Rhodococcus hoagii

(aka Rhodococcus equi)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Rhodococcus hoagii, (aka Rhodococcus equi), is a Gram-positive, non-spore-forming, aerobic, non-motile, bacterium. It has been detected in at least 4 gut microbiome compilation studies or metastudies. Rhodococcus hoagii is probably a rare gut coloniser.



  • This organism has been recovered from human faeces. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: human and animal pathogen). It is an opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Kaempfer2014a);
    Character Response
  • ⥅
  • Substrates assimilated or utilised:
  • 3-hydroxybenzoate; lactate;
  • ±
  • Strain-dependent substrate utilisation:
  • mannose; sucrose;
    • RESPONSE TO ANTIBIOTICS
    Class Active Resistant
  • Macrolides:
  • azithromycin; clarithromycin; erythromycin; roxithromycin; telithromycin;
  • quinupristin-dalfopristin;
  • Tetracyclines:
  • doxycycline;
  • Quinolines:
  • levofloxacin; sarafloxacin;
  • Polypep/ketides:
  • rifapentine;
  • Vancomycins:
  • vancomycin; dalbavancin; teicoplanin;
  • Miscellaneous antibiotics:
  • linezolid; telithromycin;
  • lincomycin;

  • Lagier, J.-C., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., Trape, J.-F., Koonin, E. V., La Scola, B., & Raoult, D. (2012). Microbial culturomics: paradigm shift in the human gut microbiome study. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(12), 1185–1193.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Mycobacteriales Family:  Nocardiaceae Genus:  Rhodococcus Alt. name:  Rhodococcus equi Gram stain:  + O2 Relation.:  aerobic Spore:  No spore Motility:  Sessile
    Health:  Unknown
    Source:  human faeces
    		Aesculin:  neg Urea:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    L-Arabinose:  neg Galactose:  neg Mannose:  d Rhamnose:  neg Ribose:  neg Xylose:  neg Cellubiose:  neg Lactose:  neg Sucrose:  d Trehalose:  neg D-Arabitol:  neg Inositol:  neg Mannitol:  neg Sorbitol:  neg 3-Hydroxybenzoate:  + Lactate:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    penicillin:  Var(MIC50): 4, MIC90: 8, RNG: (≤0.015-8)
    azithromycin:  S(MIC50): 1, MIC90: 1, RNG: (0.03-2)
    erythromycin:  S(MIC50): 0.5, MIC90: 0.5, RNG: (≤0.015-0.5)
    clarithromycin:  S(MIC50): 0.06, MIC90: 0.06, RNG: (≤0.015-0.12)
    pristinamycin:  Var(MIC50): 4, MIC90: 4, RNG: (0.03-4)
    quin-dalf:  R(MIC50): 8, MIC90: 8, RNG: (0.12-8)
    roxithromycin:  S(MIC50): 0.25, MIC90: 0.25, RNG: (≤0.015-0.25)
    telithromycin:  S(MIC50): 0.25, MIC90: 0.25, RNG: (≤0.015-0.25)
    josamycin:  Var(MIC50): 2, MIC90: 4, RNG: (0.03-8)
    linezolid:  S(MIC50): 2, MIC90: 2, RNG: (0.5-2)
    levofloxacin:  S(MIC50): 0.5, MIC90: 1, RNG: (0.25-1)
    sarafloxacin:  S(MIC50): 1, MIC90: 2, RNG: (≤0.06-8)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(MIC50): 2, MIC90: 2, RNG: (0.12-2)
    tetracycline:  Var(MIC50): 4, MIC90: 8, RNG: (0.25-8)
    dalbavancin:  S(MIC50): 1, MIC90: 1, RNG: (≤0.03-4)
    teicoplanin:  S(MIC50): 0.25, MIC90: 0.25, RNG: (0.12-0.25)
    vancomycin:  S(MIC50): 0.25, MIC90: 0.5, RNG: (0.12-0.5)
    rifapentine:  S(MIC50): 0.25, MIC90: 0.25, RNG: (≤0.015-0.5)
    lincomycin:  R(MIC50): 16, MIC90: 16, RNG: (0.25-16)

    References

    SPECIFIC REFERENCES FOR RHODOCOCCUS HOAGII
  • Kaempfer2014a - Rhodococcus defluvii sp. nov., isolated from wastewater of a bioreactor and formal proposal to reclassify [Corynebacterium hoagii] and Rhodococcus equi as Rhodococcus hoagii comb. nov.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR RHODOCOCCUS HOAGII
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Taylor1985 - Nine-year microflora study of an isolator-maintained immunodeficient child.
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
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    • Added: April 08, 2021