Pseudoglutamicibacter cumminsii

(aka Arthrobacter cumminsii)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Pseudoglutamicibacter cumminsii, (aka Arthrobacter cumminsii), is a Gram-positive, non-spore-forming, strictly aerobic, non-motile, coryneform bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 60-62%. Pseudoglutamicibacter cumminsii is likely to be transient and not a long-term gut coloniser. (Busse2016; Funke1996)



  • This organism has been recovered from clinical specimens (wounds, UTI, amniotic fluid, blood, infections). The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. It is an opportunistic pathogen. Likely to be transient and not a long-term gut commensal.
    • QUIRKS
  • Strict aerobe, so unlikely to be a gut coloniser.
    • GENERAL CHARACTERISTICS (Busse2016); (Funke1996);
    Character Response
  • Substrates hydrolysed or digested:
  • DNA; gelatin;
  • ±
  • Strain-dependent hydrolysis or digestion:
  • urea;
  • 🌡
  • Temperature tolerance:
  • grows at 37℃;
  • H+
  • Acid from carbohydrates usually produced:
  • ribose;
  • ±
  • Strain-dependent acid from carbs:
  • glucose;
  • Active enzymes:
  • acid phosphatase; catalase; esterase C4; esterase lipase C8; Leu arylamidase; phosphoamidase;
  • ±
  • Strain-dependent active enzymes:
  • alkaline phosphatase; cystine arylamidase; pyrrolidine arylamidase; urease;
    • SPECIAL FEATURES (Busse2016);
    Character Response
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Funke1996);
    Class Active Resistant
  • Penicillins:
  • amoxicillin; amoxicillin-clavulanic acid; imipenem; oxacillin; penicillin;
  • aztreonam;
  • Cephalosporins:
  • cefaclor; ceftazidime;
  • Macrolides:
  • azithromycin; clarithromycin; erythromycin;
  • Tetracyclines:
  • doxycycline;
  • Quinolines:
  • norfloxacin; ofloxacin;
  • Aminoglycosides:
  • amikacin; gentamicin; netilmycin; tobramycin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • fusidic-acid;
  • fosfomycin;
  • Vancomycins:
  • vancomycin; teicoplanin;
  • Miscellaneous antibiotics:
  • clindamycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Micrococcales Family:  Micrococcaceae Genus:  Pseudoglutamicibacter Alt. name:  Arthrobacter cumminsii Gram stain:  + O2 Relation.:  strictly aerobic Spore:  No spore Motility:  Sessile Morphology:  Coryneform
    Health:  Unknown
    Source:  clinical specimens (wounds, UTI, amniotic fluid, blood, infections)
    DNA G+C(%):  60-62
    Mid T(℃):  37(+)
    		Aesculin:  neg Urea:  d Gelatin:  + DNA:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Glucose:  d Ribose:  + Xylose:  neg Lactose:  neg Maltose:  neg Sucrose:  neg Glycogen:  neg Mannitol:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  + Urease:  d Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg Chymotrypsin:  neg CystineAA:  d LeuAA:  + PyrrolidAA:  d AlkalineP:  d AcidP:  + Esterase(C4):  + EstLip(C8):  + Phosphoamidase:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  S(MIC50): ≤0.06, MIC90: 1, RNG: (≤0.06–2)
    Augmentin:  S(MIC50): ≤0.06, MIC90: ≤0.06, RNG: (≤0.06–0.25)
    aztreonam:  R(MIC50): 16, MIC90: >64, RNG: (1–>64)
    oxacillin:  S(MIC50): 0.125, MIC90: 2, RNG: (≤0.03–4)
    penicillin:  S(MIC50): ≤0.01, MIC90: 0.5, RNG: (≤0.01–0.5)
    piperacillin:  Var(MIC50): ≤0.125, MIC90: 4, RNG: (≤0.125–4)
    imipenem:  S(MIC50): 0.06, MIC90: 0.125, RNG: (≤0.03–0.125)
    cefaclor:  S(MIC50): ≤0.06, MIC90: 0.125, RNG: (≤0.06–0.5)
    ceftazidime:  S(MIC50): 1, MIC90: 2, RNG: (0.5–8)
    amikacin:  R(MIC50): 16, MIC90: 64, RNG: (4–64)
    gentamicin:  R(MIC50): 8, MIC90: 16, RNG: (2–>128)
    netilmycin:  R(MIC50): 64, MIC90: >128, RNG: (4–>128)
    tobramycin:  R(MIC50): 64, MIC90: >128, RNG: (16–>128)
    azithromycin:  S(MIC50): 0.125, MIC90: 0.5, RNG: (0.06–4)
    erythromycin:  S(MIC50): ≤0.03, MIC90: 0.125, RNG: (≤0.03–1)
    clarithromycin:  S(MIC50): ≤0.03, MIC90: 0.06, RNG: (≤0.03–0.5)
    ciprofloxacin:  Var(MIC50): 2, MIC90: 16, RNG: (0.5–>32)
    norfloxacin:  R(MIC50): 32, MIC90: >64, RNG: (8–>64)
    ofloxacin:  R(MIC50): 4, MIC90: 32, RNG: (1–32)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(MIC50): 0.5, MIC90: 1, RNG: (0.25–8)
    tetracycline:  Var(MIC50): 1, MIC90: 16, RNG: (1–64)
    teicoplanin:  S(MIC50): 0.5, MIC90: 0.5, RNG: (0.125–0.5)
    vancomycin:  S(MIC50): 1, MIC90: 1, RNG: (0.5–1)
    rifampicin:  S(MIC50): ≤0.01, MIC90: ≤0.01, RNG: (≤0.01)
    chloramphenicol:  Var(MIC50): 2, MIC90: 32, RNG: (1–64)
    fosfomycin:  R(MIC50): 32, MIC90: >256, RNG: (16–>256)
    clindamycin:  S(MIC50): 0.125, MIC90: 1, RNG: (0.03–1)
    fusidic-acid:  S(MIC50): 0.25, MIC90: 0.25, RNG: (0.125–0.5)

    References

    SPECIFIC REFERENCES FOR PSEUDOGLUTAMICIBACTER CUMMINSII
  • Busse2016 - Review of the taxonomy of the genus Arthrobacter, emendation of the genus Arthrobacter sensu lato, proposal to reclassify selected species of the genus Arthrobacter in the novel genera Glutamicibacter gen. nov., Paeniglutamicibacter gen. nov., Pseudoglutamicibacter gen. nov., Paenarthrobacter gen. nov. and Pseudarthrobacter gen. nov., and emended description of Arthrobacter roseus.
  • Funke1996 - Isolation of Arthrobacter spp. from clinical specimens and description of Arthrobacter cumminsii sp. nov. and Arthrobacter woluwensis sp. nov.
  • Funke1998a - Characteristics of Arthrobacter cumminsii, the most frequently encountered Arthrobacter species in human clinical specimens.
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR PSEUDOGLUTAMICIBACTER CUMMINSII
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
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    • Added: January 14, 2022