bacterial diversity along the human intestinal tract by direct cloning and sequencing of 16S rRNA genes. FEMS Microbiology Ecology, 54(2), 219–231.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Bacteroidetes Class:  Bacteroidia Order:  Bacteroidales Family:  Prevotellaceae Genus:  Prevotella Gram stain:  neg O2 Relation.:  anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod Pigment:  light brown
    Health:  Unknown
    Source:  oral cavity and human faeces
    DNA G+C(%):  44-45
    Bile reaction(%):  20(neg)
    		Aesculin:  neg Gelatin:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg D-Arabinose:  neg Glucose:  + Mannose:  + Rhamnose:  neg Xylose:  neg Cellubiose:  neg Lactose:  + Maltose:  + Melezitose:  neg Sucrose:  + Trehalose:  neg Glycerol:  neg Mannitol:  neg Sorbitol:  neg Salicin:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg G6PDH6PGDH:  neg α-Arab:  neg Ac-β-glcamnd:  + α-Fucosidase:  w α-Galactosidase:  w β-Galactosidase:  w α-Glucosidase:  w β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg Chymotrypsin:  neg Trypsin:  neg AlanineAA:  + ArgAA:  neg CystineAA:  neg GlyAA:  neg HisAA:  neg LeuAA:  neg ProAA:  neg PheAA:  neg PyrogluAA:  neg TyrAA:  neg ValAA:  neg AlkalineP:  w AcidP:  + Esterase(C4):  neg EstLip(C8):  neg Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Succinate:  + Indole:  neg Pigment:  light brown

    References

    SPECIFIC REFERENCES FOR PREVOTELLA SHAHII
  • Sakamoto2004 - Prevotella shahii sp. nov. and Prevotella salivae sp. nov., isolated from the human oral cavity.
  • Shah2010Bergeys - Bergey's manual of systematic bacteriology. Vol. 4, The Bacteroidetes. Family Prevotellaceae, Genus I. Prevotella
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR PREVOTELLA SHAHII
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
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    • Added: April 08, 2021