Propionimicrobium lymphophilum

(aka Propionibacterium lymphophilum)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Propionimicrobium lymphophilum, (aka Propionibacterium lymphophilum), is a Gram-negative, non-spore-forming, anaerobic, non-motile, pleiomorph rod-shaped bacterium. It has been detected in at least 2 gut microbiome compilation studies or metastudies. The DNA G+C content is 53-54%. Propionimicrobium lymphophilum is probably a rare gut coloniser. (Stackebrandt2002a; Torrey1916)



  • This organism has been recovered from lymph nodes and is associated with Hodgkin's disease. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. Is a known human pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Stackebrandt2002a); (Torrey1916);
    Character Response
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; glucose; ribose; starch; maltose; adonitol; erythritol; inositol;
  • ±
  • Strain-dependent active enzymes:
  • catalase;
    • SPECIAL FEATURES (Stackebrandt2002a);
    Character Response
  • ✓
  • Metabolites produced:
  • formate (minor); acetate; propionate; succinate; isovalerate;
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • VP test:
  • not active
  • ✗
  • Haemolysis:
  • absent
  • ±
  • Nitrate:
  • strain dependent
    • RESPONSE TO ANTIBIOTICS (Goldstein2000);
    Class Active Resistant
  • Penicillins:
  • penicillin G;
  • Macrolides:
  • azithromycin; erythromycin;
  • Tetracyclines:
  • doxycycline; minocycline; tetracycline;
  • Quinolines:
  • levofloxacin; moxifloxacin;
  • Vancomycins:
  • vancomycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Propionibacteriales Family:  Propionibacteriaceae Genus:  Propionimicrobium Alt. name:  Propionibacterium lymphophilum Gram stain:  neg O2 Relation.:  anaerobic Spore:  No spore Motility:  Sessile Morphology:  Pleiomorph rod
    Health:  Unknown
    Source:  lymph nodes and is associated with Hodgkin's disease
    DNA G+C(%):  53-54
    		Aesculin:  neg Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg Fructose:  + Galactose:  neg Glucose:  + Mannose:  neg Rhamnose:  neg Ribose:  + Sorbose:  neg Cellubiose:  neg Lactose:  neg Maltose:  + Melezitose:  neg Amygdalin:  neg Aesculin:  neg Inulin:  neg Starch:  + Adonitol:  + Dulcitol:  neg Erythritol:  + Glycerol:  neg Inositol:  + Mannitol:  neg Sorbitol:  neg Salicin:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  d
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Formate:  minor(+) Acetate:  + Propionate:  + Succinate:  + Isovalerate:  + Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    penicillin_G:  S(MIC50): 0.03, MIC90: 0.25, RNG: (≤0.015–0.5)
    azithromycin:  S(MIC50): 0.06, MIC90: 0.25, RNG: (0.03–>32)
    erythromycin:  S(MIC50): 0.06, MIC90: 0.25, RNG: (0.03–.128)
    levofloxacin:  S(MIC50): 0.25, MIC90: 0.5, RNG: (0.125–1)
    moxifloxacin:  S(MIC50): 0.25, MIC90: 0.5, RNG: (0.06–1)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(MIC50): 0.25, MIC90: 0.5, RNG: (0.06–1)
    minocycline:  S(MIC50): 0.125, MIC90: 0.25, RNG: (0.06–1)
    tetracycline:  S(MIC50): 1, MIC90: 2, RNG: (0.5–4)
    vancomycin:  S(MIC50): 0.5, MIC90: 1, RNG: (0.25–1)

    References

    SPECIFIC REFERENCES FOR PROPIONIMICROBIUM LYMPHOPHILUM
  • Nouioui2018 - Genome-Based Taxonomic Classification of the Phylum Actinobacteria.
  • Stackebrandt2002a - Propionimicrobium gen. nov., a new genus to accommodate Propionibacterium lymphophilum (Torrey 1916) Johnson and Cummins 1972, 1057AL as Propionimicrobium lymphophilum comb. nov.
  • Eberson1918 - Bacteriologic Study of the Diphtheroid Organisms with Special Reference to Hodgkin's Disease.
  • Torrey1916 - Bacteria associated with certain types of abnormal Lymph Glands.
  • Johnson1972 - Cell wall composition and deoxyribonucleic acid similarities among the anaerobic coryneforms, classical propionibacteria, and strains of Arachnia propionica.
  • Goldstein2000 - Comparative in vitro activities of GAR-936 against aerobic and anaerobic animal and human bite wound pathogens.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR PROPIONIMICROBIUM LYMPHOPHILUM
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
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    • Added: January 14, 2022